AR009241A1 - THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE - Google Patents

THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE

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Publication number
AR009241A1
AR009241A1 ARP970103688A AR009241A1 AR 009241 A1 AR009241 A1 AR 009241A1 AR P970103688 A ARP970103688 A AR P970103688A AR 009241 A1 AR009241 A1 AR 009241A1
Authority
AR
Argentina
Prior art keywords
clonixate
compound
nitroxybutyl
procedure
treatment method
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Handforth Invest Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Handforth Invest Ltd filed Critical Handforth Invest Ltd
Priority to ARP970103688 priority Critical patent/AR009241A1/en
Publication of AR009241A1 publication Critical patent/AR009241A1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

El derivado de clonixina de formula (I), o clonixato de 4-nitroxibutilo, es un nuevo producto analgésico-antiinflamatorio no esteroideo, que tiene unequilibrio extraordinariamente bueno entre una alta actividad analgésica/ antiinflamatoria ybajos efectos adversos ulcerogénicos, principalmente comouna consecuencia de una sorprendentemente alta actividad antiinflamatoria (dos veces la del ácido clonixínico). El compuesto (I) se prepara haciendoreaccionar el clonixato de 4-clorobutilo con nitrato de plata en acetonitrilo. El clonixato de 4-clorobutilo se prepara por reaccion de un clonixato alcalinocon 1-bromo-4-clorobutano en acetonitrilo. El clonixato de 4-nitroxibutilo (I) es especialmente util como principio activo para el tratamiento del dolor y/oinflamacion en mamíferos.The clonixin derivative of formula (I), or 4-nitroxybutyl clonixate, is a new non-steroidal analgesic-anti-inflammatory product, which has an extraordinarily good balance between high analgesic / anti-inflammatory activity and low ulcerogenic side effects, mainly as a consequence of a surprisingly high anti-inflammatory activity (twice that of clonixinic acid). Compound (I) is prepared by reacting the 4-chlorobutyl clonixate with silver nitrate in acetonitrile. The 4-chlorobutyl clonixate is prepared by reacting an alkaline clonixate with 1-bromo-4-chlorobutane in acetonitrile. 4-Nitroxybutyl (I) clonixate is especially useful as an active ingredient for the treatment of pain and / or inflammation in mammals.

ARP970103688 1997-08-13 1997-08-13 THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE AR009241A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP970103688 AR009241A1 (en) 1997-08-13 1997-08-13 THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP970103688 AR009241A1 (en) 1997-08-13 1997-08-13 THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE

Publications (1)

Publication Number Publication Date
AR009241A1 true AR009241A1 (en) 2000-04-12

Family

ID=45724523

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103688 AR009241A1 (en) 1997-08-13 1997-08-13 THE 4-NITROXYBUTYL CLONIXATE COMPOUND, A CONTAINING COMPOSITION, ITS USE, TREATMENT METHOD USING IT, A PREPARATION PROCEDURE AND AN INTERMEDIATE COMPOUND OF SUCH PROCEDURE

Country Status (1)

Country Link
AR (1) AR009241A1 (en)

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