EA201892377A1 - COMPOSITION ANTI-α4β7 ANTIBODIES - Google Patents

COMPOSITION ANTI-α4β7 ANTIBODIES

Info

Publication number
EA201892377A1
EA201892377A1 EA201892377A EA201892377A EA201892377A1 EA 201892377 A1 EA201892377 A1 EA 201892377A1 EA 201892377 A EA201892377 A EA 201892377A EA 201892377 A EA201892377 A EA 201892377A EA 201892377 A1 EA201892377 A1 EA 201892377A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
antibody
present
composition anti
antibody compositions
Prior art date
Application number
EA201892377A
Other languages
Russian (ru)
Other versions
EA034583B1 (en
Inventor
Уиллоу Дилузио
Нобель Т. Труонг
Ксанад М. Варга
Ваитхианатхан Паланиаппан
Джейсон Браун
Ирвинг Х. Фокс
Кэтрин Сколз
Original Assignee
Милленниум Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Милленниум Фармасьютикалз, Инк. filed Critical Милленниум Фармасьютикалз, Инк.
Publication of EA201892377A1 publication Critical patent/EA201892377A1/en
Publication of EA034583B1 publication Critical patent/EA034583B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

Описаны композиции антител, содержащие смесь невосстанавливающего сахара, анти-α4β7 антитела и по меньшей мере одной аминокислоты. Раскрытые композиции обладают улучшенной стабильностью, пониженным образованием агрегатов и могут замедлять деградацию содержащегося в них анти-α4β7 антитела по настоящему изобретению или демонстрируют любые комбинации этих характеристик. Настоящее изобретение дополнительно предусматривает безопасный режим дозирования таких композиций антител, простой в реализации и обеспечивающий терапевтически эффективное количество анти-α4β7 антител in vivo.Antibody compositions containing a mixture of non reducing sugar, anti-α4β7 antibody and at least one amino acid are described. The disclosed compositions have improved stability, reduced formation of aggregates and can slow down the degradation of the anti-α4β7 antibodies contained in them according to the present invention or demonstrate any combination of these characteristics. The present invention further provides a safe dosing regimen of such antibody compositions, which is simple to implement and provides a therapeutically effective amount of anti-α4β7 antibodies in vivo.

EA201892377A 2012-01-12 2012-05-02 USES OF ANTI-α4β7 ANTIBODY EA034583B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261585859P 2012-01-12 2012-01-12

Publications (2)

Publication Number Publication Date
EA201892377A1 true EA201892377A1 (en) 2019-03-29
EA034583B1 EA034583B1 (en) 2020-02-21

Family

ID=54360587

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201992881A EA201992881A3 (en) 2012-01-12 2012-05-02 ANTI-47 ANTIBODY COMPOSITION
EA201892377A EA034583B1 (en) 2012-01-12 2012-05-02 USES OF ANTI-α4β7 ANTIBODY

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201992881A EA201992881A3 (en) 2012-01-12 2012-05-02 ANTI-47 ANTIBODY COMPOSITION

Country Status (2)

Country Link
EA (2) EA201992881A3 (en)
TN (1) TN2013000442A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114746439A (en) * 2019-10-11 2022-07-12 雷迪博士实验室有限公司 Stable formulations of integrin antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7147851B1 (en) * 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
US20010046496A1 (en) * 2000-04-14 2001-11-29 Brettman Lee R. Method of administering an antibody
EP1948691A1 (en) * 2005-11-17 2008-07-30 Millennium Pharmaceuticals, Inc. HUMANIZED IMMUNOGLOBULIN REACTIVE WITH a4ß7INTEGRIN

Also Published As

Publication number Publication date
EA201992881A3 (en) 2020-12-30
EA034583B1 (en) 2020-02-21
EA201992881A2 (en) 2020-09-30
TN2013000442A1 (en) 2015-03-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM