ECSP13012891A - HETEROARILO DERIVATIVES AS MODULATORS OF NACHR ALFA 7 - Google Patents
HETEROARILO DERIVATIVES AS MODULATORS OF NACHR ALFA 7Info
- Publication number
- ECSP13012891A ECSP13012891A ECSP13012891A ECSP13012891A EC SP13012891 A ECSP13012891 A EC SP13012891A EC SP13012891 A ECSP13012891 A EC SP13012891A EC SP13012891 A ECSP13012891 A EC SP13012891A
- Authority
- EC
- Ecuador
- Prior art keywords
- analogs
- heteroarilo
- nachr
- alfa
- modulators
- Prior art date
Links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract
Se divulga un compuesto de la fórmula (I), en donde Z, m y R1-R6 se describen en la misma, como un modulador de receptores de acetilcolina nicotínica particularmente del subtipo ?7, en un sujeto en necesidad del mismo, así como sus análogos, profármacos, análogos isotópicamente sustituidos, metabolitos, sales farmacéuticamente aceptables, polimorfos, solvatos, isómeros, clatratos y co-cristales, para su uso ya sea solos o en combinaciones con otros medicamentos adecuados, y composiciones farmacéuticas que contienen dichos compuestos y análogos. También se divulgan un proceso de preparación de los compuestos y sus usos pretendidos en terapia, particularmente en la profilaxis y terapia de trastornos tales como la enfermedad de Alzheimer, deterioro cognitivo leve, demencia senil, y similares.A compound of the formula (I) is disclosed, wherein Z, m and R1-R6 are described therein, as a modulator of nicotinic acetylcholine receptors particularly of the subtype? 7, in a subject in need thereof, as well as its analogs, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates and co-crystals, for use either alone or in combinations with other suitable medicaments, and pharmaceutical compositions containing said compounds and analogs. A process for preparing the compounds and their intended uses in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like are also disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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IN242KO2011 | 2011-02-23 | ||
IN1184KO2011 | 2011-09-09 |
Publications (1)
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ECSP13012891A true ECSP13012891A (en) | 2013-10-31 |
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ECSP13012891 ECSP13012891A (en) | 2011-02-23 | 2013-09-20 | HETEROARILO DERIVATIVES AS MODULATORS OF NACHR ALFA 7 |
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US (2) | US9072731B2 (en) |
EP (1) | EP2678327B9 (en) |
JP (1) | JP6118270B2 (en) |
KR (1) | KR20140026378A (en) |
CN (1) | CN103402994B (en) |
AP (1) | AP3649A (en) |
AU (1) | AU2012221800B2 (en) |
BR (1) | BR112013021602A2 (en) |
CA (1) | CA2826792A1 (en) |
CL (1) | CL2013002449A1 (en) |
CO (1) | CO6761374A2 (en) |
CR (1) | CR20130415A (en) |
CU (1) | CU24177B1 (en) |
CY (1) | CY1118107T1 (en) |
DK (1) | DK2678327T3 (en) |
DO (1) | DOP2013000191A (en) |
EA (1) | EA024170B1 (en) |
EC (1) | ECSP13012891A (en) |
ES (1) | ES2594409T3 (en) |
GE (1) | GEP20156318B (en) |
GT (1) | GT201300207A (en) |
HR (1) | HRP20161481T1 (en) |
HU (1) | HUE030659T2 (en) |
IL (1) | IL228052A (en) |
LT (1) | LT2678327T (en) |
MA (1) | MA34957B1 (en) |
MX (1) | MX343788B (en) |
NI (1) | NI201300072A (en) |
PE (1) | PE20140703A1 (en) |
PL (1) | PL2678327T3 (en) |
RS (1) | RS55433B1 (en) |
SG (1) | SG192625A1 (en) |
SI (1) | SI2678327T1 (en) |
SM (1) | SMT201600409B (en) |
WO (1) | WO2012114285A1 (en) |
ZA (1) | ZA201306223B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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PL2678327T3 (en) | 2011-02-23 | 2017-02-28 | Lupin Limited | Heteroaryl derivatives as alpha7 nachr modulators |
WO2013132380A1 (en) | 2012-03-06 | 2013-09-12 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
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