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Acyclic And Carbocyclic Compounds In Medicinal Compositions
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Organic Low-Molecular-Weight Compounds And Preparation Thereof
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Abstract
Retinoides de fórmula general (gráfico), en donde X1 es oxo o un grupo OR1 en la posición 4 ó 5; R1 es hidrógeno, alquilo o acilo; y R2 es hidrógeno o alquilo; los enlaces punteados son opcionalmente y un enlace doble 3,4 puede solamente estar presente cuando X está en la posición 5; así como las sales farmacéuticamente aceptables de los ácidos carboxílicos de fórmula Y, pueden emplearse para la terapia y profilaxis de transtornos dermatológicos que van acompañados de lesiones epiteliales, p ej. el acné y la psoriasis, así como lesiones epiteliales malignas, tumores y cambios precancerosos de la membrana de las mucosas de la boca, lengua, laringe, esófago, vejiga, cervix y colón.Retinoids of general formula (graph), wherein X1 is oxo or an OR1 group at position 4 or 5; R1 is hydrogen, alkyl or acyl; and R2 is hydrogen or alkyl; dotted bonds are optionally and a 3,4 double bond can only be present when X is in position 5; as well as the pharmaceutically acceptable salts of the carboxylic acids of formula Y, can be used for the therapy and prophylaxis of dermatological disorders that are accompanied by epithelial lesions, eg. acne and psoriasis, as well as malignant epithelial lesions, tumors, and precancerous changes of the mucous membrane of the mouth, tongue, larynx, esophagus, bladder, cervix, and colon.
PROCEDURE FOR THE PREPARATION OF TIOTROPIO BROMIDE AND USE OF TROPENOL AND TROPENOLIC ESTER AS STARTING MATERIALS FOR THE PREPARATION OF TIOTROPIO BROMIDE