EA201791442A1 - METHODS OF TREATMENT OF HEMATOLOGICAL DISTURBANCES, SOLID TUMORS OR INFECTIOUS DISEASES WITH THE USE OF NATURAL CELL-CALLERS - Google Patents
METHODS OF TREATMENT OF HEMATOLOGICAL DISTURBANCES, SOLID TUMORS OR INFECTIOUS DISEASES WITH THE USE OF NATURAL CELL-CALLERSInfo
- Publication number
- EA201791442A1 EA201791442A1 EA201791442A EA201791442A EA201791442A1 EA 201791442 A1 EA201791442 A1 EA 201791442A1 EA 201791442 A EA201791442 A EA 201791442A EA 201791442 A EA201791442 A EA 201791442A EA 201791442 A1 EA201791442 A1 EA 201791442A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- callers
- treatment
- infectious diseases
- solid tumors
- Prior art date
Links
- 208000035473 Communicable disease Diseases 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002489 hematologic effect Effects 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 2
- 238000012239 gene modification Methods 0.000 abstract 1
- 230000005017 genetic modification Effects 0.000 abstract 1
- 235000013617 genetically modified food Nutrition 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
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- Health & Medical Sciences (AREA)
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Abstract
В настоящем раскрытии предоставлены способы лечения гематологического нарушения, солидной опухоли или инфекционного заболевания у нуждающегося в этом субъекта с применением естественных клеток-киллеров в комбинации со вторым средством или с применением NK-клеток с генетическими модификациями для специфичности нацеливания и/или специфичности хоминга.In the present disclosure, methods are provided for treating a hematological disorder, a solid tumor or an infectious disease in a subject in need thereof using natural killer cells in combination with a second agent or using NK cells with genetic modifications for targeting specificity and / or homing specificity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562139952P | 2015-03-30 | 2015-03-30 | |
PCT/US2015/068069 WO2016109668A1 (en) | 2014-12-31 | 2015-12-30 | Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells |
Publications (2)
Publication Number | Publication Date |
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EA201791442A1 true EA201791442A1 (en) | 2018-05-31 |
EA039192B1 EA039192B1 (en) | 2021-12-16 |
Family
ID=80632888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791442A EA039192B1 (en) | 2015-03-30 | 2015-12-30 | Method of treating cancer and kit for treating cancer |
Country Status (1)
Country | Link |
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EA (1) | EA039192B1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2728361C1 (en) * | 2019-10-16 | 2020-07-29 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Biomedical cell product with anti-her2 specific anti-tumour activity |
RU2786210C1 (en) * | 2022-10-07 | 2022-12-19 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | BIOMEDICAL CELL PRODUCT WITH SPECIFIC ANTITUMOR ACTIVITY, REPRESENTED BY POPULATIONS OF LYMPHOKINE-ACTIVATED KILLERS AND ANTI-HER2 CAR-γδΤ-OIL AND ANTI-HER2 CAR-T-NK |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6850528B2 (en) * | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | Bispecific chimeric antigen receptor and its therapeutic use |
EP2970426B1 (en) * | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
-
2015
- 2015-12-30 EA EA201791442A patent/EA039192B1/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2728361C1 (en) * | 2019-10-16 | 2020-07-29 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Biomedical cell product with anti-her2 specific anti-tumour activity |
RU2786210C1 (en) * | 2022-10-07 | 2022-12-19 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | BIOMEDICAL CELL PRODUCT WITH SPECIFIC ANTITUMOR ACTIVITY, REPRESENTED BY POPULATIONS OF LYMPHOKINE-ACTIVATED KILLERS AND ANTI-HER2 CAR-γδΤ-OIL AND ANTI-HER2 CAR-T-NK |
Also Published As
Publication number | Publication date |
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EA039192B1 (en) | 2021-12-16 |
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