EA201490960A1 - COMPOSITION 4-METHYL-3 - [[4- (3-PYRIDINIL) -2-PYRIMIDINYL] AMINO] -N- [5- (4-METHYL-1H-IMIDAZOL-1-IL) -3- (TRIFTOROMETYL) FENYL] BENZAMIDE WITH IMMEDIATE DELIVERY - Google Patents

COMPOSITION 4-METHYL-3 - [[4- (3-PYRIDINIL) -2-PYRIMIDINYL] AMINO] -N- [5- (4-METHYL-1H-IMIDAZOL-1-IL) -3- (TRIFTOROMETYL) FENYL] BENZAMIDE WITH IMMEDIATE DELIVERY

Info

Publication number
EA201490960A1
EA201490960A1 EA201490960A EA201490960A EA201490960A1 EA 201490960 A1 EA201490960 A1 EA 201490960A1 EA 201490960 A EA201490960 A EA 201490960A EA 201490960 A EA201490960 A EA 201490960A EA 201490960 A1 EA201490960 A1 EA 201490960A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methyl
benzamide
imidazol
pyrimidinyl
amino
Prior art date
Application number
EA201490960A
Other languages
Russian (ru)
Inventor
Упкар Бхардвадж
Мангеш Садашив Бордавекар
Энн Риз Комфорт
Пин Ли
Шоуфэн Ли
Алексей Макаров
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201490960A1 publication Critical patent/EA201490960A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

Описана твердая дозированная форма нилотиниба, которая содержит: (i) сердцевину, содержащую 4-метил-3-[[4-(3-пиридинил)-2-пиримидинил]амино]-N-[5-(4-метил-1Н-имидазол-1-ил)-3-(трифторметил)фенил]бензамид или его фармацевтически приемлемую соль и эксципиенты; и (ii) по меньшей мере один полимер, указанный полимер покрывает указанную сердцевину, где распад указанной твердой дозированной формы отсрочен.A solid dosage form of nilotinib is described which contains: (i) a core containing 4-methyl-3 - [[4- (3-pyridinyl) -2-pyrimidinyl] amino] -N- [5- (4-methyl-1H- imidazol-1-yl) -3- (trifluoromethyl) phenyl] benzamide or its pharmaceutically acceptable salt and excipients; and (ii) at least one polymer, said polymer coating said core, where the decay of said solid dosage form is delayed.

EA201490960A 2011-11-14 2012-11-12 COMPOSITION 4-METHYL-3 - [[4- (3-PYRIDINIL) -2-PYRIMIDINYL] AMINO] -N- [5- (4-METHYL-1H-IMIDAZOL-1-IL) -3- (TRIFTOROMETYL) FENYL] BENZAMIDE WITH IMMEDIATE DELIVERY EA201490960A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161559281P 2011-11-14 2011-11-14
PCT/US2012/064610 WO2013074432A1 (en) 2011-11-14 2012-11-12 Immediate release 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-[5-(4-methyl- 1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide formulation

Publications (1)

Publication Number Publication Date
EA201490960A1 true EA201490960A1 (en) 2014-08-29

Family

ID=47324402

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490960A EA201490960A1 (en) 2011-11-14 2012-11-12 COMPOSITION 4-METHYL-3 - [[4- (3-PYRIDINIL) -2-PYRIMIDINYL] AMINO] -N- [5- (4-METHYL-1H-IMIDAZOL-1-IL) -3- (TRIFTOROMETYL) FENYL] BENZAMIDE WITH IMMEDIATE DELIVERY

Country Status (22)

Country Link
EP (1) EP2779995A1 (en)
JP (1) JP6275645B2 (en)
KR (1) KR20140093230A (en)
CN (1) CN103930094A (en)
AR (1) AR088844A1 (en)
BR (1) BR112014011518A2 (en)
CA (1) CA2855503A1 (en)
CL (1) CL2014001247A1 (en)
CO (1) CO6960546A2 (en)
EA (1) EA201490960A1 (en)
GT (1) GT201400094A (en)
HK (1) HK1197025A1 (en)
IL (1) IL232480A0 (en)
IN (1) IN2014DN03416A (en)
MA (1) MA35636B1 (en)
MX (1) MX2014005874A (en)
PE (1) PE20141337A1 (en)
SG (2) SG10201707768RA (en)
TN (1) TN2014000177A1 (en)
TW (1) TWI574690B (en)
WO (1) WO2013074432A1 (en)
ZA (1) ZA201402756B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
CZ2017821A3 (en) 2017-12-20 2019-07-03 Zentiva, K.S. Dosing of crystalline nilotinib
JP7378279B2 (en) 2019-11-18 2023-11-13 日本化薬株式会社 Pharmaceutical tablet containing nilotinib as an active ingredient and method for producing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GT200600315A (en) 2005-07-20 2007-03-19 CRYSTAL FORMS OF 4-METHYL-N- [3- (4-METHYL-IMIDAZOL-1-ILO) -5-TRIFLUOROMETILO-PHENYL] -3- (4-PYRIDINA-3-ILO-PIRIMIDINA-2-ILOAMINO) -BENZAMIDA
GT200600316A (en) 2005-07-20 2007-04-02 SALTS OF 4-METHYL-N- (3- (4-METHYL-IMIDAZOL-1-ILO) -5-TRIFLUOROMETILO-PHENYL) -3- (4-PIRIDINA-3-ILO-PIRIMIDINA-2-ILOAMINO) - BENZAMIDA.
EP1923053A1 (en) * 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
IN2011CH01887A (en) * 2011-06-02 2012-12-14

Also Published As

Publication number Publication date
PE20141337A1 (en) 2014-10-16
KR20140093230A (en) 2014-07-25
IN2014DN03416A (en) 2015-06-26
AR088844A1 (en) 2014-07-10
IL232480A0 (en) 2014-06-30
SG11201401476TA (en) 2014-10-30
MA35636B1 (en) 2014-11-01
CL2014001247A1 (en) 2014-10-17
SG10201707768RA (en) 2017-10-30
CO6960546A2 (en) 2014-05-30
AU2012339829B2 (en) 2016-05-12
GT201400094A (en) 2017-09-28
AU2012339829A1 (en) 2014-05-29
CA2855503A1 (en) 2013-05-23
ZA201402756B (en) 2015-04-29
MX2014005874A (en) 2014-06-23
TN2014000177A1 (en) 2015-09-30
NZ623844A (en) 2016-09-30
JP2014533283A (en) 2014-12-11
TW201325594A (en) 2013-07-01
WO2013074432A1 (en) 2013-05-23
HK1197025A1 (en) 2015-01-02
EP2779995A1 (en) 2014-09-24
TWI574690B (en) 2017-03-21
BR112014011518A2 (en) 2017-05-16
CN103930094A (en) 2014-07-16
JP6275645B2 (en) 2018-02-07

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