EA201891690A1 - FXR AGONIST, PRESENTING STEROID DERIVATIVE - Google Patents

FXR AGONIST, PRESENTING STEROID DERIVATIVE

Info

Publication number
EA201891690A1
EA201891690A1 EA201891690A EA201891690A EA201891690A1 EA 201891690 A1 EA201891690 A1 EA 201891690A1 EA 201891690 A EA201891690 A EA 201891690A EA 201891690 A EA201891690 A EA 201891690A EA 201891690 A1 EA201891690 A1 EA 201891690A1
Authority
EA
Eurasian Patent Office
Prior art keywords
presenting
fxr agonist
steroid derivative
relates
fxr
Prior art date
Application number
EA201891690A
Other languages
Russian (ru)
Other versions
EA038580B9 (en
EA038580B1 (en
Inventor
Хайин Хэ
Хуалин Сяо
Пэн ЛИ
Чуньянь Ду
Чжи Ло
Шухуэй Чэнь
Original Assignee
Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. filed Critical Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд.
Priority claimed from PCT/CN2017/072567 external-priority patent/WO2017129125A1/en
Publication of EA201891690A1 publication Critical patent/EA201891690A1/en
Publication of EA038580B1 publication Critical patent/EA038580B1/en
Publication of EA038580B9 publication Critical patent/EA038580B9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Abstract

Изобретение относится к соединению, представленному посредством формулы (I), его таутомеру или его фармацевтически приемлемой соли, а также относится к путям их применения в получении независимых средств для лечения заболеваний, связанных с FXR.The invention relates to the compound represented by the formula (I), its tautomer or its pharmaceutically acceptable salt, and also relates to the ways of their use in obtaining independent agents for treating diseases associated with FXR.

EA201891690A 2016-05-18 2017-01-25 Steroid derivative fxr agonist EA038580B9 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610331759 2016-05-18
PCT/CN2017/072567 WO2017129125A1 (en) 2016-01-28 2017-01-25 Steroid derivative fxr agonist

Publications (3)

Publication Number Publication Date
EA201891690A1 true EA201891690A1 (en) 2019-04-30
EA038580B1 EA038580B1 (en) 2021-09-17
EA038580B9 EA038580B9 (en) 2021-10-05

Family

ID=66436959

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891690A EA038580B9 (en) 2016-05-18 2017-01-25 Steroid derivative fxr agonist

Country Status (1)

Country Link
EA (1) EA038580B9 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1392714B1 (en) * 2001-03-12 2005-08-31 Intercept Pharmaceuticals, Inc. Steroids as agonists for fxr
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
WO2016086134A1 (en) * 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
US10208081B2 (en) * 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
ES2886766T3 (en) * 2015-03-31 2021-12-20 Enanta Pharm Inc Bile acid derivatives as FXR/TGR5 agonists and methods of using these
CN107250150B (en) * 2015-04-28 2019-11-22 江苏豪森药业集团有限公司 Chlolic acid derivatives and preparation method thereof and medical usage
CN106083978A (en) * 2015-04-28 2016-11-09 上海迪诺医药科技有限公司 Sulfonyl amino carbonyl derivant, its pharmaceutical composition and application

Also Published As

Publication number Publication date
EA038580B9 (en) 2021-10-05
EA038580B1 (en) 2021-09-17

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Legal Events

Date Code Title Description
TH4A Publication of the corrected specification to eurasian patent