CO5590955A2 - DERIVATIVES OF TETRAHYDROQUINOLINE AND ITS USE AS FSH RECEPTOR MODULATORS - Google Patents

DERIVATIVES OF TETRAHYDROQUINOLINE AND ITS USE AS FSH RECEPTOR MODULATORS

Info

Publication number
CO5590955A2
CO5590955A2 CO05071354A CO05071354A CO5590955A2 CO 5590955 A2 CO5590955 A2 CO 5590955A2 CO 05071354 A CO05071354 A CO 05071354A CO 05071354 A CO05071354 A CO 05071354A CO 5590955 A2 CO5590955 A2 CO 5590955A2
Authority
CO
Colombia
Prior art keywords
alkyl
alkylamino
amino
derivative according
heteroaryl
Prior art date
Application number
CO05071354A
Other languages
Spanish (es)
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Karstens
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of CO5590955A2 publication Critical patent/CO5590955A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1.- Un derivado de tetrahidroquinolina de acuerdo con lafórmula I, o una sal farmacéuticamente aceptable de ésta, en donde R1 y R2 son H, Me;R3 es (2-6C) heterocicloalquil (1-4C) alquilo, (2-5C)heteroarilo(1-4C)alquilo, (6C)arilo(1-4C)alquilo, (1- 4C) (di) alquilaminocarbonilamino (2-4C) alquilo, (2- 6C) heterocicloalquilcarbonilamino (2-4C) alquilo, R5-(2-4C)alquilo o R5-carbonil(1-4C)alquilo;R4 es (2-5C) heteroarilo, (6C) arilo, (3-8C) cicloalquilo, (2-6C)heterocicloalquilo o (1-6C)alquilo R5 es (di)(1-4C) lquilamino, (1-4C) lcoxi, amino, hidroxi, (6C) rilamino, (di) 3-4C) lquenilamino, (2-5C) eteroarilo (1-4C) alquilamino, (6C) arilo (1-4C)alquilamino, (di) [(1-4C)alcoxi(2-4C)alquil]amino, (1-4C)alquilamino(2-4C)alquil]amino, (di) [amino(2-4C)alquil)amino o (di)hidroxi (2- 4C)alquil]amino. 2.- El derivado de acuerdo con la reivindicación 1 en dondeR3 es (2-6C)heterocicloalquil(1-4C)alquilo, (2-5C)heteroarilo(1-4C) alquilo, (2-6C)heterocicloalquilcarbonilamino (2-4C) alquilo, R5(2-4C)alquilo o R5-carbonil(1-4C)alquilo.3.- El derivado de acuerdo con las reivindicaciones 1 o 2 en donde R5 es (di)(1-4C)alquilamino, amino, (di) (3-4C)alquenilamino, (2-5C)heteroaril(1-4C)alquilamino o (6C)arilo(1-4C) alquilamino. 4.- El derivado de acuerdo con las reivindicaciones 1-3 en donde R5 es (di) (1-4C) alquilamino o amino.5.- El derivado de acuerdo con las reivindicaciones 1-4 en donde R5 es (di) (1-4C)alquilamino.6.- El derivado de acuerdo con las reivindicaciones 1-5 en donde R4 es (6C) arilo.7.- El derivado de acuerdo con las reivindicaciones 1-6 en donde R3 es (2-6C) heterocicloalquilo (1-4C) alquilo, (2-5C)heteroarilo(1-4C)alquilo o R5-(2-4C)alquilo.1. A tetrahydroquinoline derivative according to formula I, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are H, Me; R3 is (2-6C) heterocycloalkyl (1-4C) alkyl, (2-5C ) heteroaryl (1-4C) alkyl, (6C) aryl (1-4C) alkyl, (1-4C) (di) alkylaminocarbonylamino (2-4C) alkyl, (2-6C) heterocycloalkylcarbonylamino (2-4C) alkyl, R5 - (2-4C) alkyl or R5-carbonyl (1-4C) alkyl; R4 is (2-5C) heteroaryl, (6C) aryl, (3-8C) cycloalkyl, (2-6C) heterocycloalkyl or (1-6C ) R5 alkyl is (di) (1-4C) lkylamino, (1-4C) lkoxy, amino, hydroxy, (6C) rylamino, (di) 3-4C) lichenylamino, (2-5C) etheraryl (1-4C) alkylamino, (6C) aryl (1-4C) alkylamino, (di) [(1-4C) alkoxy (2-4C) alkyl] amino, (1-4C) alkylamino (2-4C) alkyl] amino, (di) [amino (2-4C) alkyl) amino or (di) hydroxy (2-4C) alkyl] amino. 2. The derivative according to claim 1 wherein R3 is (2-6C) heterocycloalkyl (1-4C) alkyl, (2-5C) heteroaryl (1-4C) alkyl, (2-6C) heterocycloalkylcarbonylamino (2-4C ) alkyl, R5 (2-4C) alkyl or R5-carbonyl (1-4C) alkyl. 3. The derivative according to claims 1 or 2 wherein R5 is (di) (1-4C) alkylamino, amino, (di) (3-4C) alkenylamino, (2-5C) heteroaryl (1-4C) alkylamino or (6C) aryl (1-4C) alkylamino. 4.- The derivative according to claims 1-3 wherein R5 is (di) (1-4C) alkylamino or amino.5.- The derivative according to claims 1-4 wherein R5 is (di) ( 1-4C) alkylamino.6.- The derivative according to claims 1-5 wherein R4 is (6C) aryl.7.- The derivative according to claims 1-6 wherein R3 is (2-6C) heterocycloalkyl (1-4C) alkyl, (2-5C) heteroaryl (1-4C) alkyl or R5- (2-4C) alkyl.

CO05071354A 2002-12-20 2005-07-19 DERIVATIVES OF TETRAHYDROQUINOLINE AND ITS USE AS FSH RECEPTOR MODULATORS CO5590955A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43547902P 2002-12-20 2002-12-20
EP02102865 2002-12-20

Publications (1)

Publication Number Publication Date
CO5590955A2 true CO5590955A2 (en) 2005-12-30

Family

ID=32683820

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05071354A CO5590955A2 (en) 2002-12-20 2005-07-19 DERIVATIVES OF TETRAHYDROQUINOLINE AND ITS USE AS FSH RECEPTOR MODULATORS

Country Status (8)

Country Link
KR (1) KR20050085694A (en)
CO (1) CO5590955A2 (en)
CY (1) CY1107980T1 (en)
EC (1) ECSP055870A (en)
HK (1) HK1077576A1 (en)
HR (1) HRP20050577A2 (en)
IS (1) IS2553B (en)
NO (1) NO330640B1 (en)

Also Published As

Publication number Publication date
IS7870A (en) 2005-05-26
HK1077576A1 (en) 2006-02-17
KR20050085694A (en) 2005-08-29
HRP20050577A2 (en) 2005-12-31
IS2553B (en) 2009-10-15
NO330640B1 (en) 2011-05-30
CY1107980T1 (en) 2013-09-04
ECSP055870A (en) 2005-09-20
NO20052777L (en) 2005-07-13

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