EA201691202A1 - FLAGELLIN-CONTAINING PROTEIN NANOPARTICLES AS A PLATFORM FOR VACCINE - Google Patents
FLAGELLIN-CONTAINING PROTEIN NANOPARTICLES AS A PLATFORM FOR VACCINEInfo
- Publication number
- EA201691202A1 EA201691202A1 EA201691202A EA201691202A EA201691202A1 EA 201691202 A1 EA201691202 A1 EA 201691202A1 EA 201691202 A EA201691202 A EA 201691202A EA 201691202 A EA201691202 A EA 201691202A EA 201691202 A1 EA201691202 A1 EA 201691202A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- flagellin
- vaccine
- platform
- containing protein
- protein nanoparticles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Настоящее изобретение относится к белковым наночастицам, обладающим способностью самосборки, сконструированным из подходящих доменов олигомеризации и дополнительно включающих TLR5-связывающий белок флагеллин в качестве молекулы адъюванта. Более того, настоящее изобретение относится к применению таких наночастиц для вакцинации.The present invention relates to protein nanoparticles having the ability to self-assembly, constructed from suitable oligomerization domains and further comprising the TLR5 binding protein flagellin as an adjuvant molecule. Moreover, the present invention relates to the use of such nanoparticles for vaccination.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14189264 | 2014-10-16 | ||
PCT/EP2015/050289 WO2015104352A1 (en) | 2014-01-09 | 2015-01-09 | Flagellin-containing protein nanoparticles as a vaccine platform |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201691202A1 true EA201691202A1 (en) | 2017-01-30 |
EA037258B1 EA037258B1 (en) | 2021-02-26 |
EA037258B8 EA037258B8 (en) | 2022-02-22 |
Family
ID=51798969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201691202A EA037258B8 (en) | 2014-10-16 | 2015-01-09 | Flagellin-containing protein nanoparticles for immunomodulation |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA037258B8 (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013144579A1 (en) * | 2012-03-30 | 2013-10-03 | Heriot-Watt University | Use of flagellin as a vaccine |
-
2015
- 2015-01-09 EA EA201691202A patent/EA037258B8/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA037258B8 (en) | 2022-02-22 |
EA037258B1 (en) | 2021-02-26 |
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