AR009241A1 - THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE - Google Patents
THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDUREInfo
- Publication number
- AR009241A1 AR009241A1 ARP970103688A AR009241A1 AR 009241 A1 AR009241 A1 AR 009241A1 AR P970103688 A ARP970103688 A AR P970103688A AR 009241 A1 AR009241 A1 AR 009241A1
- Authority
- AR
- Argentina
- Prior art keywords
- clonixate
- compound
- nitroxybutyl
- procedure
- treatment method
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
El derivado de clonixina de formula (I), o clonixato de 4-nitroxibutilo, es un nuevo producto analgésico-antiinflamatorio no esteroideo, que tiene unequilibrio extraordinariamente bueno entre una alta actividad analgésica/ antiinflamatoria ybajos efectos adversos ulcerogénicos, principalmente comouna consecuencia de una sorprendentemente alta actividad antiinflamatoria (dos veces la del ácido clonixínico). El compuesto (I) se prepara haciendoreaccionar el clonixato de 4-clorobutilo con nitrato de plata en acetonitrilo. El clonixato de 4-clorobutilo se prepara por reaccion de un clonixato alcalinocon 1-bromo-4-clorobutano en acetonitrilo. El clonixato de 4-nitroxibutilo (I) es especialmente util como principio activo para el tratamiento del dolor y/oinflamacion en mamíferos.The clonixin derivative of formula (I), or 4-nitroxybutyl clonixate, is a new non-steroidal analgesic-anti-inflammatory product, which has an extraordinarily good balance between high analgesic / anti-inflammatory activity and low ulcerogenic side effects, mainly as a consequence of a surprisingly high anti-inflammatory activity (twice that of clonixinic acid). Compound (I) is prepared by reacting the 4-chlorobutyl clonixate with silver nitrate in acetonitrile. The 4-chlorobutyl clonixate is prepared by reacting an alkaline clonixate with 1-bromo-4-chlorobutane in acetonitrile. 4-Nitroxybutyl (I) clonixate is especially useful as an active ingredient for the treatment of pain and / or inflammation in mammals.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP970103688 AR009241A1 (en) | 1997-08-13 | 1997-08-13 | THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP970103688 AR009241A1 (en) | 1997-08-13 | 1997-08-13 | THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE |
Publications (1)
Publication Number | Publication Date |
---|---|
AR009241A1 true AR009241A1 (en) | 2000-04-12 |
Family
ID=45724523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970103688 AR009241A1 (en) | 1997-08-13 | 1997-08-13 | THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE |
Country Status (1)
Country | Link |
---|---|
AR (1) | AR009241A1 (en) |
-
1997
- 1997-08-13 AR ARP970103688 patent/AR009241A1/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT97689A (en) | PROCESS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS INCORPORATING AS ACTIVE INGREDIENT ISOXAZOL-4-CARBOXYLAMIDE AND HYDROXYLYLIDENE-CYANOOCETAMIDE | |
HK1085390A1 (en) | Solution for ungual and peri-ungual application and its use in preparation of a medicament treating dermatological diseases | |
WO1999063826A3 (en) | Agents for combating plant pests | |
DK0971705T3 (en) | Hormone replacement therapy drug formulations for topical application to the skin | |
ATE254110T1 (en) | ANTIPROLIFERATIVE IMIDAZOLE ACTIVE INGREDIENTS | |
EA200100458A1 (en) | Antiparasitic drugs | |
WO2001041550A3 (en) | Topical anesthetic formulation | |
AU2002214389A1 (en) | Pharmaceutical composition containing honey for the treatment of wounds | |
SE9802208D0 (en) | Novel compounds | |
EP0974363A4 (en) | Remedies for drug addiction | |
DK1893237T3 (en) | Pharmaceutical composition comprising an organopolysiloxane elastomer and a solubilized active substance | |
ECSP930933A (en) | PHARMACEUTICAL COMPOSITION AND PROCEDURE FOR PREPARING IT | |
TR200003156T2 (en) | Therapeutic anti-cold agent containing isomalt as an active ingredient. | |
SE0002476D0 (en) | New compounds | |
CA2417935A1 (en) | Anti-inflammatory medicament | |
ES2137125B1 (en) | THE USE OF THE ZINC SALT OF THE GLICIRRETIC ACID IN PREPARATIONS AGAINST ACNE AND THE COMPOSITIONS CONTAINING SUCH SALT. | |
BR9913982A (en) | Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases | |
BR0013283A (en) | Pharmaceutical agent comprising a benzamide derivative as active ingredient | |
AR009241A1 (en) | THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE | |
CO4900065A1 (en) | NON-ULCEROGENIC ANALGESIC / ANTI-INFLAMMATORY DERIVATIVE OF CLONIXINE | |
ECSP972226A (en) | NON-ULCEROGENIC ANTI-INFLAMMATORY ANALGESIC DERIVATIVE OF CLONIXINE | |
IT1306147B1 (en) | DERIVATIVES OF ACTIVE INGREDIENTS FOR THERAPEUTIC AND / OR NUTRITIONAL ACTIVITIES AND COMPOSITIONS SUITABLE FOR ORAL ADMINISTRATION CONTAINING SUCH | |
MXPA01007705A (en) | Benzamide derivatives and drugs containing the same. | |
DE59101818D1 (en) | Pharmaceutical preparation containing stigmasta-4-en-3-one and their use. | |
DK0742716T3 (en) | Pharmaceutical composition for systemic transdermal administration with the morphine-6-glucuronide active agent |