EA201991944A1 - BACILLUS SUBTILIS STRAINS IMPROVING ANIMAL PRODUCTIVITY INDICATORS - Google Patents

BACILLUS SUBTILIS STRAINS IMPROVING ANIMAL PRODUCTIVITY INDICATORS

Info

Publication number
EA201991944A1
EA201991944A1 EA201991944A EA201991944A EA201991944A1 EA 201991944 A1 EA201991944 A1 EA 201991944A1 EA 201991944 A EA201991944 A EA 201991944A EA 201991944 A EA201991944 A EA 201991944A EA 201991944 A1 EA201991944 A1 EA 201991944A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bacillus subtilis
strain
reduced
animal
subtilis strain
Prior art date
Application number
EA201991944A
Other languages
Russian (ru)
Inventor
Дорте Сандванг
Тина Стюрисхаве
Original Assignee
Кхр. Хансен А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кхр. Хансен А/С filed Critical Кхр. Хансен А/С
Priority claimed from PCT/EP2018/056442 external-priority patent/WO2018167171A1/en
Publication of EA201991944A1 publication Critical patent/EA201991944A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Fodder In General (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

В настоящем изобретении предложен штамм Bacillus subtilis, выбранный из группы, состоящей из а) штамма, депонированного как DSM32324, б) штамма, депонированного как DSM32325, и в) мутантного штамма по (а) или (б), обладающий чувствительностью к ампициллину, ванкомицину, гентамицину, канамицину, стрептомицину, эритромицину, клиндамицину, тетрациклину и хлорамфениколу и обладающий ингибирующей активностью в отношении Е. coli и Clostridium perfringens. Кроме того, изобретение относится к композициям Bacillus, содержащим по меньшей мере один штамм Bacillus subtilis по изобретению, предпочтительно штамм Bacillus subtilis DSM32324 и/или штамм Bacillus subtilis DSM32325, в качестве пробиотика (DFM), премикса, кормовой добавки для животных или корма для животных. В изобретении предложен способ улучшения одного или более показателей продуктивности животного, выбранных из группы, состоящей из 1) увеличенного прироста массы (WG), 2) пониженного коэффициента кормоотдачи (FCR), 3) пониженной балльной оценки поражения от некротического энтерита, 4) пониженной частоты некротического энтерита, 5) пониженной смертности от некротического энтерита, 6) повышенного Европейского фактора эффективности производства (EPEF) и 7) пониженной смертности, путем кормления животного штаммом или композицией по настоящему изобретению.The present invention provides a Bacillus subtilis strain selected from the group consisting of a) a strain deposited as DSM32324, b) a strain deposited as DSM32325, and c) a mutant strain according to (a) or (b) having sensitivity to ampicillin, vancomycin , gentamycin, kanamycin, streptomycin, erythromycin, clindamycin, tetracycline and chloramphenicol, and has inhibitory activity against E. coli and Clostridium perfringens. In addition, the invention relates to Bacillus compositions containing at least one Bacillus subtilis strain according to the invention, preferably Bacillus subtilis strain DSM32324 and / or Bacillus subtilis strain DSM32325, as probiotic (DFM), premix, animal feed additive or animal feed ... The invention provides a method for improving one or more performance indicators of an animal selected from the group consisting of 1) increased weight gain (WG), 2) reduced feed-return ratio (FCR), 3) reduced scores for necrotic enteritis damage, 4) reduced frequency necrotizing enteritis, 5) reduced mortality from necrotizing enteritis, 6) increased European production efficiency factor (EPEF), and 7) reduced mortality, by feeding the animal with the strain or composition of the present invention.

EA201991944A 2018-02-02 2018-03-14 BACILLUS SUBTILIS STRAINS IMPROVING ANIMAL PRODUCTIVITY INDICATORS EA201991944A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18154862 2018-02-02
PCT/EP2018/056442 WO2018167171A1 (en) 2017-03-14 2018-03-14 Bacillus subtilis strains improving animal performance parameters

Publications (1)

Publication Number Publication Date
EA201991944A1 true EA201991944A1 (en) 2020-02-21

Family

ID=61157069

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991944A EA201991944A1 (en) 2018-02-02 2018-03-14 BACILLUS SUBTILIS STRAINS IMPROVING ANIMAL PRODUCTIVITY INDICATORS

Country Status (1)

Country Link
EA (1) EA201991944A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117461725A (en) * 2023-12-13 2024-01-30 广东省农业科学院动物科学研究所 Composition, feed and application for reducing emission of poultry odor substances

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117461725A (en) * 2023-12-13 2024-01-30 广东省农业科学院动物科学研究所 Composition, feed and application for reducing emission of poultry odor substances

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