EA201790891A1 - Способ получения полиморфа ривароксабана - Google Patents

Способ получения полиморфа ривароксабана

Info

Publication number
EA201790891A1
EA201790891A1 EA201790891A EA201790891A EA201790891A1 EA 201790891 A1 EA201790891 A1 EA 201790891A1 EA 201790891 A EA201790891 A EA 201790891A EA 201790891 A EA201790891 A EA 201790891A EA 201790891 A1 EA201790891 A1 EA 201790891A1
Authority
EA
Eurasian Patent Office
Prior art keywords
solvent
rivaroxaban
polymorph
obtaining
obtaining rivaroxaban
Prior art date
Application number
EA201790891A
Other languages
English (en)
Other versions
EA034656B1 (ru
Inventor
Кароль Саголь
Магдалена Козен-Сайног
Original Assignee
Закляды Фармацеутычне Польфарма С.А
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Закляды Фармацеутычне Польфарма С.А filed Critical Закляды Фармацеутычне Польфарма С.А
Publication of EA201790891A1 publication Critical patent/EA201790891A1/ru
Publication of EA034656B1 publication Critical patent/EA034656B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Настоящее изобретение относится к способу получения модификации I ривароксабана, включающему: (i) растворение ривароксабана в смеси растворителя (например, ТГФ) и антирастворителя (например, воды и/или толуола), в котором антирастворитель имеет более высокую температуру кипения, чем растворитель; (ii) удаление растворителя путем отгонки; (iii) сбор полученной модификации I ривароксабана.
EA201790891A 2014-10-22 2015-10-22 Способ получения полиморфа ривароксабана EA034656B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14460075 2014-10-22
PCT/EP2015/074538 WO2016062828A1 (en) 2014-10-22 2015-10-22 Process for preparing a polymorph of rivaroxaban

Publications (2)

Publication Number Publication Date
EA201790891A1 true EA201790891A1 (ru) 2017-08-31
EA034656B1 EA034656B1 (ru) 2020-03-03

Family

ID=51904938

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790891A EA034656B1 (ru) 2014-10-22 2015-10-22 Способ получения полиморфа ривароксабана

Country Status (5)

Country Link
US (1) US10040786B2 (ru)
EP (1) EP3209661B1 (ru)
EA (1) EA034656B1 (ru)
PL (1) PL3209661T3 (ru)
WO (1) WO2016062828A1 (ru)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2225901A (en) 1999-12-28 2001-07-09 Ajinomoto Co., Inc. Aspartame derivative crystals
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE102004002044A1 (de) 2004-01-15 2005-08-04 Bayer Healthcare Ag Herstellverfahren
EP1934208B1 (de) 2005-10-04 2011-03-23 Bayer Schering Pharma Aktiengesellschaft Neue polymorphe form von 5-chlor-n-({ ( 5s )-2-0x0-3-[4-( 3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl} -methyl)-2-thiophencarboxamid
SI2459555T1 (sl) * 2009-07-31 2022-03-31 Krka, D.D., Novo Mesto Postopek kristalizacije rivaroksabana
EP3309158B1 (en) * 2012-12-21 2022-03-16 Krka, tovarna zdravil, d.d. Crystalline form k of rivaroxaban and process for its preparation
WO2015111076A2 (en) * 2014-01-23 2015-07-30 Symed Labs Limited Improved processes for the preparation of highly pure rivaroxaban crystal modification i

Also Published As

Publication number Publication date
EA034656B1 (ru) 2020-03-03
EP3209661B1 (en) 2021-02-17
US20170313689A1 (en) 2017-11-02
US10040786B2 (en) 2018-08-07
EP3209661A1 (en) 2017-08-30
PL3209661T3 (pl) 2021-08-16
WO2016062828A1 (en) 2016-04-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM