ECSP034929A - CDK INHIBITING PYRIMIDINS, THEIR PREPARATION AND USE AS A MEDICINAL PRODUCT - Google Patents

CDK INHIBITING PYRIMIDINS, THEIR PREPARATION AND USE AS A MEDICINAL PRODUCT

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Publication number
ECSP034929A
ECSP034929A EC2003004929A ECSP034929A ECSP034929A EC SP034929 A ECSP034929 A EC SP034929A EC 2003004929 A EC2003004929 A EC 2003004929A EC SP034929 A ECSP034929 A EC SP034929A EC SP034929 A ECSP034929 A EC SP034929A
Authority
EC
Ecuador
Prior art keywords
pyrimidins
preparation
medicinal product
cdk inhibiting
cdk
Prior art date
Application number
EC2003004929A
Other languages
Spanish (es)
Inventor
Gerhard Siemeister
Christoph Huwe
Martina Schafer
Rolf Jautelat
Olaf Prien
Thomas Brumby
Ulrich Lucking
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ECSP034929A publication Critical patent/ECSP034929A/en

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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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Abstract

La presente invención se refiere a derivados de pirimidina de la fórmula general (1), donde R1, R2, X, A y B tienen los significados mencionados en la memoria descriptiva, para uso como inhibidores de quinazas dependientes de ciclina. La invención además se relaciona a su producción, así como a sus usos como medicamento para el tratamiento de diferentes enfermedades.The present invention relates to pyrimidine derivatives of the general formula (1), wherein R1, R2, X, A and B have the meanings mentioned in the specification, for use as inhibitors of cyclin-dependent quinases. The invention also relates to its production, as well as its uses as a medicament for the treatment of different diseases.

EC2003004929A 2001-05-29 2003-12-29 CDK INHIBITING PYRIMIDINS, THEIR PREPARATION AND USE AS A MEDICINAL PRODUCT ECSP034929A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10127581A DE10127581A1 (en) 2001-05-29 2001-05-29 New 2-anilino-pyrimidine derivatives, are potent cyclin dependent kinase inhibitors, useful e.g. for treating cancer, autoimmune, cardiovascular or neurodegenerative diseases or viral infections

Publications (1)

Publication Number Publication Date
ECSP034929A true ECSP034929A (en) 2004-09-28

Family

ID=7687462

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004929A ECSP034929A (en) 2001-05-29 2003-12-29 CDK INHIBITING PYRIMIDINS, THEIR PREPARATION AND USE AS A MEDICINAL PRODUCT

Country Status (4)

Country Link
DE (1) DE10127581A1 (en)
EC (1) ECSP034929A (en)
UA (1) UA78208C2 (en)
ZA (1) ZA200309824B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE50212771D1 (en) 2001-10-17 2008-10-23 Boehringer Ingelheim Pharma PYRIMIDIN DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THEIR PREPARATION
PL1799230T3 (en) 2004-08-27 2013-05-31 Cyclacel Ltd Purine and pyrimidine cdk inhibitors and their use for the treatment of autoimmune diseases
US8211401B2 (en) * 2008-12-05 2012-07-03 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting PSMA
DE102020113792A1 (en) 2020-05-22 2021-11-25 Daimler Ag Method and transport system for disposing of waste

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9523675D0 (en) * 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
GB9705361D0 (en) * 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9828511D0 (en) * 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds

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ZA200309824B (en) 2006-05-31
DE10127581A1 (en) 2003-01-02
UA78208C2 (en) 2007-03-15

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