EA202091384A1 - METHOD FOR PRODUCING GAMMA-BUTYROBETAINE AND ITS HYDROCHLORIDE - Google Patents

METHOD FOR PRODUCING GAMMA-BUTYROBETAINE AND ITS HYDROCHLORIDE

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Publication number
EA202091384A1
EA202091384A1 EA202091384A EA202091384A EA202091384A1 EA 202091384 A1 EA202091384 A1 EA 202091384A1 EA 202091384 A EA202091384 A EA 202091384A EA 202091384 A EA202091384 A EA 202091384A EA 202091384 A1 EA202091384 A1 EA 202091384A1
Authority
EA
Eurasian Patent Office
Prior art keywords
butyrobetaine
gamma
salt
hydrochloride
producing
Prior art date
Application number
EA202091384A
Other languages
Russian (ru)
Inventor
Андрей Станиславович Радилов
Виктор Анатольевич Кузнецов
Денис Викторович Криворотов
Андрей Александрович Щипалкин
Николай Николаевич Мартинович
Original Assignee
Федеральное Государственное Унитарное Предприятие "Научно-Исследовательский Институт Гигиены, Профпатологии И Экологии Человека"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное Государственное Унитарное Предприятие "Научно-Исследовательский Институт Гигиены, Профпатологии И Экологии Человека" filed Critical Федеральное Государственное Унитарное Предприятие "Научно-Исследовательский Институт Гигиены, Профпатологии И Экологии Человека"
Publication of EA202091384A1 publication Critical patent/EA202091384A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к способу получения гамма-бутиробетаина из гамма-аминомасляной кислоты и диметилсульфата, в котором процесс осуществляют при температуре 0-5°C, в присутствии подходящего щелочного агента и диоксида углерода, с образованием соли гамма-бутиробетаина и монометилового эфира серной кислоты, дальнейшей экстракции указанной соли в подходящем растворителе и возможностью ее последующего превращения в цвиттер-ион (внутреннюю соль) гамма-бутиробетаина, либо в гидрохлорид гамма-бутиробетаина. Технический результат - разработан новый способ получения гамма-бутиробетаина высокой частоты и выходом, который находит свое применение для производства фармацевтических, пищевых и косметических средств и субстанций.The invention relates to a method for producing gamma-butyrobetaine from gamma-aminobutyric acid and dimethyl sulfate, in which the process is carried out at a temperature of 0-5 ° C, in the presence of a suitable alkaline agent and carbon dioxide, with the formation of a salt of gamma-butyrobetaine and monomethyl sulfuric acid ester, further extraction of said salt in a suitable solvent and the possibility of its subsequent conversion into a zwitterion (internal salt) of gamma-butyrobetaine or into gamma-butyrobetaine hydrochloride. EFFECT: developed a new method for producing gamma-butyrobetaine of high frequency and yield, which is used for the production of pharmaceutical, food and cosmetic products and substances.

EA202091384A 2019-07-04 2020-07-03 METHOD FOR PRODUCING GAMMA-BUTYROBETAINE AND ITS HYDROCHLORIDE EA202091384A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2019120885A RU2720985C1 (en) 2019-07-04 2019-07-04 Method of producing gamma-butirobethaine and hydrochloride thereof

Publications (1)

Publication Number Publication Date
EA202091384A1 true EA202091384A1 (en) 2021-01-29

Family

ID=70735233

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091384A EA202091384A1 (en) 2019-07-04 2020-07-03 METHOD FOR PRODUCING GAMMA-BUTYROBETAINE AND ITS HYDROCHLORIDE

Country Status (2)

Country Link
EA (1) EA202091384A1 (en)
RU (1) RU2720985C1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0291049A (en) * 1988-09-21 1990-03-30 Lonza Ag Production of gamma-butyrobetaine
LV13705B (en) * 2006-11-06 2008-07-20 Ivars Kalvins Process for producing high purity intermolecular salt of 3-carboxy-n,n,n-trimethyl-propane-1-amine hydroxide
CN101538214A (en) * 2009-04-24 2009-09-23 潍坊祥维斯化学品有限公司 Method for preparing gamma-butyrobetaine and hydrochloride thereof

Also Published As

Publication number Publication date
RU2720985C1 (en) 2020-05-15

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