EA201991889A1 - Ассоциат n-ацетилцистеина и колистина для применения при бактериальных инфекциях - Google Patents
Ассоциат n-ацетилцистеина и колистина для применения при бактериальных инфекцияхInfo
- Publication number
- EA201991889A1 EA201991889A1 EA201991889A EA201991889A EA201991889A1 EA 201991889 A1 EA201991889 A1 EA 201991889A1 EA 201991889 A EA201991889 A EA 201991889A EA 201991889 A EA201991889 A EA 201991889A EA 201991889 A1 EA201991889 A1 EA 201991889A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- associate
- colistine
- acetylcysteine
- bacterial infections
- bacterial infection
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title abstract 3
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 3
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title 1
- 229960004308 acetylcysteine Drugs 0.000 title 1
- YKQOSKADJPQZHB-RGYSVOEGSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(6r,9s,12r,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydr Chemical compound CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)C([C@@H](C)O)NC(=O)[C@@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-RGYSVOEGSA-N 0.000 title 1
- 241000588626 Acinetobacter baumannii Species 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000014085 Chronic respiratory disease Diseases 0.000 abstract 1
- 108010078777 Colistin Proteins 0.000 abstract 1
- 241000122973 Stenotrophomonas maltophilia Species 0.000 abstract 1
- 201000009267 bronchiectasis Diseases 0.000 abstract 1
- 229960003346 colistin Drugs 0.000 abstract 1
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 abstract 1
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Настоящее изобретение относится к синергическому фармакологическому ассоциату NAC и колистина для применения в лечении бактериальной инфекции, вызванной одним или более патогенами, выбранными из штаммов S. maltophilia и A. baumannii, в частности бактериальной инфекции, связанной с заболеванием дыхательных путей, таким как хроническое заболевание дыхательных путей, включая CF, немуковисцидозный бронхоэктаз и COPD.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17158241.4A EP3366284A1 (en) | 2017-02-27 | 2017-02-27 | Association of n-acetylcysteine and colistin for use in bacterial infections |
| PCT/EP2018/054611 WO2018154091A1 (en) | 2017-02-27 | 2018-02-26 | Association of n-acetylcysteine and colistin for use in bacterial infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201991889A1 true EA201991889A1 (ru) | 2020-01-09 |
Family
ID=58191354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201991889A EA201991889A1 (ru) | 2017-02-27 | 2018-02-26 | Ассоциат n-ацетилцистеина и колистина для применения при бактериальных инфекциях |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11382948B2 (ru) |
| EP (2) | EP3366284A1 (ru) |
| JP (1) | JP7241687B2 (ru) |
| CN (1) | CN110352053B (ru) |
| AU (1) | AU2018223985B2 (ru) |
| BR (1) | BR112019017113A2 (ru) |
| CA (1) | CA3053441A1 (ru) |
| CO (1) | CO2019009216A2 (ru) |
| EA (1) | EA201991889A1 (ru) |
| WO (1) | WO2018154091A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000023665A1 (it) | 2020-10-07 | 2022-04-07 | Brenta S R L | Sistema di nanoparticelle per il veicolo e la somministrazione di principi attivi e relativo metodo di produzione, nonché attività di eradicazione di biofilm |
| EP4282410A1 (en) | 2022-05-27 | 2023-11-29 | Zambon S.p.A. | Association of colistin and n-acetalcysteine in the treatment of bacterial infections by p. aeruginosa in a mature biofilm phase of growth |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE202481T1 (de) * | 1996-11-15 | 2001-07-15 | Pathogenesis Corp | Reines, biologisch aktives colistin, seine bestandteile und eine colistin-zubereitung zur behandlung von entzündungen der atemwege |
| ITMI20021881A1 (it) * | 2002-09-04 | 2004-03-05 | Zambon Spa | Composizioni farmaceutiche per il trattamento di infezioni da patogeni dell'apparato urinario. |
| GB201021186D0 (en) * | 2010-12-14 | 2011-01-26 | Novabiotics Ltd | Composition |
-
2017
- 2017-02-27 EP EP17158241.4A patent/EP3366284A1/en not_active Withdrawn
-
2018
- 2018-02-26 BR BR112019017113A patent/BR112019017113A2/pt active Search and Examination
- 2018-02-26 WO PCT/EP2018/054611 patent/WO2018154091A1/en active Application Filing
- 2018-02-26 CA CA3053441A patent/CA3053441A1/en active Pending
- 2018-02-26 EA EA201991889A patent/EA201991889A1/ru unknown
- 2018-02-26 AU AU2018223985A patent/AU2018223985B2/en active Active
- 2018-02-26 US US16/487,227 patent/US11382948B2/en active Active
- 2018-02-26 EP EP18707039.6A patent/EP3585372A1/en active Pending
- 2018-02-26 JP JP2019545362A patent/JP7241687B2/ja active Active
- 2018-02-26 CN CN201880012765.3A patent/CN110352053B/zh active Active
-
2019
- 2019-08-27 CO CONC2019/0009216A patent/CO2019009216A2/es unknown
-
2022
- 2022-05-20 US US17/664,232 patent/US20220370549A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019017113A2 (pt) | 2020-04-07 |
| EP3366284A1 (en) | 2018-08-29 |
| US11382948B2 (en) | 2022-07-12 |
| CA3053441A1 (en) | 2018-08-30 |
| CO2019009216A2 (es) | 2020-01-17 |
| AU2018223985A1 (en) | 2019-08-29 |
| US20210128678A1 (en) | 2021-05-06 |
| JP2020508318A (ja) | 2020-03-19 |
| WO2018154091A1 (en) | 2018-08-30 |
| CN110352053A (zh) | 2019-10-18 |
| AU2018223985B2 (en) | 2023-11-23 |
| EP3585372A1 (en) | 2020-01-01 |
| US20220370549A1 (en) | 2022-11-24 |
| JP7241687B2 (ja) | 2023-03-17 |
| CN110352053B (zh) | 2023-03-28 |
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