ECSP961875A - CEPHALOSPORIN DERIVATIVES (CASE RAN 4410/248 K) - Google Patents
CEPHALOSPORIN DERIVATIVES (CASE RAN 4410/248 K)Info
- Publication number
- ECSP961875A ECSP961875A ECSP961875A ECSP961875A EC SP961875 A ECSP961875 A EC SP961875A EC SP961875 A ECSP961875 A EC SP961875A EC SP961875 A ECSP961875 A EC SP961875A
- Authority
- EC
- Ecuador
- Prior art keywords
- substituted
- lower alkyl
- hydroxyphenyl
- fluoro
- compounds
- Prior art date
Links
Abstract
El invento se refiere a derivados de cefalosporina de la fórmula (gráfico), en donde: R1 es un grupo elegido entre 2-,3- y 4- hidroxifenilo, 2- y 3-metoxifenilo, 4-carboxifenilo, 4-carbamoilfenilo, 3-trifluorometilfenilo, 2- y 3-fluoro-fenilo, 3-nitrofenilo, 3-fluoro-4-hidroxifenilo, 2-fluoro-4-hidroxifenilo, 3-fluoro -2 hidroxifenilo, 3-4-dihidroxifenilo, bencilo, CHR-fenilo, 3-hidroxibencilo, 4-amino-bencilo, 2- 3- y 4-fluorobencilo, 4-trifluorometilbencilo, 1-naftilo y 2-naftilo, estando todos los sustituyentes hidroxilo, amino, carboxilo y carbamoilo opcionalmente sustituidos, o es piridinlo mono-sustituido por halógenom pirimidilo, piracinilo di-sustituido por alquilo inferior, piridacinilo mono-sustituido por halógeno, piperidinilo en donde el grupo amino puede estar sustituido por un grupo acilo, tiadiazolilo, oxo-tetra-hidrofuranilo, tiofenilo mono-sustituido por alcoxicarbonilo inferior o carbamoilo, tetrazolil-alquilo inferior, tetrahidrofuranil-alquilo inferior, tiofenil alquilo inferior o bencimidazolil-alquilo inferior; y R es carboxilo o carboxilo esterificado; sus esteres fácilmente hidrolizables, sales farmacéuticamente aceptables de dichos compuestos e hidratos de los compuestos de fórmula I y de sus ésteres y sales, asi como su empleo y el procediemto para la preparación de estos compuestos.The invention relates to cephalosporin derivatives of the formula (graph), wherein: R1 is a group chosen from 2-, 3- and 4- hydroxyphenyl, 2- and 3-methoxyphenyl, 4-carboxyphenyl, 4-carbamoylphenyl, 3 -trifluoromethylphenyl, 2- and 3-fluoro-phenyl, 3-nitrophenyl, 3-fluoro-4-hydroxyphenyl, 2-fluoro-4-hydroxyphenyl, 3-fluoro -2 hydroxyphenyl, 3-4-dihydroxyphenyl, benzyl, CHR-phenyl , 3-hydroxybenzyl, 4-amino-benzyl, 2- 3- and 4-fluorobenzyl, 4-trifluoromethylbenzyl, 1-naphthyl and 2-naphthyl, with all hydroxyl, amino, carboxyl and carbamoyl substituents being optionally substituted, or is pyridinyl mono -substituted by halogen pyrimidyl, pyrazinyl di-substituted by lower alkyl, pyridacinyl mono-substituted by halogen, piperidinyl wherein the amino group may be substituted by an acyl group, thiadiazolyl, oxo-tetra-hydrofuranyl, thiophenyl mono-substituted by lower alkoxycarbonyl or carbamoyl, tetrazolyl-lower alkyl, tetrahydrofuranyl-lower alkyl, thiophenyl lower alkyl or benzimidazolyl-lower alkyl; and R is carboxyl or esterified carboxyl; their easily hydrolyzable esters, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and their esters and salts, as well as their use and the process for the preparation of these compounds.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP961875 ECSP961875A (en) | 1996-09-12 | 1996-09-12 | CEPHALOSPORIN DERIVATIVES (CASE RAN 4410/248 K) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP961875 ECSP961875A (en) | 1996-09-12 | 1996-09-12 | CEPHALOSPORIN DERIVATIVES (CASE RAN 4410/248 K) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP961875A true ECSP961875A (en) | 1997-12-09 |
Family
ID=42042601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP961875 ECSP961875A (en) | 1996-09-12 | 1996-09-12 | CEPHALOSPORIN DERIVATIVES (CASE RAN 4410/248 K) |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP961875A (en) |
-
1996
- 1996-09-12 EC ECSP961875 patent/ECSP961875A/en unknown
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