EA201490640A1 - SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO [4,3-C] Pyridine, THEIR APPLICATION AS A MEDICINE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM - Google Patents

SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO [4,3-C] Pyridine, THEIR APPLICATION AS A MEDICINE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

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Publication number
EA201490640A1
EA201490640A1 EA201490640A EA201490640A EA201490640A1 EA 201490640 A1 EA201490640 A1 EA 201490640A1 EA 201490640 A EA201490640 A EA 201490640A EA 201490640 A EA201490640 A EA 201490640A EA 201490640 A1 EA201490640 A1 EA 201490640A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazolo
tetrahydro
medicine
substituted
pharmaceutical preparations
Prior art date
Application number
EA201490640A
Other languages
Russian (ru)
Other versions
EA025240B1 (en
Inventor
Лоран Биали
Катрин Лоренц
Клаус Вирт
Клаус Штайнмейер
Герхард Хесслер
Йозеф Пернершторфер
Йоахим Брендель
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи filed Critical Санофи
Publication of EA201490640A1 publication Critical patent/EA201490640A1/en
Publication of EA025240B1 publication Critical patent/EA025240B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к замещенным 4,5,6,7-тетрагидро-1Н-пиразоло[4,3-c]пиридинам формулы (I), их применению в качестве лекарственного средства и содержащим их фармацевтическим препаратам. Соединения формулы (I) действуют на калиевый канал TASK-1. Соединения подходят для лечения или предупреждения предсердных аритмий, например предсердной фибрилляции (ПФ) или предсердного трепетания.The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo [4,3-c] pyridines of the formula (I), their use as a medicine and pharmaceutical preparations containing them. The compounds of formula (I) act on the potassium channel TASK-1. The compounds are suitable for treating or preventing atrial arrhythmias, for example, atrial fibrillation (PF) or atrial flutter.

EA201490640A 2011-09-16 2012-09-13 SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM EA025240B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11306161 2011-09-16
PCT/EP2012/067995 WO2013037914A1 (en) 2011-09-16 2012-09-13 Substituted 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them

Publications (2)

Publication Number Publication Date
EA201490640A1 true EA201490640A1 (en) 2014-09-30
EA025240B1 EA025240B1 (en) 2016-12-30

Family

ID=46832425

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490640A EA025240B1 (en) 2011-09-16 2012-09-13 SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM

Country Status (4)

Country Link
BR (1) BR112014006180A2 (en)
EA (1) EA025240B1 (en)
MX (1) MX2014003181A (en)
WO (1) WO2013037914A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9708334B2 (en) * 2014-04-24 2017-07-18 Dart Neuroscience (Cayman) Ltd. Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine compounds as GlyT1 inhibitors
EP3215500A1 (en) 2014-11-05 2017-09-13 Dart NeuroScience (Cayman) Ltd. Substituted azetidinyl compounds as glyt1 inhibitors
AU2015373996B2 (en) * 2014-12-30 2020-10-08 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis B infections
EP3386993A1 (en) 2015-12-10 2018-10-17 Bayer Pharma Aktiengesellschaft Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same
GEP20207104B (en) * 2015-12-10 2020-05-11 Bayer Pharma AG 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
JOP20190284A1 (en) * 2017-06-14 2019-12-11 Bayer Pharma AG Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
WO2021207308A1 (en) * 2020-04-09 2021-10-14 Disarm Therapeutics, Inc. Condensed pyrazole derivatives as inhibitors of sarm1
GB202101734D0 (en) * 2021-02-08 2021-03-24 Cerevance Inc Novel Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK27383A (en) * 1982-02-17 1983-08-18 Lepetit Spa PROCEDURE FOR PREPARING PYRAZOLE (4,3-C) PYRIDINES
DE10332685A1 (en) 2003-07-18 2005-02-17 Bayer Healthcare Ag Use of a modulator of specific potassium channels, expressed preferentially in the atrium, for treatment and prevention of arrhythmia, coronary disease and hypertension
DE102005028862A1 (en) 2005-06-22 2007-01-11 Sanofi-Aventis Deutschland Gmbh Substituted heterocycles, their use as medicament and pharmaceutical compositions containing them
DE102005028845A1 (en) * 2005-06-22 2006-12-28 Sanofi-Aventis Deutschland Gmbh New substituted pyrrolidin-2-ones, piperidin-2-ones and isothiazolidine-1,1-dioxides useful for treating e.g. dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, breast cancer and heart failure
NZ572231A (en) 2006-04-27 2010-12-24 Sanofi Aventis Deutschland Inhibitors of the task-1 and task-3 ion channel
WO2011115804A1 (en) * 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators

Also Published As

Publication number Publication date
WO2013037914A1 (en) 2013-03-21
EA025240B1 (en) 2016-12-30
BR112014006180A2 (en) 2017-04-11
MX2014003181A (en) 2015-08-05

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU