EA201992489A3 - Хинолиноновые производные пиридин-2(1h)-она как ингибиторы мутантной изоцитратдегидрогеназы - Google Patents

Хинолиноновые производные пиридин-2(1h)-она как ингибиторы мутантной изоцитратдегидрогеназы

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Publication number
EA201992489A3
EA201992489A3 EA201992489A EA201992489A EA201992489A3 EA 201992489 A3 EA201992489 A3 EA 201992489A3 EA 201992489 A EA201992489 A EA 201992489A EA 201992489 A EA201992489 A EA 201992489A EA 201992489 A3 EA201992489 A3 EA 201992489A3
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
pyridine
isocitrate dehydrogenase
mutant isocitrate
quinolinone derivatives
Prior art date
Application number
EA201992489A
Other languages
English (en)
Other versions
EA038574B1 (ru
EA201992489A2 (ru
Inventor
Сьюзан Эшвелл
Анн-Мари Кэмпбелл
Джастин Эндрю Каравелла
Р. Брюс Дайболд
Анна Эрикссон
Гари Густафсон
мл. Дэвид Р. Лансия
Цзянь ЛИНЬ
Вэй Лу
Чжунго Ван
Original Assignee
Форма Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Форма Терапьютикс, Инк. filed Critical Форма Терапьютикс, Инк.
Publication of EA201992489A2 publication Critical patent/EA201992489A2/ru
Publication of EA201992489A3 publication Critical patent/EA201992489A3/ru
Publication of EA038574B1 publication Critical patent/EA038574B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение относится к ингибиторам белков мутантной изоцитратдегидрогеназы (mt-ИДГ), обладающим неоморфной активностью, пригодным для лечения нарушений клеточной пролиферации и различных видов рака, имеющим формулугде A, U, W, W, W, R-Rи Rописаны в данном документе.
EA201992489A 2015-04-21 2015-09-18 Хинолиноновые производные пиридин-2(1h)-она и фармацевтические композиции на их основе EA038574B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562150812P 2015-04-21 2015-04-21

Publications (3)

Publication Number Publication Date
EA201992489A2 EA201992489A2 (ru) 2020-02-28
EA201992489A3 true EA201992489A3 (ru) 2020-05-31
EA038574B1 EA038574B1 (ru) 2021-09-16

Family

ID=69636699

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992489A EA038574B1 (ru) 2015-04-21 2015-09-18 Хинолиноновые производные пиридин-2(1h)-она и фармацевтические композиции на их основе

Country Status (1)

Country Link
EA (1) EA038574B1 (ru)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99731A0 (en) * 1990-10-18 1992-08-18 Merck & Co Inc Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them
US20030105124A1 (en) * 2000-04-27 2003-06-05 Susan Beth Sobolov-Jaynes Substituted benzolactam compounds
JP2005532368A (ja) * 2002-06-12 2005-10-27 アボット・ラボラトリーズ メラニン濃縮ホルモン受容体の拮抗薬
CN102558049B (zh) * 2010-12-17 2015-02-04 中国科学院上海药物研究所 一类双香豆素类化合物及其制备方法和用途
SI2800743T1 (en) * 2012-01-06 2018-08-31 Agios Pharmaceuticals, Inc. Therapeutically active compounds and methods for their use

Also Published As

Publication number Publication date
EA038574B1 (ru) 2021-09-16
EA201992489A2 (ru) 2020-02-28

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM