EA201500493A1 - A METHOD FOR DETERMINING THE INDICATOR OF THE EFFICIENCY OF PHOTOTHERAPE IMPACT AT THE BELLS OF THE NEWBORN - Google Patents
A METHOD FOR DETERMINING THE INDICATOR OF THE EFFICIENCY OF PHOTOTHERAPE IMPACT AT THE BELLS OF THE NEWBORNInfo
- Publication number
- EA201500493A1 EA201500493A1 EA201500493A EA201500493A EA201500493A1 EA 201500493 A1 EA201500493 A1 EA 201500493A1 EA 201500493 A EA201500493 A EA 201500493A EA 201500493 A EA201500493 A EA 201500493A EA 201500493 A1 EA201500493 A1 EA 201500493A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- skin
- radiation
- bilirubin
- phototherapy
- newborn
- Prior art date
Links
Abstract
Предлагаемое изобретение относится к области медицины, в частности к области неонатологии, и может быть использовано при проведении фототерапевтического лечения желтухи новорожденных. Направлено на решение задачи непосредственно определения скорости фотоизомеризации билирубина в любой момент времени при фототерапии неонатальной желтухи. Поставленная задача достигается тем, что устанавливают спектральную характеристику источника фототерапевтического излучения D(λ), в любой момент фототерапии измеряют спектр диффузного отражения света от кожи новорожденного, путем минимизации невязки между спектрами диффузного отражения кожи, измеренным и рассчитанным в рамках модели переноса излучения в коже, определяют оптические и геометрические параметры кожи, влияющие на перенос в ней излучения, рассчитывают распределение плотности излучения E(z, λ) по глубине кожи z в спектральном диапазоне фототерапевтического воздействия [λ, λ] при единичной освещенности поверхности кожи в соответствии с определенными для нее оптическими и геометрическими параметрами, а скорость трансформации токсичного ZZ-билирубина в нетоксичный и водорастворимый фотоизомер люмирубин LR определяют на основе выражениягде εи ε(см/мкМ) - молярные коэффициенты поглощения фотоизомеров билирубина ZZ и ZE; φ, φ, φ- квантовые выходы процессов фотоизомеризации ZZ → ZE, ZE → ZZ, и ZZ → LR соответственно, h = 6.63∙10Дж∙с - постоянная пПланка, с = 3-10см/с - скорость света, Nμ = 6.02∙10моль- число Авогадро, Lи L- геометрические толщины эпидермиса и дермы, z= L, z= L+ L.The present invention relates to the field of medicine, in particular to the field of neonatology, and can be used when conducting phototherapeutic treatment of neonatal jaundice. Aimed at solving the problem of directly determining the rate of photoisomerization of bilirubin at any time during phototherapy of neonatal jaundice. The task is achieved by establishing the spectral characteristic of the source of phototherapeutic radiation D (λ), at any time phototherapy measure the diffuse reflection of light from the skin of the newborn, by minimizing the discrepancy between the diffuse reflection spectra of the skin, measured and calculated in the model of radiation transfer in the skin, determine the optical and geometric parameters of the skin, affecting the transfer of radiation in it, calculate the distribution of radiation density E (z, λ) over the depth of the skin z in the spectral the range of phototherapy effects [λ, λ] with a single illumination of the skin surface in accordance with the optical and geometric parameters determined for it, and the rate of transformation of toxic ZZ-bilirubin into a non-toxic and water-soluble photoisomer Lumirubin LR is determined on the basis of the expression ε and ε (cm / μM) - molar absorption coefficients of the photo isomers of bilirubin ZZ and ZE; φ, φ, φ - quantum outputs of photoisomerization processes ZZ → ZE, ZE → ZZ, and ZZ → LR, respectively, h = 6.63 10J ∙ s - constant p Plank, c = 3-10cm / s - speed of light, Nμ = 6.02 10 mol is Avogadro's number, L and L are the geometric thicknesses of the epidermis and dermis, z = L, z = L + L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EA201500493A EA031413B1 (en) | 2015-04-16 | 2015-04-16 | Method for determination of toxic bilirubin transformation speed into non-toxic, and water-soluble photoisomer lumirubin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EA201500493A EA031413B1 (en) | 2015-04-16 | 2015-04-16 | Method for determination of toxic bilirubin transformation speed into non-toxic, and water-soluble photoisomer lumirubin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201500493A1 true EA201500493A1 (en) | 2016-10-31 |
