ECSP14008829A - TRANSDERMAL ADMINISTRATION SYSTEM - Google Patents
TRANSDERMAL ADMINISTRATION SYSTEMInfo
- Publication number
- ECSP14008829A ECSP14008829A ECIEPI20148829A ECPI201408829A ECSP14008829A EC SP14008829 A ECSP14008829 A EC SP14008829A EC IEPI20148829 A ECIEPI20148829 A EC IEPI20148829A EC PI201408829 A ECPI201408829 A EC PI201408829A EC SP14008829 A ECSP14008829 A EC SP14008829A
- Authority
- EC
- Ecuador
- Prior art keywords
- buprenorphine
- adhesive layer
- acid
- sensitive adhesive
- layer
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a sistema terapéutico transdérmico para la administración transdérmica de buprenorfina, que comprende una estructura de capa auto–adhesiva que contiene buprenorfina la cual comprende A) una capa de respaldo impermeable a buprenorfina, y B) una capa adhesiva sensible a la presión que contiene buprenorfina sobre dicha capa de respaldo impermeable a la buprenorfina, donde la capa adhesiva comprende a) al menos un adhesivo sensible a la presión de base polimérica, b) una cantidad analgésicamente efectiva de base de buprenorfina o una sal farmacéuticamente aceptable de la misma, y c) un ácido carboxílico seleccionado del grupo que consiste de ácido oleico, ácido linoléico, ácido linolénico, ácido levulínico y mezclas de los mismos, en una cantidad suficiente de modo que dicha cantidad analgésicamente efectiva de buprenorfina se solubiliza en él, para formar una mezcla, y la mezcla de ácido carboxílico con buprenorfina forma depósitos dispersos en dicho adhesivo sensible a la presión, donde dicha capa adhesiva sensible a la presión que contiene buprenorfina es la capa que contacta la piel.The invention relates to a transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing self-adhesive layer structure which comprises A) a buprenorphine-impermeable backing layer, and B) a pressure-sensitive adhesive layer. containing buprenorphine on said buprenorphine-impermeable backing layer, wherein the adhesive layer comprises a) at least one polymer-based pressure-sensitive adhesive, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof , and c) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid, linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein, to form a mixture, and the mixture of carboxylic acid with buprenorphine forms dispersed deposits in said adhesive sensi buprenorphine-containing pressure sensitive adhesive layer is the layer that contacts the skin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569609P | 2011-12-12 | 2011-12-12 | |
| CH2012002973 | 2012-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP14008829A true ECSP14008829A (en) | 2015-07-31 |
Family
ID=73005797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI20148829A ECSP14008829A (en) | 2011-12-12 | 2014-07-10 | TRANSDERMAL ADMINISTRATION SYSTEM |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP14008829A (en) |
-
2014
- 2014-07-10 EC ECIEPI20148829A patent/ECSP14008829A/en unknown
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