EA201591203A1 - COMPOSITION FOR CONNECTING ALDEHYDES IN THE ORAL CAVITY - Google Patents
COMPOSITION FOR CONNECTING ALDEHYDES IN THE ORAL CAVITYInfo
- Publication number
- EA201591203A1 EA201591203A1 EA201591203A EA201591203A EA201591203A1 EA 201591203 A1 EA201591203 A1 EA 201591203A1 EA 201591203 A EA201591203 A EA 201591203A EA 201591203 A EA201591203 A EA 201591203A EA 201591203 A1 EA201591203 A1 EA 201591203A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- composition
- aldehydes
- oral cavity
- toxic
- cysteine
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 150000001299 aldehydes Chemical class 0.000 title 1
- 210000000214 mouth Anatomy 0.000 title 1
- 239000000654 additive Substances 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- XUJNEKJLAYXESH-UWTATZPHSA-N D-Cysteine Chemical compound SC[C@@H](N)C(O)=O XUJNEKJLAYXESH-UWTATZPHSA-N 0.000 abstract 1
- 229930195710 D‐cysteine Natural products 0.000 abstract 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 abstract 1
- 229960004308 acetylcysteine Drugs 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000006189 buccal tablet Substances 0.000 abstract 1
- 150000001944 cysteine derivatives Chemical class 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 239000007937 lozenge Substances 0.000 abstract 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000006190 sub-lingual tablet Substances 0.000 abstract 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 abstract 1
- 229960002675 xylitol Drugs 0.000 abstract 1
- 235000010447 xylitol Nutrition 0.000 abstract 1
- 239000000811 xylitol Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к нетоксичной композиции в форме буккальных таблеток, подъязычных таблеток или леденцов, содержащей комбинацию активных агентов, включающую одно или несколько альдегид-связывающих цистеиновых соединений, выбранных из группы L- и D-цистеина, N-ацетилцистеина и их фармацевтически приемлемых солей, и ксилит, при этом указанная композиция дополнительно содержит одну или несколько нетоксичных добавок, которые включают один или несколько ароматизаторов, а также один или несколько наполнителей или связующих веществ или и то, и другое и необязательные дополнительные добавки.The invention relates to a non-toxic composition in the form of buccal tablets, sublingual tablets or lozenges containing a combination of active agents comprising one or more aldehyde-binding cysteine compounds selected from the group of L- and D-cysteine, N-acetylcysteine and their pharmaceutically acceptable salts, and xylitol, wherein said composition further comprises one or more non-toxic additives, which include one or more flavorings, as well as one or more fillers or binders, or Both optional and additional additives.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20135097A FI20135097L (en) | 2013-02-01 | 2013-02-01 | Composition for binding aldehydes in the mouth |
| PCT/FI2014/050076 WO2014118438A1 (en) | 2013-02-01 | 2014-01-31 | Composition for binding aldehydes in the mouth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201591203A1 true EA201591203A1 (en) | 2016-01-29 |
Family
ID=51261516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201591203A EA201591203A1 (en) | 2013-02-01 | 2014-01-31 | COMPOSITION FOR CONNECTING ALDEHYDES IN THE ORAL CAVITY |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2950794A4 (en) |
| CN (2) | CN108969500A (en) |
| EA (1) | EA201591203A1 (en) |
| FI (1) | FI20135097L (en) |
| MX (1) | MX2015009972A (en) |
| WO (1) | WO2014118438A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI127823B (en) * | 2015-03-06 | 2019-03-15 | Biohit Oyj | Composition for preventing hangover symptoms |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI121528B (en) * | 2000-10-30 | 2010-12-31 | Biohit Oyj | Pharmaceutical composition to reduce the risk of sunk in cancer by binding acetaldehyde in saliva, stomach and colon |
| JP5654726B2 (en) * | 2004-10-08 | 2015-01-14 | ビオヒット・ユルキネン・オサケユキテュアＢｉｏｈｉｔ Ｏｙｊ | Methods and formulations for binding aldehydes in saliva |
| FI122914B (en) * | 2005-04-01 | 2012-08-31 | Biohit Oyj | Food composition for binding of acetaldehyde in the mouth and in the digestive tract and process for the preparation of the composition |
| FI20070705L (en) * | 2007-09-14 | 2009-06-02 | Biohit Oyj | Binding of acetaldehyde in the mouth and in the stomach |
| US20090197956A1 (en) * | 2008-02-04 | 2009-08-06 | Arbor Pharmaceuticals, Inc. | Treatment of acute otitis media with xylitol and n-acetylcysteine |
| FI20115377A (en) * | 2011-04-18 | 2012-10-19 | Biohit Oyj | Medical products for use in conditions related to microbial infections of upper respiratory and digestive organs |
| FI20115680L (en) * | 2011-06-29 | 2012-12-30 | Biohit Oyj | Liquid pharmaceutical compositions or combination products |
-
2013
- 2013-02-01 FI FI20135097A patent/FI20135097L/en not_active IP Right Cessation
-
2014
- 2014-01-31 EA EA201591203A patent/EA201591203A1/en unknown
- 2014-01-31 EP EP14746925.8A patent/EP2950794A4/en not_active Withdrawn
- 2014-01-31 CN CN201810750529.3A patent/CN108969500A/en active Pending
- 2014-01-31 CN CN201480007086.9A patent/CN105307649A/en active Pending
- 2014-01-31 WO PCT/FI2014/050076 patent/WO2014118438A1/en active Application Filing
- 2014-01-31 MX MX2015009972A patent/MX2015009972A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN105307649A (en) | 2016-02-03 |
| EP2950794A4 (en) | 2016-11-09 |
| MX2015009972A (en) | 2016-03-11 |
| EP2950794A1 (en) | 2015-12-09 |
| CN108969500A (en) | 2018-12-11 |
| FI20135097L (en) | 2014-08-02 |
| WO2014118438A1 (en) | 2014-08-07 |
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