EA201891690A1 - Агонист fxr, представляющий собой производное стероидов - Google Patents
Агонист fxr, представляющий собой производное стероидовInfo
- Publication number
- EA201891690A1 EA201891690A1 EA201891690A EA201891690A EA201891690A1 EA 201891690 A1 EA201891690 A1 EA 201891690A1 EA 201891690 A EA201891690 A EA 201891690A EA 201891690 A EA201891690 A EA 201891690A EA 201891690 A1 EA201891690 A1 EA 201891690A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- presenting
- fxr agonist
- steroid derivative
- relates
- fxr
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Abstract
Изобретение относится к соединению, представленному посредством формулы (I), его таутомеру или его фармацевтически приемлемой соли, а также относится к путям их применения в получении независимых средств для лечения заболеваний, связанных с FXR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610331759 | 2016-05-18 | ||
PCT/CN2017/072567 WO2017129125A1 (zh) | 2016-01-28 | 2017-01-25 | 甾体类衍生物fxr激动剂 |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201891690A1 true EA201891690A1 (ru) | 2019-04-30 |
EA038580B1 EA038580B1 (ru) | 2021-09-17 |
EA038580B9 EA038580B9 (ru) | 2021-10-05 |
Family
ID=66436959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201891690A EA038580B9 (ru) | 2016-05-18 | 2017-01-25 | Агонист fxr, представляющий собой производное стероидов |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA038580B9 (ru) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE48286E1 (en) * | 2001-03-12 | 2020-10-27 | Intercept Pharmaceuticals, Inc. | Steroids as agonists for FXR |
EP1568706A1 (en) * | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
WO2016086134A1 (en) * | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
US10208081B2 (en) * | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
EP3277286B1 (en) * | 2015-03-31 | 2021-04-21 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
CN106083978A (zh) * | 2015-04-28 | 2016-11-09 | 上海迪诺医药科技有限公司 | 磺酰基氨基羰基衍生物、其药物组合物及应用 |
US20180148470A1 (en) * | 2015-04-28 | 2018-05-31 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Cholic acid derivative, and preparation method and medical use thereof |
-
2017
- 2017-01-25 EA EA201891690A patent/EA038580B9/ru unknown
Also Published As
Publication number | Publication date |
---|---|
EA038580B1 (ru) | 2021-09-17 |
EA038580B9 (ru) | 2021-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TH4A | Publication of the corrected specification to eurasian patent |