EA201892734A1 - AZABENZIMIDAZOLE DERIVATIVES AS AN INTEGRATOR OF pI3K BETA INHIBITORS - Google Patents

AZABENZIMIDAZOLE DERIVATIVES AS AN INTEGRATOR OF pI3K BETA INHIBITORS

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Publication number
EA201892734A1
EA201892734A1 EA201892734A EA201892734A EA201892734A1 EA 201892734 A1 EA201892734 A1 EA 201892734A1 EA 201892734 A EA201892734 A EA 201892734A EA 201892734 A EA201892734 A EA 201892734A EA 201892734 A1 EA201892734 A1 EA 201892734A1
Authority
EA
Eurasian Patent Office
Prior art keywords
integrator
beta inhibitors
pi3k beta
azabenzimidazole
derivatives
Prior art date
Application number
EA201892734A
Other languages
Russian (ru)
Other versions
EA037871B1 (en
Inventor
Изабелль Ноэлль Констанс Пилатт
Оливье Алексис Жорж Керолль
Патрик Рене Анжибо
Дидье Жан-Клод Бертело
Софи Купа
Кристоф Габриэль Марсель Деместр
Ливен Мерпул
Гийом Жан Морис Мерсе
Лоранс Анна Мевеллек
Кристоф Мейер
Элизабет Терез Жанн Паскье
Виржини Софи Понселе
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201892734A1 publication Critical patent/EA201892734A1/en
Publication of EA037871B1 publication Critical patent/EA037871B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к производным азабензимидазола формулы (I)где переменные имеют значения, определенные в формуле изобретения. Соединения согласно настоящему изобретению являются пригодными в качестве ингибиторов pI3Kβ. Кроме того, настоящее изобретение относится к фармацевтическим композициям, содержащим указанные соединения в качестве активного ингредиента, а также к применению указанных соединений в качестве лекарственного препарата.The present invention relates to derivatives of azabenzimidazole of the formula (I) where the variables have the meanings defined in the claims. The compounds of the present invention are useful as inhibitors of pI3Kβ. In addition, the present invention relates to pharmaceutical compositions containing these compounds as an active ingredient, as well as the use of these compounds as a medicine.

EA201892734A 2016-06-16 2017-06-15 AZABENZIMIDAZOLE DERIVATIVES AS pI3K BETA INHIBITORS EA037871B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16174712 2016-06-16
PCT/EP2017/064672 WO2017216293A1 (en) 2016-06-16 2017-06-15 Azabenzimidazole derivatives as pi3k beta inhibitors

Publications (2)

Publication Number Publication Date
EA201892734A1 true EA201892734A1 (en) 2019-05-31
EA037871B1 EA037871B1 (en) 2021-05-28

Family

ID=56132833

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892734A EA037871B1 (en) 2016-06-16 2017-06-15 AZABENZIMIDAZOLE DERIVATIVES AS pI3K BETA INHIBITORS

Country Status (13)

