EA201892302A1 - Ингибиторы бромодомена - Google Patents
Ингибиторы бромодоменаInfo
- Publication number
- EA201892302A1 EA201892302A1 EA201892302A EA201892302A EA201892302A1 EA 201892302 A1 EA201892302 A1 EA 201892302A1 EA 201892302 A EA201892302 A EA 201892302A EA 201892302 A EA201892302 A EA 201892302A EA 201892302 A1 EA201892302 A1 EA 201892302A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- compositions
- bromodomain inhibitors
- bromodomain
- acetyllysine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее изобретение относится к замещенным гетероциклическим соединениям, композициям, содержащим указанные соединения, и применению указанных соединений и композиций для эпигенетической регуляции путем ингибирования бромодомен-опосредованного распознавания ацетиллизиновых областей белков, таких как гистоны. Указанные композиции и способы могут быть использованы для лечения рака и неопластических заболеваний.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461931467P | 2014-01-24 | 2014-01-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201892302A1 true EA201892302A1 (ru) | 2019-03-29 |
EA038715B1 EA038715B1 (ru) | 2021-10-08 |
Family
ID=65950003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201892302A EA038715B1 (ru) | 2014-01-24 | 2014-10-17 | Ингибиторы бромодомена |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA038715B1 (ru) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004276236B2 (en) * | 2003-09-23 | 2008-01-24 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
GB0919434D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
-
2014
- 2014-10-17 EA EA201892302A patent/EA038715B1/ru unknown
Also Published As
Publication number | Publication date |
---|---|
EA038715B1 (ru) | 2021-10-08 |
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