ECSP972244A - BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS - Google Patents

BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS

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Publication number
ECSP972244A
ECSP972244A ECSP972244A ECSP972244A EC SP972244 A ECSP972244 A EC SP972244A EC SP972244 A ECSP972244 A EC SP972244A EC SP972244 A ECSP972244 A EC SP972244A
Authority
EC
Ecuador
Prior art keywords
disease
inhibitors
derivatives
treatment
gelatinase
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Claude Forsey
Bruce David Roth
Andrew David White
Gerald P Chielke
Walker Lary Craswell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP972244 priority Critical patent/ECSP972244A/en
Publication of ECSP972244A publication Critical patent/ECSP972244A/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen los compuestos de ácido bifenil butírico y sus derivados así como también los métodos para su preparación y sus composiciones farmacéuticas, que son útiles como inhibidores de las metaloproteinasas de matriz, particularmente la gelatinasa A (gelatinasa 72Kd) y estromelisina-1 para el tratamiento de las esclerosis múltiple, ruptura de placa ateroescclerótica, aneurisma aórtico, paro cardiaco, restenosis, enfermedad periodontal, ulceración corneana, tratamiento de las quemaduras, úlceras decubitables, curación de heridas, cáncer, inflamación dolo, artritis y otros transtornos autoinmunes o inllamatorios dependientes de la invación del tejido por leucocitos u otras células migratorias activadas, tratornos neurodegenerativos crónicos incluyendo el paro cardiaco, trauma cerebral, daño en la médula espinal, enfermedad de Alzheimer, esclerosis lateral amiotrófica, angiopatia amiloide cerebral, SIDA, enfermedad de Parkinson, enfermedad de Huntington, enfermedades de Prion, miastenia gravis, y distrofia muscular de Duchenne.Biphenyl butyric acid compounds and their derivatives are described as well as methods for their preparation and their pharmaceutical compositions, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (gelatinase 72Kd) and stromelysin-1 for treatment. of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, cardiac arrest, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubitable ulcers, wound healing, cancer, painful inflammation, arthritis and other autoimmune or inflammatory disorders dependent on tissue invasion by leukocytes or other activated migratory cells, chronic neurodegenerative disorders including cardiac arrest, brain trauma, spinal cord damage, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease sick ades de Prion, myasthenia gravis, and Duchenne muscular dystrophy.

ECSP972244 1997-09-03 1997-09-03 BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS ECSP972244A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP972244 ECSP972244A (en) 1997-09-03 1997-09-03 BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP972244 ECSP972244A (en) 1997-09-03 1997-09-03 BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS

Publications (1)

Publication Number Publication Date
ECSP972244A true ECSP972244A (en) 1998-12-14

Family

ID=42043075

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP972244 ECSP972244A (en) 1997-09-03 1997-09-03 BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS

Country Status (1)

Country Link
EC (1) ECSP972244A (en)

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