ECSP034606A - Uso de antiprogestinas para la induccion de apoptosis en una celula - Google Patents
Uso de antiprogestinas para la induccion de apoptosis en una celulaInfo
- Publication number
- ECSP034606A ECSP034606A EC2003004606A ECSP034606A ECSP034606A EC SP034606 A ECSP034606 A EC SP034606A EC 2003004606 A EC2003004606 A EC 2003004606A EC SP034606 A ECSP034606 A EC SP034606A EC SP034606 A ECSP034606 A EC SP034606A
- Authority
- EC
- Ecuador
- Prior art keywords
- cell
- antiprogestin
- apoptosis
- antiprogestines
- induction
- Prior art date
Links
- 230000006882 induction of apoptosis Effects 0.000 title 1
- 230000000708 anti-progestin effect Effects 0.000 abstract 4
- 239000003418 antiprogestin Substances 0.000 abstract 4
- -1 4-acetylphenyl Chemical group 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- IZGGUFACPUOLFX-RYRKJORJSA-N C1CCC=C2CC[C@@H]([C@H]3[C@@](C)(C(CC3)=O)CC3)C3=C21 Chemical compound C1CCC=C2CC[C@@H]([C@H]3[C@@](C)(C(CC3)=O)CC3)C3=C21 IZGGUFACPUOLFX-RYRKJORJSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000018199 S phase Effects 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con métodos y usos para inducir apoptosis en una célula, en particular una célula de cáncer de mama, mediante la administración de antiprogestinas, en particular la antiprogestina 11b-(4-acetilfenil) -17b-hidroxi-17a-(1, 1 2, 2, 2-pentafluoroetil) estra-4, 9- dien-ona o un derivado o análogo de la misma aceptable para uso farmacéutico. La invención se relaciona además con un tratamiento para el cáncer, donde un indicador de alto riesgo es una cantidad incrementada de células tumorales en la fase S del ciclo celular, tratamiento que comprende una antiprogestina, en particular la antiprogestina 11b-(4-acetilfenil)-17b-hidroxi-17a-(1, 1 2, 2,2- pentafluoroetil)-extra-4, 9-dien-3-ona o un derivado o análogo de la misma aceptable para uso farmacéutico
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00250342 | 2000-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034606A true ECSP034606A (es) | 2003-06-25 |
Family
ID=32049951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2003004606A ECSP034606A (es) | 2000-10-18 | 2003-05-14 | Uso de antiprogestinas para la induccion de apoptosis en una celula |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040072811A1 (es) |
| AR (1) | AR030998A1 (es) |
| EC (1) | ECSP034606A (es) |
| PE (1) | PE20020511A1 (es) |
| RS (1) | RS50350B (es) |
| UY (1) | UY26966A1 (es) |
| ZA (1) | ZA200303790B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2683517A1 (en) * | 2007-04-23 | 2008-10-30 | Bayer Schering Pharma Aktiengesellschaft | Combination of progesterone-receptor antagonist together with a lutein-hormone-releasing hormone agonist and antagonist for use in brca mediated diseases |
| AU2012318618B2 (en) * | 2011-10-04 | 2017-01-12 | Invivis Pharmaceuticals Inc. | Methods and systems for identifying and treating anti-progestin sensitive tumors |
| RU2017112748A (ru) | 2014-11-17 | 2018-12-19 | Арно Терапьютикс, Инк. | Композиции онапристона пролонгированного действия и способы |
| AU2016326657B2 (en) | 2015-09-25 | 2019-10-24 | Context Biopharma, Inc. | Methods of making onapristone intermediates |
| HK1255104A1 (zh) | 2015-12-15 | 2019-08-02 | Context Biopharma Inc. | 无定形的奥那司酮组合物及其制备方法 |
| WO2018102369A1 (en) | 2016-11-30 | 2018-06-07 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19706061A1 (de) * | 1997-02-07 | 1998-08-13 | Schering Ag | Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette |
-
2001
- 2001-10-12 UY UY26966A patent/UY26966A1/es not_active Application Discontinuation
- 2001-10-17 RS YUP-299/03A patent/RS50350B/sr unknown
- 2001-10-17 PE PE2001001032A patent/PE20020511A1/es not_active Application Discontinuation
- 2001-10-17 US US10/399,319 patent/US20040072811A1/en not_active Abandoned
- 2001-10-17 AR ARP010104868A patent/AR030998A1/es unknown
-
2003
- 2003-05-14 EC EC2003004606A patent/ECSP034606A/es unknown
- 2003-05-15 ZA ZA200303790A patent/ZA200303790B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR030998A1 (es) | 2003-09-03 |
| RS50350B (sr) | 2009-11-10 |
| US20040072811A1 (en) | 2004-04-15 |
| PE20020511A1 (es) | 2002-06-15 |
| YU29903A (sh) | 2006-08-17 |
| ZA200303790B (en) | 2004-08-16 |
| UY26966A1 (es) | 2002-06-20 |
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