EA201690784A1 - OBTAINING STERILE LIPOS WITH ANY SIZE OF PARTICLES BY CONTINUOUS EXTRUSION IN A CLOSED SYSTEM - Google Patents
OBTAINING STERILE LIPOS WITH ANY SIZE OF PARTICLES BY CONTINUOUS EXTRUSION IN A CLOSED SYSTEMInfo
- Publication number
- EA201690784A1 EA201690784A1 EA201690784A EA201690784A EA201690784A1 EA 201690784 A1 EA201690784 A1 EA 201690784A1 EA 201690784 A EA201690784 A EA 201690784A EA 201690784 A EA201690784 A EA 201690784A EA 201690784 A1 EA201690784 A1 EA 201690784A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- sterile
- size
- lipos
- particles
- closed system
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 3
- 238000001125 extrusion Methods 0.000 title 1
- 239000002502 liposome Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 239000011148 porous material Substances 0.000 abstract 2
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D37/00—Processes of filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
Способ получения липосом таким образом, что размер липосом обеспечивают посредством пропускания предварительно полученной дисперсии MLV через мембрану с соответствующим размером пор в другой контейнер и последующей рециркуляции ее обратно в первый контейнер через мембрану до тех пор, пока не будет достигнут требуемый размер частиц. Тип распределения частиц по размеру может быть задан произвольно по меньшей мере c 5%-ной точностью в зависимости от диаметра используемых пор и времени циркуляции. За счет использования стерильных или подвергнутых стерильной фильтрации ингредиентов и оборудования, все части которого стерилизованы, а также замкнутой производственной технологии процесс является асептическим, поэтому полученный липосомный продукт является стерильным.A method for producing liposomes such that the size of the liposomes is provided by passing the previously obtained MLV dispersion through a membrane with an appropriate pore size to another container and then recycling it back to the first container through the membrane until the required particle size is reached. The type of particle size distribution can be set arbitrarily at least with 5% accuracy depending on the diameter of the pores used and the circulation time. Through the use of sterile or sterile-filtered ingredients and equipment, all parts of which are sterilized, as well as a closed production technology, the process is aseptic, so the resulting liposomal product is sterile.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1300621A HUP1300621A2 (en) | 2013-10-31 | 2013-10-31 | Production of aseptic liposomes having optional dimension by continous, closed system |
| PCT/IB2014/065701 WO2015063710A1 (en) | 2013-10-31 | 2014-10-30 | Production of sterile liposomes of any particle sizes by continuous extrusion in a closed system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201690784A1 true EA201690784A1 (en) | 2016-11-30 |
Family
ID=89991302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201690784A EA201690784A1 (en) | 2013-10-31 | 2014-10-30 | OBTAINING STERILE LIPOS WITH ANY SIZE OF PARTICLES BY CONTINUOUS EXTRUSION IN A CLOSED SYSTEM |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3062773A1 (en) |
| EA (1) | EA201690784A1 (en) |
| HU (1) | HUP1300621A2 (en) |
| WO (1) | WO2015063710A1 (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4861580A (en) | 1985-10-15 | 1989-08-29 | The Liposome Company, Inc. | Composition using salt form of organic acid derivative of alpha-tocopheral |
| US4737323A (en) * | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US4927637A (en) | 1989-01-17 | 1990-05-22 | Liposome Technology, Inc. | Liposome extrusion method |
| CA2091776C (en) | 1990-10-05 | 1999-08-31 | Royden M. Coe | Liposome extrusion process |
-
2013
- 2013-10-31 HU HU1300621A patent/HUP1300621A2/en unknown
-
2014
- 2014-10-30 EA EA201690784A patent/EA201690784A1/en unknown
- 2014-10-30 EP EP14815015.4A patent/EP3062773A1/en not_active Withdrawn
- 2014-10-30 WO PCT/IB2014/065701 patent/WO2015063710A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP3062773A1 (en) | 2016-09-07 |
| HUP1300621A2 (en) | 2015-05-28 |
| WO2015063710A1 (en) | 2015-05-07 |
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