ECSP972226A - NON-ULCEROGENIC ANTI-INFLAMMATORY ANALGESIC DERIVATIVE OF CLONIXINE - Google Patents
NON-ULCEROGENIC ANTI-INFLAMMATORY ANALGESIC DERIVATIVE OF CLONIXINEInfo
- Publication number
- ECSP972226A ECSP972226A ECSP972226A ECSP972226A EC SP972226 A ECSP972226 A EC SP972226A EC SP972226 A ECSP972226 A EC SP972226A EC SP972226 A ECSP972226 A EC SP972226A
- Authority
- EC
- Ecuador
- Prior art keywords
- clonixate
- clonixine
- derivative
- nitroxybutyl
- chlorobutyl
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
El derivado de clonixina de fórmula (I) o clonixato de 4-nitroxibutilo, es un nuevo producto analgésico antiinflamatorio no esteroideo, que tiene un equilibrio extraordinariamente bueno entre una alta actividad analgésica/antiinflamatoria y bajos efectos adversos ulcerogénicos, principalmente como una consecuencia de una sorprendente alta actividad antitnflamatoria (dos veces la del ácido cloníxico). El compuesto (I) se prepara haciendo reaccionar el clonixato de 4-clorobutilo con nitrato de plata en acetonitrilo. El clonixato de 4-clorobutilo se prepara por reacción de un clonixato alcalino con 1-bromo-4-clorobunato en acetonitrilo. El clonixato de 4-nitroxibutilo (I) es especialmente útil como principio activo para el tratamiento del dolor y/o inflamación en mamíferos.(gráfico).The clonixin derivative of formula (I) or 4-nitroxybutyl clonixate, is a new non-steroidal anti-inflammatory pain reliever product, which has an extraordinarily good balance between high analgesic / anti-inflammatory activity and low ulcerogenic side effects, mainly as a consequence of a surprisingly high anti-inflammatory activity (twice that of clonoxic acid). Compound (I) is prepared by reacting 4-chlorobutyl clonixate with silver nitrate in acetonitrile. The 4-chlorobutyl clonixate is prepared by reacting an alkaline clonixate with 1-bromo-4-chlorobonate in acetonitrile. 4-Nitroxybutyl (I) clonixate is especially useful as an active ingredient for the treatment of pain and / or inflammation in mammals (graphic).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP972226 ECSP972226A (en) | 1997-08-14 | 1997-08-14 | NON-ULCEROGENIC ANTI-INFLAMMATORY ANALGESIC DERIVATIVE OF CLONIXINE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP972226 ECSP972226A (en) | 1997-08-14 | 1997-08-14 | NON-ULCEROGENIC ANTI-INFLAMMATORY ANALGESIC DERIVATIVE OF CLONIXINE |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP972226A true ECSP972226A (en) | 1998-11-23 |
Family
ID=42043057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP972226 ECSP972226A (en) | 1997-08-14 | 1997-08-14 | NON-ULCEROGENIC ANTI-INFLAMMATORY ANALGESIC DERIVATIVE OF CLONIXINE |
Country Status (1)
Country | Link |
---|---|
EC (1) | ECSP972226A (en) |
-
1997
- 1997-08-14 EC ECSP972226 patent/ECSP972226A/en unknown
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