EA201490621A1 - INDANINE-SUBSTITUTE 4,5,6,7-TETRAGIDRO-1H-PYRAZOLO [4,3-C] Pyridine, THEIR APPLICATION AS A MEDICINE AND CONTAINING THEIR PHARMACEUTICAL PREPARATIONS - Google Patents

INDANINE-SUBSTITUTE 4,5,6,7-TETRAGIDRO-1H-PYRAZOLO [4,3-C] Pyridine, THEIR APPLICATION AS A MEDICINE AND CONTAINING THEIR PHARMACEUTICAL PREPARATIONS

Info

Publication number
EA201490621A1
EA201490621A1 EA201490621A EA201490621A EA201490621A1 EA 201490621 A1 EA201490621 A1 EA 201490621A1 EA 201490621 A EA201490621 A EA 201490621A EA 201490621 A EA201490621 A EA 201490621A EA 201490621 A1 EA201490621 A1 EA 201490621A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazolo
medicine
pharmaceutical preparations
tetragidro
indanine
Prior art date
Application number
EA201490621A
Other languages
Russian (ru)
Other versions
EA023648B1 (en
Inventor
Лоран Биали
Йозеф Пернершторфер
Клаус Вирт
Клаус Стайнмайер
Герхард Хесслер
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи filed Critical Санофи
Publication of EA201490621A1 publication Critical patent/EA201490621A1/en
Publication of EA023648B1 publication Critical patent/EA023648B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

Изобретение относится к замещенным 4,5,6,7-тетрагидро-1Н-пиразоло[4,3-c]пиридинам формулы I, их применению в качестве лекарственного средства и содержащим их фармацевтическим препаратам.Соединения формулы I оказывают воздействие на калиевый канал TASK-1. Соединения пригодны для лечения или профилактики предсердной аритмии, например фибрилляции предсердий (ФП) или трепетания предсердий.The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo [4,3-c] pyridines of the formula I, their use as a medicine and pharmaceutical preparations containing them. Compounds of the formula I affect the potassium channel TASK- 1. The compounds are suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.

EA201490621A 2011-09-12 2012-09-10 NDANYL-SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM EA023648B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11306129 2011-09-12
PCT/EP2012/067654 WO2013037736A1 (en) 2011-09-12 2012-09-10 Indanyl-substituted 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them

Publications (2)

Publication Number Publication Date
EA201490621A1 true EA201490621A1 (en) 2014-08-29
EA023648B1 EA023648B1 (en) 2016-06-30

Family

ID=46829768

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490621A EA023648B1 (en) 2011-09-12 2012-09-10 NDANYL-SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM

Country Status (4)

Country Link
BR (1) BR112014005583A2 (en)
EA (1) EA023648B1 (en)
MX (1) MX2014002968A (en)
WO (1) WO2013037736A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3386993A1 (en) 2015-12-10 2018-10-17 Bayer Pharma Aktiengesellschaft Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same
GEP20207104B (en) 2015-12-10 2020-05-11 Bayer Pharma AG 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
JOP20190284A1 (en) 2017-06-14 2019-12-11 Bayer Pharma AG Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK27383A (en) * 1982-02-17 1983-08-18 Lepetit Spa PROCEDURE FOR PREPARING PYRAZOLE (4,3-C) PYRIDINES
DE10332685A1 (en) 2003-07-18 2005-02-17 Bayer Healthcare Ag Use of a modulator of specific potassium channels, expressed preferentially in the atrium, for treatment and prevention of arrhythmia, coronary disease and hypertension
DE102005028862A1 (en) 2005-06-22 2007-01-11 Sanofi-Aventis Deutschland Gmbh Substituted heterocycles, their use as medicament and pharmaceutical compositions containing them
NZ572231A (en) * 2006-04-27 2010-12-24 Sanofi Aventis Deutschland Inhibitors of the task-1 and task-3 ion channel
CA2735842A1 (en) 2008-09-02 2010-03-11 Sanofi-Aventis Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof

Also Published As

Publication number Publication date
MX2014002968A (en) 2014-07-09
EA023648B1 (en) 2016-06-30
BR112014005583A2 (en) 2017-03-21
WO2013037736A1 (en) 2013-03-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU