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Publication of UY24693A1publicationCriticalpatent/UY24693A1/en
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
Compuestos de ácido bifenil butírico y sus derivados así como los métodos para su preparación y sus composiciones farmacéuticas. Que son útiles como inhibidores de las metaloproteinasas de matriz, particularmente la gelatinasa a y estromelisina-1 y para el tratamiento de las esclerosis múltiple, ruptura de placa arteroesclerótica, aneurisma aórtico, paro cardíaco, restenosis, enfermedad periodontal, ulceración corneana, tratamiento de las quemaduras, úlceras decubitales, curación de heridas, cáncer, inflamación, dolor, artitris y otros trastornos autoinmunes o inflamatorios dependientes de la invasión del tejido por leucocitos u otras células migratorias activadas.Biphenyl butyric acid compounds and their derivatives as well as the methods for their preparation and their pharmaceutical compositions. Which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase a and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, cardiac arrest, restenosis, periodontal disease, corneal ulceration, treatment of burns. , decubital ulcers, wound healing, cancer, inflammation, pain, arthritis and other autoimmune or inflammatory disorders dependent on tissue invasion by leukocytes or other activated migratory cells.
UY24693A1996-09-041997-09-03
BUTHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METALOPROTEINASE INHIBITORS
UY24693A1
(en)
COMPOUND DERIVED FROM DIFENIL BUTIRICO ACID, ITS USE FOR TREATMENT METHODS BASED ON INHIBITING MATRIX METALOPROTEINASE, ITS USE FOR THE MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS AND ITS PREPARATION METHOD
METALOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES AND USEFUL METHODS AND INTERMEDIATES FOR THEIR PREPARATION.
HEAVY METAL SALTS OF SEMYESTERS OF SUCCINIC ACID WITH HYALURONIC ACID, OR WITH ESTERS OF HYALURONIC ACID. A PROCESS FOR RELATED PHARMACEUTICAL PREPARATION AND COMPOSITIONS.