EA201790453A3 - NEW SALT OF THE ACCESSION OF ACID 1- (5- (2,4-DIFTORFENYL) -1 - ((3-FLUORPHENYL) SULFONILE) -4-METHOXY-1H-PYRROL-3-IL) -N-METHYLMETHANAMINE - Google Patents

NEW SALT OF THE ACCESSION OF ACID 1- (5- (2,4-DIFTORFENYL) -1 - ((3-FLUORPHENYL) SULFONILE) -4-METHOXY-1H-PYRROL-3-IL) -N-METHYLMETHANAMINE

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Publication number
EA201790453A3
EA201790453A3 EA201790453A EA201790453A EA201790453A3 EA 201790453 A3 EA201790453 A3 EA 201790453A3 EA 201790453 A EA201790453 A EA 201790453A EA 201790453 A EA201790453 A EA 201790453A EA 201790453 A3 EA201790453 A3 EA 201790453A3
Authority
EA
Eurasian Patent Office
Prior art keywords
methylmethanamine
pyrrol
methoxy
sulfonile
diftorfenyl
Prior art date
Application number
EA201790453A
Other languages
Russian (ru)
Other versions
EA201790453A2 (en
EA029788B1 (en
Inventor
Аэри Ким
Кван Хиунг Чо
Original Assignee
Даевунг Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020170018336A external-priority patent/KR20170113040A/en
Application filed by Даевунг Фармасьютикал Ко., Лтд. filed Critical Даевунг Фармасьютикал Ко., Лтд.
Publication of EA201790453A2 publication Critical patent/EA201790453A2/en
Publication of EA201790453A3 publication Critical patent/EA201790453A3/en
Publication of EA029788B1 publication Critical patent/EA029788B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms

Abstract

В настоящем изобретении предложена новая соль присоединения кислоты 1-(5-(2,4-дифторфенил)-1-((3-фторфенил)сульфонил)-4-метокси-1Н-пиррол-3-ил)-N-метилметанамина. Вышеуказанная соль присоединения кислоты обладает не только превосходной ингибирующей активностью в отношении протонной помпы, ингибирующей активностью в отношении желудочных повреждений и эффектом повышения защитного фактора, но также превосходной активностью в отношении уничтожения Н. Pylori, и, таким образом, ее можно эффективно использовать для предупреждения и лечения желудочно-кишечных поражений, вызванных язвой желудочно-кишечного тракта, гастритом, рефлюксным эзофагитом или Н. pylori.The present invention provides a novel acid addition salt of 1- (5- (2,4-difluorophenyl) -1 - ((3-fluorophenyl) sulfonyl) -4-methoxy-1H-pyrrol-3-yl) -N-methylmethanamine. The above acid addition salt has not only an excellent inhibitory activity against the proton pump, an inhibitory activity against gastric lesions and the effect of enhancing the protective factor, but also an excellent activity against the destruction of H. Pylori, and thus can be effectively used to prevent and treatment of gastrointestinal lesions caused by an ulcer of the gastrointestinal tract, gastritis, reflux esophagitis, or H. pylori.

EA201790453A 2016-03-25 2017-03-23 Novel acid addition salt of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine EA029788B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160036081 2016-03-25
KR1020170018336A KR20170113040A (en) 2016-03-25 2017-02-09 Novel acid addition salt of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine

Publications (3)

Publication Number Publication Date
EA201790453A2 EA201790453A2 (en) 2017-09-29
EA201790453A3 true EA201790453A3 (en) 2017-11-30
EA029788B1 EA029788B1 (en) 2018-05-31

Family

ID=59899552

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790453A EA029788B1 (en) 2016-03-25 2017-03-23 Novel acid addition salt of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine

Country Status (2)

Country Link
EA (1) EA029788B1 (en)
WO (1) WO2017164575A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102233455B1 (en) 2017-06-21 2021-03-29 주식회사 대웅제약 Method for preparation of intermediate of 4-methoxypyrrole derivative
KR102126576B1 (en) * 2018-09-19 2020-06-24 주식회사 대웅제약 Manufacturing method for 4-methoxypyrrole derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1803709B1 (en) 2004-09-30 2013-01-02 Takeda Pharmaceutical Company Limited Proton pump inhibitors
JP5207964B2 (en) * 2006-03-31 2013-06-12 武田薬品工業株式会社 Acid secretion inhibitor
US20100113524A1 (en) * 2006-09-19 2010-05-06 Garst Michael E Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
JP6292736B2 (en) * 2012-11-19 2018-03-14 ジエンス ハンセン ファーマセウティカル カンパニー リミテッド Pyrrolesulfonamide derivative, its production method and its medical use
CN104447491B (en) * 2014-11-19 2017-06-23 连云港恒运医药有限公司 Hemifumarate and its intermediate and medical usage containing pyrrole ring proton pump inhibitor
KR101613245B1 (en) * 2015-04-27 2016-04-18 주식회사 대웅제약 Novel 4-methoxy pyrrole derivatives or salts thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
WO2017164575A1 (en) 2017-09-28
EA201790453A2 (en) 2017-09-29
EA029788B1 (en) 2018-05-31

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