ECSP055870A - TETRAHYDROQUINOLINE DERIVATIVES - Google Patents
TETRAHYDROQUINOLINE DERIVATIVESInfo
- Publication number
- ECSP055870A ECSP055870A EC2005005870A ECSP055870A ECSP055870A EC SP055870 A ECSP055870 A EC SP055870A EC 2005005870 A EC2005005870 A EC 2005005870A EC SP055870 A ECSP055870 A EC SP055870A EC SP055870 A ECSP055870 A EC SP055870A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- amino
- alkylamino
- derivatives
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a derivados de tetrahidroquinolina de la fórmula general (I) o a su sal farmacéuticamente aceptable, en donde R1 y R2 son H, Me; R3 es (2-6C)heterocicloalquil(1-4C)alquilo, (2-5C)heteroaril(1-4C)alquilo, (6C)aril(1-4C)alquilo, (1-4C)(di)alquilaminocarbonilamino(2-4C)alquilo, (2-6C)heterocicloalquilcarbonilamino(2-4C)alquilo, R5-(2-4C)alquilo o R5-carbonil(1-4C)alquilo; R4 es (2-5C)heteroarilo, (6C)arilo, (3-8C)cicloalquilo, (2-6C)heterocicloalquilo o (1-6C)alquilo y R5 es (di)(1-4C)alquilamino, (1-4C)alcoxi, amino, hidroxi, (6C)arilamino, (di)(3-4C)alquenilamino, (2-5C)heteroaril(1-4C)alquilamino, (6C)aril(1-4C)alquilamino, (di) (1-4C)alcoxi(2-4C)alquil amino, di (1-4C)alquilamino(2-4C)alquil amino, (di) amino(2-4C)alquil amino o (di) hidroxi(2-4C)alquil amino. La presente invención también se refiere a composiciones farmacéuticas que comprenden dichos derivados y al uso de estos derivados para regular la fertilidad.The present invention relates to tetrahydroquinoline derivatives of the general formula (I) or their pharmaceutically acceptable salt, wherein R1 and R2 are H, Me; R3 is (2-6C) heterocycloalkyl (1-4C) alkyl, (2-5C) heteroaryl (1-4C) alkyl, (6C) aryl (1-4C) alkyl, (1-4C) (di) alkylaminocarbonylamino (2 -4C) alkyl, (2-6C) heterocycloalkylcarbonylamino (2-4C) alkyl, R5- (2-4C) alkyl or R5-carbonyl (1-4C) alkyl; R4 is (2-5C) heteroaryl, (6C) aryl, (3-8C) cycloalkyl, (2-6C) heterocycloalkyl or (1-6C) alkyl and R5 is (di) (1-4C) alkylamino, (1- 4C) alkoxy, amino, hydroxy, (6C) arylamino, (di) (3-4C) alkenylamino, (2-5C) heteroaryl (1-4C) alkylamino, (6C) aryl (1-4C) alkylamino, (di) (1-4C) alkoxy (2-4C) alkyl amino, di (1-4C) alkylamino (2-4C) alkyl amino, (di) amino (2-4C) alkyl amino or (di) hydroxy (2-4C) alkyl amino. The present invention also relates to pharmaceutical compositions comprising said derivatives and the use of these derivatives to regulate fertility.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43547902P | 2002-12-20 | 2002-12-20 | |
EP02102865 | 2002-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP055870A true ECSP055870A (en) | 2005-09-20 |
Family
ID=32683820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2005005870A ECSP055870A (en) | 2002-12-20 | 2005-06-20 | TETRAHYDROQUINOLINE DERIVATIVES |
Country Status (8)
Country | Link |
---|---|
KR (1) | KR20050085694A (en) |
CO (1) | CO5590955A2 (en) |
CY (1) | CY1107980T1 (en) |
EC (1) | ECSP055870A (en) |
HK (1) | HK1077576A1 (en) |
HR (1) | HRP20050577A2 (en) |
IS (1) | IS2553B (en) |
NO (1) | NO330640B1 (en) |
-
2003
- 2003-12-16 KR KR1020057011040A patent/KR20050085694A/en active IP Right Grant
-
2005
- 2005-05-26 IS IS7870A patent/IS2553B/en unknown
- 2005-06-08 NO NO20052777A patent/NO330640B1/en not_active IP Right Cessation
- 2005-06-20 HR HR20050577A patent/HRP20050577A2/en not_active Application Discontinuation
- 2005-06-20 EC EC2005005870A patent/ECSP055870A/en unknown
- 2005-07-19 CO CO05071354A patent/CO5590955A2/en not_active Application Discontinuation
- 2005-12-28 HK HK05112053A patent/HK1077576A1/en not_active IP Right Cessation
-
2008
- 2008-06-02 CY CY20081100568T patent/CY1107980T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO20052777L (en) | 2005-07-13 |
KR20050085694A (en) | 2005-08-29 |
NO330640B1 (en) | 2011-05-30 |
CO5590955A2 (en) | 2005-12-30 |
CY1107980T1 (en) | 2013-09-04 |
HRP20050577A2 (en) | 2005-12-31 |
HK1077576A1 (en) | 2006-02-17 |
IS7870A (en) | 2005-05-26 |
IS2553B (en) | 2009-10-15 |
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