ECSP961759A - 5,6 DIHYDRO -9H- PYRAZOLE (3,4-C) -1,2,4- TRIAZOLE (4- 3 -A) TRICYCLIC PIRIDINES - Google Patents

5,6 DIHYDRO -9H- PYRAZOLE (3,4-C) -1,2,4- TRIAZOLE (4- 3 -A) TRICYCLIC PIRIDINES

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Publication number
ECSP961759A
ECSP961759A ECSP961759A ECSP961759A EC SP961759 A ECSP961759 A EC SP961759A EC SP961759 A ECSP961759 A EC SP961759A EC SP961759 A ECSP961759 A EC SP961759A
Authority
EC
Ecuador
Prior art keywords
tnf
tricyclic
triazole
dihydro
diseases
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Allen Jacob Duplantier
Kelvin Cooper
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP961759 priority Critical patent/ECSP961759A/en
Publication of ECSP961759A publication Critical patent/ECSP961759A/en

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Abstract

Esta invención se refiere a 5,6-dihidro-9H-pirazol [3,4-c]-1,2,4-triazol [4,3-a] piridinas tricíclicas que son inhibidores selectivos de fosfodiesterasa (PDE) tipo IV o de la producción de factor necrosis de tumor (TNF) y como tales son útiles en el tratamiento de asma, artritis, bronquitis, enfermedad de las vías respiratorias obstructiva crónica, psoriasis, rinitis alérgica, dermatitis y otras enfermedades inflamatorias, asi como de SIDA, septicemia, choque sético y otras enfermedades, tales como caquexia, que implican la producción de TNF. Los compuestos de la presente invención pueden tener actividad inhibidora combinada de PDE IV y TNF. Esta invención se refiere a un procedimiento de uso de tales compuestos en el tratamiento de las anetriores enfermedades en mamíferos, especialmenrte humanos y a composiciones farmacéuticas útiles para el mismo.This invention relates to tricyclic 5,6-dihydro-9H-pyrazol [3,4-c] -1,2,4-triazole [4,3-a] pyridines that are selective inhibitors of type IV phosphodiesterase (PDE) or of the production of tumor necrosis factor (TNF) and as such are useful in the treatment of asthma, arthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases, as well as AIDS, septicemia, septic shock and other diseases, such as cachexia, that involve the production of TNF. The compounds of the present invention may have combined PDE IV and TNF inhibitory activity. This invention relates to a method of using such compounds in the treatment of previous diseases in mammals, especially humans, and to pharmaceutical compositions useful therefor.

ECSP961759 1996-05-23 1996-05-23 5,6 DIHYDRO -9H- PYRAZOLE (3,4-C) -1,2,4- TRIAZOLE (4- 3 -A) TRICYCLIC PIRIDINES ECSP961759A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP961759 ECSP961759A (en) 1996-05-23 1996-05-23 5,6 DIHYDRO -9H- PYRAZOLE (3,4-C) -1,2,4- TRIAZOLE (4- 3 -A) TRICYCLIC PIRIDINES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP961759 ECSP961759A (en) 1996-05-23 1996-05-23 5,6 DIHYDRO -9H- PYRAZOLE (3,4-C) -1,2,4- TRIAZOLE (4- 3 -A) TRICYCLIC PIRIDINES

Publications (1)

Publication Number Publication Date
ECSP961759A true ECSP961759A (en) 1997-09-22

Family

ID=42042489

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP961759 ECSP961759A (en) 1996-05-23 1996-05-23 5,6 DIHYDRO -9H- PYRAZOLE (3,4-C) -1,2,4- TRIAZOLE (4- 3 -A) TRICYCLIC PIRIDINES

Country Status (1)

Country Link
EC (1) ECSP961759A (en)

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