EA201992312A1 - Биспецифические анти-cd37-антитела, моноклональные анти-cd37-антитела и способы их применения - Google Patents

Биспецифические анти-cd37-антитела, моноклональные анти-cd37-антитела и способы их применения

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Publication number
EA201992312A1
EA201992312A1 EA201992312A EA201992312A EA201992312A1 EA 201992312 A1 EA201992312 A1 EA 201992312A1 EA 201992312 A EA201992312 A EA 201992312A EA 201992312 A EA201992312 A EA 201992312A EA 201992312 A1 EA201992312 A1 EA 201992312A1
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Eurasian Patent Office
Prior art keywords
antibodies
methods
application
bispecific antibody
antibody molecules
Prior art date
Application number
EA201992312A
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English (en)
Inventor
Симоне Остинди
Франк Бёрскенс
Эстер Брей
Эдвард Ван Ден Бринк
Андреас Холленстейн
Марейе Овердейк
Маргарет Линдорфер
Рональд Тейлор
Паул Паррен
Хилма Ван Дер Хорст
Мартина И.Д. Шамюло
Тюна Мютис
Original Assignee
Генмаб Холдинг Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Генмаб Холдинг Б.В. filed Critical Генмаб Холдинг Б.В.
Priority claimed from PCT/EP2018/058479 external-priority patent/WO2018178396A1/en
Publication of EA201992312A1 publication Critical patent/EA201992312A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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Abstract

Молекулы биспецифического антитела, специфичного к CD37, связывающиеся с различными эпитопами человеческого антигена CD37, где молекулы биспецифического антитела имеют усиленные Fc-Fc взаимодействия при связывании с CD37 на поверхности клетки. Изобретение также относится к моноклональным исходным антителам, из которых получают первую или вторую связывающие области молекул биспецифического антитела. Изобретение также относится к фармацевтическим композициям, содержащим эти молекулы, и к лечению рака и других заболеваний с использованием этих композиций.
EA201992312A 2018-03-27 2018-04-03 Биспецифические анти-cd37-антитела, моноклональные анти-cd37-антитела и способы их применения EA201992312A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2018057836 2018-03-27
PCT/EP2018/058479 WO2018178396A1 (en) 2017-03-31 2018-04-03 Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
EA201992312A1 true EA201992312A1 (ru) 2020-03-06

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EA201992312A EA201992312A1 (ru) 2018-03-27 2018-04-03 Биспецифические анти-cd37-антитела, моноклональные анти-cd37-антитела и способы их применения

Country Status (1)

Country Link
EA (1) EA201992312A1 (ru)

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