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Priority to ECSP972208priorityCriticalpatent/ECSP972208A/en
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur
(AREA)
Abstract
Se describen nuevos compuestos triciclos de N-cianoimina y composiciones farmacéuticas que son inhibidores de la enzima, transferasa de proteina farnseilo. Asi mismo se describe un método para inhibir la función Ras y por lo tanto para inhibir el desarrollo anormal de células. El método comprende administrar los nuevos compuestos N-cianoiminas triciclicas a un sistema biológico. En particular el método inhibe el desarrollo anormal de células en mamíferos tales como un ser humano.Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions are described that are inhibitors of the enzyme, farnseyl protein transferase. Likewise, a method is described to inhibit Ras function and therefore to inhibit abnormal cell development. The method comprises administering the new tricyclic N-cyanoimine compounds to a biological system. In particular, the method inhibits abnormal cell development in mammals such as a human.
ECSP9722081997-07-301997-07-30
NEW TRICYCLIC CYANOIMINS AND USEFUL AS PROTEIN TRANSFERASE INHIBITORS FARNESILO
ECSP972208A
(en)
TRICYCLIC UREA COMPOUNDS USEFUL FOR THE INHIBITION OF THE FUNCTION OF PROTEIN G AND FOR THE TREATMENT OF PROTEOLYTIC DISEASES, PHARMACEUTICAL COMPOSITION, AND THE USE OF THE SAME FOR THE PREPARATION OF MEDICINES.
TRICYCLIC COMPOUNDS USEFUL TO INHIBIT THE FUNCTION OF PROTEIN G AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF MEDICINES
BENZOILGUANIDINES SUBSTITUTED WITH GROUPS OF BASIC CHARACTER, PROCEDURE FOR THEIR PREPARATION, ITS USE AS A MEDICATION OR DIAGNOSTIC AGENT, AS WELL AS A MEDICINAL PRODUCT CONTAINING THEM.
NEW DERIVATIVES PSEUDOPEPTIDICOS OF ANTAGONIST ACTIVITY OF BRADIQUININA, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.