EA202090769A1 - Пищевая, косметическая и фармацевтическая композиция с иммуномодулирующим и протективным антивирусным эффектом - Google Patents
Пищевая, косметическая и фармацевтическая композиция с иммуномодулирующим и протективным антивирусным эффектомInfo
- Publication number
- EA202090769A1 EA202090769A1 EA202090769A EA202090769A EA202090769A1 EA 202090769 A1 EA202090769 A1 EA 202090769A1 EA 202090769 A EA202090769 A EA 202090769A EA 202090769 A EA202090769 A EA 202090769A EA 202090769 A1 EA202090769 A1 EA 202090769A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- food
- cosmetic
- immunomodulating
- pharmaceutical composition
- probiotics
- Prior art date
Links
- 235000013305 food Nutrition 0.000 title abstract 5
- 239000002537 cosmetic Substances 0.000 title abstract 4
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 230000000840 anti-viral effect Effects 0.000 title abstract 3
- 230000001681 protective effect Effects 0.000 title abstract 3
- 239000006041 probiotic Substances 0.000 abstract 5
- 235000018291 probiotics Nutrition 0.000 abstract 5
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 2
- 238000012986 modification Methods 0.000 abstract 2
- 230000000529 probiotic effect Effects 0.000 abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 abstract 1
- 229930192334 Auxin Natural products 0.000 abstract 1
- 241000193749 Bacillus coagulans Species 0.000 abstract 1
- 241000711573 Coronaviridae Species 0.000 abstract 1
- 229930191978 Gibberellin Natural products 0.000 abstract 1
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 208000029462 Immunodeficiency disease Diseases 0.000 abstract 1
- 206010062106 Respiratory tract infection viral Diseases 0.000 abstract 1
- 241000702670 Rotavirus Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000002363 auxin Substances 0.000 abstract 1
- 241000385736 bacterium B Species 0.000 abstract 1
- IZTUINVRJSCOIR-UHFFFAOYSA-N benzylisoquinoline Chemical group N=1C=CC2=CC=CC=C2C=1CC1=CC=CC=C1 IZTUINVRJSCOIR-UHFFFAOYSA-N 0.000 abstract 1
- 229960004203 carnitine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- IXORZMNAPKEEDV-UHFFFAOYSA-N gibberellic acid GA3 Natural products OC(=O)C1C2(C3)CC(=C)C3(O)CCC2C2(C=CC3O)C1C3(C)C(=O)O2 IXORZMNAPKEEDV-UHFFFAOYSA-N 0.000 abstract 1
- 239000003448 gibberellin Substances 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- 150000002338 glycosides Chemical class 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000007813 immunodeficiency Effects 0.000 abstract 1
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 239000000419 plant extract Substances 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
Classifications
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Abstract
Отрасль применения: изобретение относится к биотехнологии, может быть использовано в пищевой промышленности, медицине и косметологии при профилактике и/или лечении заболеваний, связанных с иммунодефицитами и респираторными вирусными инфекциями. Суть изобретения: в основу изобретения поставлена задача разработать пищевую, косметическую и фармацевтическую композицию с мощным иммуномодулирующим и протективным антивирусным эффектом. Поставленная задача решается путем получения пищевой, косметической и фармацевтической композиции, включающей смесь пробиотиков с иммуномодулирующим эффектом, отличающейся тем, что среди пробиотиков содержит в том числе модифицированные споры сапрофитной пробиотической бактерии B. coagulans, поверхность которых ковалентно химически модифицирована с разными степенями модификации, а композиция также дополнительно содержит соединения группы бензилизохинолина или сырье, их содержащее, растительные экстракты с гликозидами, а также содержит как минимум два из следующих компонентов: гиббереллин, парааминобензойную кислоту; карнитин; ауксин или его производное. При этом степени модификации белково-полисахаридных антигенов спор сапрофитной пробиотической бактерии B. coagulans находятся в диапазоне от 0,1 до 15% в пересчете на белок. Предлагаемая пищевая, косметическая и фармацевтическая композиция с иммуномодулирующим и протективным антивирусным эффектом дополнительно обладает способностью полностью предотвращать инфицирование рядом вирусов, в том числе гриппа, ротавирусом и коронавирусом, а также стимулировать иммунитет сильнее, чем отдельно взятые пробиотики.
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PCT/RU2018/000292 WO2019212379A1 (ru) | 2018-05-04 | 2018-05-04 | Пищевая, косметическая и фармацевтическая композиция с иммуномодулирующим и протективным антивирусным эффектом |
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WO2020063531A1 (zh) * | 2018-09-30 | 2020-04-02 | 内蒙古伊利实业集团股份有限公司 | 副干酪乳杆菌et-22及其用途 |
WO2021167609A1 (en) * | 2020-02-18 | 2021-08-26 | Xia Xin Rui | Method for treating and preventing coronavirus (covid-19) infection by direct pulmonary administration of a selected microorganism |
CN117202785A (zh) * | 2021-03-30 | 2023-12-08 | 维沃保护公司 | 用于预防人类病原体在蔬菜上形成和生长的细菌菌株 |
KR20240037256A (ko) * | 2021-06-30 | 2024-03-21 | 에이비 마우리 (유케이) 리미티드 | 생리학적으로 허용되는 효모 조성물 및 이의 용도 |
WO2023046844A1 (en) * | 2021-09-27 | 2023-03-30 | Biocodex | Pharmaceutical compositions useful for the prevention or treatment of viral infections |
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US5580857A (en) * | 1989-12-12 | 1996-12-03 | Oden; Per | Use of gibberellins for the treatment of prostatitis |
US5455033A (en) * | 1993-05-21 | 1995-10-03 | Degree/Silverman M.D. Inc. | Medicinal composition for treatment of inflammation |
US6645506B1 (en) * | 1997-04-18 | 2003-11-11 | Ganeden Biotech, Inc. | Topical compositions containing extracellular products of Pseudomonas lindbergii and Emu oil |
FR2772609B1 (fr) * | 1997-12-19 | 2004-05-07 | Oreal | Utilisation d'au moins une auxine dans une composition cosmetique |
IT1317911B1 (it) * | 2000-09-28 | 2003-07-15 | Idi Irccs | Formulazione cosmetica. |
US20060263344A1 (en) * | 2003-04-02 | 2006-11-23 | Mitchell Skop | Novel probiotic compositions and methods of using the same |
US20050032674A1 (en) * | 2003-07-03 | 2005-02-10 | Kelly Ciaran P. | SAIF, an anti-inflammatory factor, and methods of use thereof |
CN101543629B (zh) * | 2008-03-27 | 2011-11-16 | 北京荣昌药物研究院有限公司 | 盐酸罂粟碱作为透皮吸收促进剂的应用 |
WO2009149553A1 (en) * | 2008-06-12 | 2009-12-17 | Universite Laval | Modified protein excipient for delayed-release tablet |
WO2013130829A1 (en) * | 2012-02-28 | 2013-09-06 | Ganeden Biotech, Inc. | Cosmetic compositions |
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