| EA031413B1 EA031413B1 (en) | 2018-12-28 |
Family
ID=57189653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201500493A EA031413B1 (en) | 2015-04-16 | 2015-04-16 | Method for determination of toxic bilirubin transformation speed into non-toxic, and water-soluble photoisomer lumirubin |
Country Status (1)
| Country | Link |
|---|---|
| EA (1) | EA031413B1 (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5353790A (en) * | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
| RU2054181C1 (en) * | 1993-07-30 | 1996-02-10 | Акционерное общество закрытого типа "Научно-производственное предприятие "Техномедика" | Method for determining effectiveness index of phototherapeutic treatment in cases of neonatal jaundice |
| US6353226B1 (en) * | 1998-11-23 | 2002-03-05 | Abbott Laboratories | Non-invasive sensor capable of determining optical parameters in a sample having multiple layers |
| RU2511747C2 (en) * | 2012-03-07 | 2014-04-10 | Белорусский Государственный Университет (Бгу) | Method for determining bilirubin concentration |
| RU2506567C1 (en) * | 2012-08-01 | 2014-02-10 | Белорусский Государственный Университет (Бгу) | Method to determine concentrations of biological tissue chromophores |
-
2015
- 2015-04-16 EA EA201500493A patent/EA031413B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EA031413B1 (en) | 2018-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Valentine et al. | Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas | |
| Carroll et al. | Developments in low level light therapy (LLLT) for dentistry | |
| Valentine et al. | Modelling fluorescence in clinical photodynamic therapy | |
| Liu et al. | A dynamic model for ALA-PDT of skin: simulation of temporal and spatial distributions of ground-state oxygen, photosensitizer and singlet oxygen | |
| Karsten et al. | Modeling and verification of melanin concentration on human skin type | |
| Valentine et al. | Monte Carlo simulations for optimal light delivery in photodynamic therapy of non-melanoma skin cancer | |
| Ong et al. | PDT dose dosimetry for Photofrin-mediated pleural photodynamic therapy (pPDT) | |
| TWI374763B (en) | Hair growth light management device | |
| Kim et al. | Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy | |
| RU2012139381A (en) | METHOD FOR PHOTODYNAMIC TREATMENT OF TUMOR | |
| Liu et al. | Comparison of photodynamic therapy with different excitation wavelengths using a dynamic model of aminolevulinic acid-photodynamic therapy of human skin | |
| Atif et al. | Optical properties of normal and thermally coagulated chicken liver tissue measured ex-vivo with diffuse reflectance | |
| Campbell et al. | Monte Carlo modelling of daylight activated photodynamic therapy | |
| Liu et al. | Comparison of noninvasive photodynamic therapy dosimetry methods using a dynamic model of ALA-PDT of human skin | |
| SE0900552L (en) | Device for concentration measurement of constituents in blood and measurement method | |
| EA201500493A1 (en) | A METHOD FOR DETERMINING THE INDICATOR OF THE EFFICIENCY OF PHOTOTHERAPE IMPACT AT THE BELLS OF THE NEWBORN | |
| de Souza et al. | Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ | |
| Ruiz et al. | Effective fluence and dose at skin depth of daylight and lamp sources for PpIX-based photodynamic therapy | |
| Vicentini et al. | Photodynamic therapy for actinic keratosis of the forehead and scalp with the Aktilite CL 128: Is there a cut‐off value for Pp IX‐weighted irradiance for effective treatment? | |
| Nielsen et al. | Retrieval of the physiological state of human skin from UV–Vis reflectance spectra–a feasibility study | |
| Li et al. | Advanced optical techniques for monitoring dosimetric parameters in photodynamic therapy | |
| Lisenko et al. | Method for estimating bilirubin isomerization efficiency in phototherapy to treat neonatal jaundice | |
| Zhu | Dosimetry in pleural photodynamic therapy | |
| Eugenia et al. | Photodynamic therapy in fibrosarcoma BALB/c animal model: Observation of the rebound effect | |
| RU2012108901A (en) | METHOD FOR DETERMINING BILIRUBIN CONCENTRATION |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |