AR005864A1 - DERIVATIVES OF CAFALOSPORIN, ITS EMPLOYMENT, PROCEDURE TO PREPARE THEM, A PHARMACEUTICAL PREPARATION CONTAINING SUCH A DERIVATIVE AND USEFUL COMPOUNDS TO PREPARE SUCH DERIVATIVES. - Google Patents
DERIVATIVES OF CAFALOSPORIN, ITS EMPLOYMENT, PROCEDURE TO PREPARE THEM, A PHARMACEUTICAL PREPARATION CONTAINING SUCH A DERIVATIVE AND USEFUL COMPOUNDS TO PREPARE SUCH DERIVATIVES.Info
- Publication number
- AR005864A1 AR005864A1 ARP960104287A ARP960104287A AR005864A1 AR 005864 A1 AR005864 A1 AR 005864A1 AR P960104287 A ARP960104287 A AR P960104287A AR P960104287 A ARP960104287 A AR P960104287A AR 005864 A1 AR005864 A1 AR 005864A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- substituted
- lower alkyl
- prepare
- hydroxyphenyl
- Prior art date
Links
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- Cephalosporin Compounds (AREA)
Abstract
Derivados de cefalosporina de la fórmula general (I), en donde: R1 es un grupo elegido entre 2-,3- y 4-hidroxifenilo, 2- y 3-metoxifenilo, 4-carboxifenilo, 4-carbamoilfenilo, 3-trifluorometilfenilo, 2- y 3-fluoro-fenilo, 3-nitrofenilo,3-fluoro-4- hidroxifenilo, 2-fluoro-4-hidroxifenilo, 3-fluoro-2-hidroxifenilo, 3-,4-dihidroxi-fenilo, bencilo, -CHR-fenilo, 3-hidroxibencilo, 4-amino-bencilo, 2-, 3- y 4-fluorobencilo, 2-, 3- y 4-metoxibencilo, 4-nitrobencilo, 4-carboxibencilo,4-trifluorometi lbencilo, 1-naftilo y 2-naftilo, estando todos los sustituyentes hidroxilo, amino, carboxilo y carbamoiloopcionalmente sustituidos, o es piridinilo mono-sustituido por halógeno, pirimidilo, piracinilo di sustituido por alquiloinferior, pirida cinilo mono-sustituido por halógeno, piperidinilo en donde el grupo amino puede estar sustituido por un grupo acilo, tiadiazolilo, oxotetrahidrofuranilo, tiofenilomono-sustituido por alcoxicarbonil inferior o carbamoilo,tetrazolil-alquilo i nferior, tetrahidrofuranil-alquil inferior, tiofenil-alquilo inferior obencimidazolil-alquilo inferior; y R es carboxilo o carboxilo esterificado; sus ésteres fácilmente hidrolizables, sales farmacéuticamente aceptables dedichosderivados e hidratos de los derivados de fórmula (I) y de sus ésteres y sales, así como a su empleo, al procedimiento para la preparación de estos derivados,a un preparado farmacéutico que contiene tal derivado y a compuestos útiles parapreparar dichos derivados.Cephalosporin derivatives of the general formula (I), wherein: R1 is a group chosen from 2-, 3- and 4-hydroxyphenyl, 2- and 3-methoxyphenyl, 4-carboxyphenyl, 4-carbamoylphenyl, 3-trifluoromethylphenyl, 2 - and 3-fluoro-phenyl, 3-nitrophenyl, 3-fluoro-4-hydroxyphenyl, 2-fluoro-4-hydroxyphenyl, 3-fluoro-2-hydroxyphenyl, 3-, 4-dihydroxy-phenyl, benzyl, -CHR- phenyl, 3-hydroxybenzyl, 4-amino-benzyl, 2-, 3- and 4-fluorobenzyl, 2-, 3- and 4-methoxybenzyl, 4-nitrobenzyl, 4-carboxybenzyl, 4-trifluoromethylbenzyl, 1-naphthyl and 2 -naphthyl, with all hydroxyl, amino, carboxyl and carbamoyl substituents being optionally substituted, or is mono-substituted halogen-pyridinyl, lower alkyl-substituted di-pyrinyl, mono-halogen-substituted pyridinyl, piperidinyl where the amino group may be substituted by an acyl group, thiadiazolyl, oxotetrahydrofuranyl, thiophenylomono-substituted by lower alkoxycarbonyl or carbamoyl, tetrazolyl-lower alkyl, tetrahydr ofuranyl-lower alkyl, thiophenyl-lower alkyl obenzimidazolyl-lower alkyl; and R is carboxyl or esterified carboxyl; their easily hydrolyzable esters, pharmaceutically acceptable salts of said derivatives and hydrates of the derivatives of formula (I) and their esters and salts, as well as their use, the process for the preparation of these derivatives, a pharmaceutical preparation containing such a derivative and useful compounds to prepare said derivatives.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9511430.2A GB9511430D0 (en) | 1995-06-06 | 1995-06-06 | Storage containers |
| EP95114303 | 1995-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005864A1 true AR005864A1 (en) | 1999-07-21 |
Family
ID=51929400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104287A AR005864A1 (en) | 1995-06-06 | 1996-10-09 | DERIVATIVES OF CAFALOSPORIN, ITS EMPLOYMENT, PROCEDURE TO PREPARE THEM, A PHARMACEUTICAL PREPARATION CONTAINING SUCH A DERIVATIVE AND USEFUL COMPOUNDS TO PREPARE SUCH DERIVATIVES. |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR005864A1 (en) |
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1996
- 1996-10-09 AR ARP960104287A patent/AR005864A1/en unknown
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