Country Link
US (1) US20190263804A1 (en)
EP (1) EP3472147B1 (en)
JP (1) JP7158286B2 (en)
KR (1) KR102472198B1 (en)
CN (1) CN109311843B (en)
AU (1) AU2017286380B2 (en)
BR (1) BR112018076169A2 (en)
CA (1) CA3025746A1 (en)
EA (1) EA037871B1 (en)
ES (1) ES2818620T3 (en)
IL (1) IL263653A (en)
MX (1) MX2018015709A (en)
WO (1) WO2017216293A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3904350T3 (en) 2018-04-12 2024-02-19 Bayer Aktiengesellschaft N-(cyclopropylmethyl)-5-(methylsulfonyl)-n-{1-[1-(pyrimidin-2-yl)-1h-1,2,4-triazol-5-yl]ethyl}benzamide derivatives and the corresponding pyridine-carboxamide derivatives as pesticides
WO2019209811A1 (en) 2018-04-24 2019-10-31 Bristol-Myers Squibb Company Macrocyclic toll-like receptor 7 (tlr7) agonists
WO2019206799A1 (en) 2018-04-25 2019-10-31 Bayer Aktiengesellschaft Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides
US11554120B2 (en) 2018-08-03 2023-01-17 Bristol-Myers Squibb Company 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
TW202118391A (en) 2019-07-23 2021-05-16 德商拜耳廠股份有限公司 Novel heteroaryl-triazole compounds as pesticides
CN110551101B (en) * 2019-08-28 2020-11-24 沈阳药科大学 1. 6-disubstituted-benzo five-membered heterocyclic derivative and application thereof
MX2022004367A (en) 2019-10-09 2022-05-06 Bayer Ag Novel heteroaryl-triazole compounds as pesticides.
KR20220132591A (en) 2020-01-27 2022-09-30 브리스톨-마이어스 스큅 컴퍼니 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists
EP4097107A1 (en) 2020-01-27 2022-12-07 Bristol-Myers Squibb Company C3-substituted 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists
US20230144824A1 (en) 2020-01-27 2023-05-11 Bristol-Myers Squibb Company 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
JP2023512206A (en) 2020-01-27 2023-03-24 ブリストル－マイヤーズ スクイブ カンパニー 1H-pyrazolo[4,3-d]pyrimidine compounds as Toll-like receptor 7 (TLR7) agonists
EP4097103A1 (en) 2020-01-27 2022-12-07 Bristol-Myers Squibb Company 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists
KR20220132594A (en) 2020-01-27 2022-09-30 브리스톨-마이어스 스큅 컴퍼니 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists
CN115210236A (en) 2020-01-27 2022-10-18 百时美施贵宝公司 1H-pyrazolo [4,3-d ] pyrimidine compounds as Toll-like receptor 7 (TLR 7) agonists
EP4097105A1 (en) 2020-01-27 2022-12-07 Bristol-Myers Squibb Company 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists
KR20220132601A (en) 2020-01-27 2022-09-30 브리스톨-마이어스 스큅 컴퍼니 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists
CN118715012A (en) * 2022-02-18 2024-09-27 西藏海思科制药有限公司 Pyrazolopyridine derivative and application thereof in medicine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177074A (en) * 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
EP1993537A4 (en) 2006-03-02 2010-05-19 Glaxosmithkline Llc Thiazolones for use as pi3 kinase inhibitors
EP2046333A4 (en) 2006-07-24 2010-09-15 Glaxosmithkline Llc Thiozolidinedione derivatives as p13 kinase inhibitors
JP2010535804A (en) 2007-08-09 2010-11-25 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Quinoxaline derivatives as PI3 kinase inhibitors
BRPI0817503B8 (en) 2007-10-05 2021-05-25 Sstarbio Pte Ltd pyrimidine substituted purine derivatives, pharmaceutical composition comprising said compounds and use thereof for the prevention or treatment of a proliferative condition
US8703777B2 (en) 2008-01-04 2014-04-22 Intellikine Llc Certain chemical entities, compositions and methods
SG178454A1 (en) 2009-08-17 2012-03-29 Intellikine Inc Heterocyclic compounds and uses thereof
AU2010300719A1 (en) 2009-09-29 2012-05-03 Xcovery Holding Company Llc PI3K (delta) selective inhibitors
UY33304A (en) 2010-04-02 2011-10-31 Amgen Inc HETEROCYCLIC COMPOUNDS AND THEIR USES
LT2624696T (en) 2010-10-06 2017-03-10 Glaxosmithkline Llc Benzimidazole derivatives as pi3 kinase inhibitors
JP5808826B2 (en) 2011-02-23 2015-11-10 インテリカイン， エルエルシー Heterocyclic compounds and uses thereof
WO2013028263A1 (en) 2011-08-24 2013-02-28 Glaxosmithkline Llc Pyrazolopyrimidine derivatives as pi3 kinase inhibitors
US8778937B2 (en) 2011-12-20 2014-07-15 Glaxosmithkline Llc Benzimidazole boronic acid derivatives as PI3 kinase inhibitors
US8906910B2 (en) 2011-12-20 2014-12-09 Glaxosmithkline Llc Imidazopyridine derivatives as PI3 kinase

Also Published As

Publication number Publication date
EP3472147B1 (en) 2020-06-17
CN109311843B (en) 2021-10-08
EA037871B1 (en) 2021-05-28
IL263653A (en) 2019-01-31
CA3025746A1 (en) 2017-12-21
KR20190016976A (en) 2019-02-19
JP2019518059A (en) 2019-06-27
ES2818620T3 (en) 2021-04-13
AU2017286380A1 (en) 2018-12-06
EP3472147A1 (en) 2019-04-24
BR112018076169A2 (en) 2019-03-26
KR102472198B1 (en) 2022-11-28
MX2018015709A (en) 2019-03-21
AU2017286380B2 (en) 2021-02-04
WO2017216293A1 (en) 2017-12-21
US20190263804A1 (en) 2019-08-29
CN109311843A (en) 2019-02-05
JP7158286B2 (en) 2022-10-21

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM