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Se proporciona un compuesto que inhibe a P2 que tiene la fórmula (gráfico), en donde R1, R2, R3, R4, X-X y (gráfico), son como se describen en la presente. También se proporciona un método para tratar la diabetes y enfermedades relacionadas, especialmenrte diabets tipo II, que emplean estos inhibidores de aP2 o una combinación de este inhibidor de aP2 y otro agente antidiabético tal como metformina, gliburido, troglitazona y/o insulina.A P2-inhibiting compound is provided having the formula (graph), wherein R1, R2, R3, R4, X-X and (graph), are as described herein. Also provided is a method of treating diabetes and related diseases, especially type II diabets, that employ these aP2 inhibitors or a combination of this aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone, and / or insulin.
DERIVATIVES OF 1-PIRAZOL-3-ILETIL-4-INDOL-3-ILPIPERIDINA, A PROCEDURE FOR PREPARING THEM, MEDICINES AND PHARMACEUTICAL PREPARATIONS THAT CONTAIN THEM, A PROCEDURE FOR PREPARING THE PHARMACEUTICAL PREPARATIONS AND USE OF THE SAME MEDICINAL PREPARATIONS FOR THE PREPARATIONS