EA201800506A1 - METHOD FOR PRODUCING COMPOSITION FOR MAKING CAPSULES (OPTIONS) - Google Patents

METHOD FOR PRODUCING COMPOSITION FOR MAKING CAPSULES (OPTIONS)

Info

Publication number
EA201800506A1
EA201800506A1 EA201800506A EA201800506A EA201800506A1 EA 201800506 A1 EA201800506 A1 EA 201800506A1 EA 201800506 A EA201800506 A EA 201800506A EA 201800506 A EA201800506 A EA 201800506A EA 201800506 A1 EA201800506 A1 EA 201800506A1
Authority
EA
Eurasian Patent Office
Prior art keywords
agar
sodium humate
glycerin
stirred
heated
Prior art date
Application number
EA201800506A
Other languages
Russian (ru)
Other versions
EA035605B1 (en
Inventor
Фархад Сабир оглы Омаров
Original Assignee
Товарищество С Ограниченной Ответственностью "Bioteknistik" (Биотекнистик)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Товарищество С Ограниченной Ответственностью "Bioteknistik" (Биотекнистик) filed Critical Товарищество С Ограниченной Ответственностью "Bioteknistik" (Биотекнистик)
Publication of EA201800506A1 publication Critical patent/EA201800506A1/en
Publication of EA035605B1 publication Critical patent/EA035605B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к химико-фармацевтической промышленности и касается создания нового состава агаровых и/или желатиновых масс для изготовления капсул, заполняемых маслорастворимыми веществами на гидрофобной основе, диспергированными масляными эмульсиями, а также биологически активной биомассой или лекарственными препаратами. Достигаемый результат - повышение качества агаровых или желатиновых капсул за счет улучшения антимикробной защиты и светозащиты ценных биоорганических субстанций (начинки капсул). Указанный результат достигается тем, что в первом варианте способа получения композиции для изготовления капсул дополнительно вводят гумат натрия в виде 0,5-5,0% раствора, при этом раствор гумата натрия и глицерин вводят в реактор, нагревают до 60-65°C и перемешивают, затем добавляют агар-агар, перемешивают и нагревают до 90-95°C, из расплавленной массы удаляют воздух, а затем выдерживают при атмосферном давлении до 12 ч при температуре 65-75°C при следующем соотношении компонентов, мас.%: агар-агар 5-8; глицерин 8-13; гумат натрия 0,5-2,5; вода - остальное. Второй вариант способа характеризуется тем, что дополнительно вводят гумат натрия в виде 0,5-5,0% раствора, а в качестве гелеобразующего агента используют желатин, при этом раствор гумата натрия и глицерин вводят в реактор, нагревают до 60-75°C и перемешивают, затем добавляют желатин, перемешивают и нагревают до 75-80°C, из расплавленной массы удаляют воздух, а затем выдерживают при атмосферном давлении до 12 ч при температуре 65-70°C при следующем соотношении компонентов, мас.%: желатин 30-42; глицерин 8-13; гумат натрия 0,5-2,5; вода - остальное.The invention relates to the chemical-pharmaceutical industry and concerns the creation of a new composition of agar and / or gelatinous masses for the manufacture of capsules filled with oil-soluble substances on a hydrophobic basis, dispersed oil emulsions, as well as biologically active biomass or drugs. The achieved result is an increase in the quality of agar or gelatin capsules by improving antimicrobial protection and light protection of valuable bioorganic substances (capsule fillings). This result is achieved by the fact that in the first variant of the method for preparing a composition for the manufacture of capsules, sodium humate is additionally introduced in the form of a 0.5-5.0% solution, while the sodium humate solution and glycerin are introduced into the reactor, heated to 60-65 ° C and agar is stirred, then agar-agar is added, stirred and heated to 90-95 ° C, air is removed from the molten mass, and then kept at atmospheric pressure for up to 12 hours at a temperature of 65-75 ° C at the following ratio of components, wt%: agar -agar 5-8; glycerin 8-13; sodium humate 0.5-2.5; water is the rest. The second variant of the method is characterized by the fact that sodium humate is additionally introduced in the form of a 0.5-5.0% solution, and gelatin is used as a gelling agent, while a sodium humate solution and glycerin are introduced into the reactor, heated to 60-75 ° C and stirred, then gelatin is added, stirred and heated to 75-80 ° C, air is removed from the molten mass, and then kept at atmospheric pressure for up to 12 hours at a temperature of 65-70 ° C at the following ratio of components, wt%: gelatin 30- 42; glycerin 8-13; sodium humate 0.5-2.5; water is the rest.

EA201800506A 2018-07-18 2018-09-10 Method of preparing a composition to produce capsules (embodiments) EA035605B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KZ20180519 2018-07-18

Publications (2)

Publication Number Publication Date
EA201800506A1 true EA201800506A1 (en) 2020-01-31
EA035605B1 EA035605B1 (en) 2020-07-15

Family

ID=69374467

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201800506A EA035605B1 (en) 2018-07-18 2018-09-10 Method of preparing a composition to produce capsules (embodiments)

Country Status (1)

Country Link
EA (1) EA035605B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113713722A (en) * 2021-08-13 2021-11-30 河海大学 Preparation method of EPS-like agarose-based hydrogel and application of EPS-like agarose-based hydrogel in adsorption and dephosphorization

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2104693C1 (en) * 1995-11-15 1998-02-20 Акционерное общество открытого типа "Нижегородский химико-фармацевтический завод" Gelatin mass composition for capsule making
RU2569742C1 (en) * 2014-10-23 2015-11-27 Закрытое акционерное общество "Санкт-Петербургский институт фармации" Enteric-coated soft capsule and method for producing it

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113713722A (en) * 2021-08-13 2021-11-30 河海大学 Preparation method of EPS-like agarose-based hydrogel and application of EPS-like agarose-based hydrogel in adsorption and dephosphorization
CN113713722B (en) * 2021-08-13 2024-06-11 河海大学 Preparation method of EPS-like agarose-based hydrogel and application of EPS-like agarose-based hydrogel in adsorption dephosphorization

Also Published As

Publication number Publication date
EA035605B1 (en) 2020-07-15

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