EA201991561A2 - FIBRONECTIN-BASED FRAME FRAME DOMAINS WHICH CONNECT TO MYOSTATIN - Google Patents

FIBRONECTIN-BASED FRAME FRAME DOMAINS WHICH CONNECT TO MYOSTATIN

Info

Publication number
EA201991561A2
EA201991561A2 EA201991561A EA201991561A EA201991561A2 EA 201991561 A2 EA201991561 A2 EA 201991561A2 EA 201991561 A EA201991561 A EA 201991561A EA 201991561 A EA201991561 A EA 201991561A EA 201991561 A2 EA201991561 A2 EA 201991561A2
Authority
EA
Eurasian Patent Office
Prior art keywords
proteins
frame
myostatin
fibronectin
present
Prior art date
Application number
EA201991561A
Other languages
Russian (ru)
Other versions
EA201991561A3 (en
Inventor
Шерон Клоад
Линда Энгл
Даса Липовсек
Малави Мадиредди
Джинджер Чао Ракестроу
Джоанна Свэйн
Вэньцзюнь Чжао
Хуэй Вэй
Аарон П. Ямниук
Видхашанкар Рамамурти
Александр Т. Кожич
Мартин Дж. Корбетт
Стенли Ричард Джр. Кристек
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201991561A2 publication Critical patent/EA201991561A2/en
Publication of EA201991561A3 publication Critical patent/EA201991561A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к основанным на фибронектине каркасным доменным белкам, которые связываются с миостатином. Настоящее изобретение также относится к применению этих белков в терапевтических применениях для лечения мышечной дистрофии, кахексии, саркопении, остеоартрита, остеопороза, сахарного диабета, ожирения, хронического обструктивного заболевания легких, хронического заболевания почек, сердечной недостаточности, инфаркта миокарда и фиброза. Настоящее изобретение дополнительно относится к клеткам, содержащим такие белки, полинуклеотидам, кодирующим такие белки или их фрагменты, а также векторам, содержащим полинуклеотиды, кодирующие белки.The present invention relates to fibronectin-based framework domain proteins that bind to myostatin. The present invention also relates to the use of these proteins in therapeutic applications for the treatment of muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes mellitus, obesity, chronic obstructive pulmonary disease, chronic kidney disease, heart failure, myocardial infarction and fibrosis. The present invention further relates to cells containing such proteins, polynucleotides encoding such proteins or fragments thereof, as well as vectors containing polynucleotides encoding proteins.

EA201991561A 2013-03-13 2013-09-12 FIBRONECTIN-BASED FRAME FRAME DOMAINS WHICH ARE CONNECTED TO MYOSTATIN EA201991561A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361780005P 2013-03-13 2013-03-13

Publications (2)

Publication Number Publication Date
EA201991561A2 true EA201991561A2 (en) 2020-03-31
EA201991561A3 EA201991561A3 (en) 2020-06-30

Family

ID=69942786

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991561A EA201991561A3 (en) 2013-03-13 2013-09-12 FIBRONECTIN-BASED FRAME FRAME DOMAINS WHICH ARE CONNECTED TO MYOSTATIN

Country Status (1)

Country Link
EA (1) EA201991561A3 (en)

Also Published As

Publication number Publication date
EA201991561A3 (en) 2020-06-30

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