EA202190596A2 - PROVISION OF A PHARMACOKINETIC DRUG DOSAGE SCHEME - Google Patents

PROVISION OF A PHARMACOKINETIC DRUG DOSAGE SCHEME

Info

Publication number
EA202190596A2
EA202190596A2 EA202190596A EA202190596A EA202190596A2 EA 202190596 A2 EA202190596 A2 EA 202190596A2 EA 202190596 A EA202190596 A EA 202190596A EA 202190596 A EA202190596 A EA 202190596A EA 202190596 A2 EA202190596 A2 EA 202190596A2
Authority
EA
Eurasian Patent Office
Prior art keywords
dosing
pattern
plasma protein
provision
therapeutic plasma
Prior art date
Application number
EA202190596A
Other languages
Russian (ru)
Other versions
EA202190596A3 (en
Inventor
Александра Лев-Базелли
Джералд Дики Споттс
МиунгШин Ох
Original Assignee
Баксалта Инкорпорейтед
Баксалта Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Баксалта Инкорпорейтед, Баксалта Гмбх filed Critical Баксалта Инкорпорейтед
Publication of EA202190596A2 publication Critical patent/EA202190596A2/en
Publication of EA202190596A3 publication Critical patent/EA202190596A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
    • B23P17/00—Metal-working operations, not covered by a single other subclass or another group in this subclass
    • B23P17/04—Metal-working operations, not covered by a single other subclass or another group in this subclass characterised by the nature of the material involved or the kind of product independently of its shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Система и способ предоставления схемы дозирования терапевтического белка плазмы включают определение фармакокинетического профиля пациента с использованием байесовской модели фармакокинетических профилей пациентов, у которых брали образцы. Примерные система и способ также включают определение первой схемы дозирования для первого заданного интервала дозирования, которая содержит (i) первую дозу и (ii) первый уровень терапевтического белка плазмы у пациента в течение периода времени, на основании, по меньшей мере, фармакокинетического профиля и определение второй схемы дозирования для второго заданного интервала дозирования, которая содержит (i) вторую дозу и (ii) второй уровень терапевтического белка плазмы у пациента в течение периода времени, на основании, по меньшей мере, фармакокинетического профиля. Примерные система и способ дополнительно включают отображение первой схемы дозирования и второй схемы дозирования на клиентском устройстве так, что первую схему дозирования отображают в сочетании со второй схемой дозирования.The system and method for providing a dosage regimen for a therapeutic plasma protein comprises determining a pharmacokinetic profile of a patient using a Bayesian model of pharmacokinetic profiles from sampled patients. The exemplary system and method also includes determining a first dosing regimen for a first predetermined dosing interval that comprises (i) a first dose and (ii) a first therapeutic plasma protein level in a patient over a period of time based on at least a pharmacokinetic profile and determining a second dosing regimen for a second predetermined dosing interval, which comprises (i) a second dose and (ii) a second level of therapeutic plasma protein in a patient over a period of time based at least on the pharmacokinetic profile. The exemplary system and method further includes displaying the first dosing pattern and the second dosing pattern on the client device such that the first dosing pattern is displayed in conjunction with the second dosing pattern.

EA202190596A 2013-09-23 2014-06-20 PROVISION OF A PHARMACOKINETIC DRUG DOSAGE SCHEME EA202190596A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361881214P 2013-09-23 2013-09-23

Publications (2)

Publication Number Publication Date
EA202190596A2 true EA202190596A2 (en) 2021-06-30
EA202190596A3 EA202190596A3 (en) 2021-10-29

Family

ID=76807398

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190596A EA202190596A3 (en) 2013-09-23 2014-06-20 PROVISION OF A PHARMACOKINETIC DRUG DOSAGE SCHEME

Country Status (1)

Country Link
EA (1) EA202190596A3 (en)

Also Published As

Publication number Publication date
EA202190596A3 (en) 2021-10-29

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