EA201400187A1 - Способ получения ивабрадина и промежуточных продуктов его синтеза - Google Patents

Способ получения ивабрадина и промежуточных продуктов его синтеза

Info

Publication number
EA201400187A1
EA201400187A1 EA201400187A EA201400187A EA201400187A1 EA 201400187 A1 EA201400187 A1 EA 201400187A1 EA 201400187 A EA201400187 A EA 201400187A EA 201400187 A EA201400187 A EA 201400187A EA 201400187 A1 EA201400187 A1 EA 201400187A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
ivabradin
obtaining
intermediate products
products
Prior art date
Application number
EA201400187A
Other languages
English (en)
Other versions
EA026170B1 (ru
Inventor
Антонио Нарди
Бруно Де Анджелис
Паоланджело Череа
Джейн Льоренс Рафекас
Николя Тессон
Original Assignee
Лабораторио Кимико Интернационале С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лабораторио Кимико Интернационале С.П.А. filed Critical Лабораторио Кимико Интернационале С.П.А.
Publication of EA201400187A1 publication Critical patent/EA201400187A1/ru
Publication of EA026170B1 publication Critical patent/EA026170B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/46—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acids or esters thereof in presence of ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/04—Mono-, di- or tri-methylamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к новому способу разделения ивабрадина и промежуточных продуктов его синтеза.
EA201400187A 2011-08-01 2012-07-31 Способ получения ивабрадина и промежуточных продуктов его синтеза EA026170B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001467A ITMI20111467A1 (it) 2011-08-01 2011-08-01 Procedimento per la preparazione di ivabradina e di suoi intermedi di sintesi
PCT/IB2012/001477 WO2013017937A1 (en) 2011-08-01 2012-07-31 Process for the manufacture of ivabradine and of intermediates of synthesis thereof

Publications (2)

Publication Number Publication Date
EA201400187A1 true EA201400187A1 (ru) 2014-11-28
EA026170B1 EA026170B1 (ru) 2017-03-31

Family

ID=44720966

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400187A EA026170B1 (ru) 2011-08-01 2012-07-31 Способ получения ивабрадина и промежуточных продуктов его синтеза

Country Status (15)

Country Link
US (1) US9006424B2 (ru)
EP (1) EP2739610B1 (ru)
CN (1) CN103781767B (ru)
BR (1) BR112014002522A2 (ru)
CA (1) CA2843553A1 (ru)
CY (1) CY1118121T1 (ru)
EA (1) EA026170B1 (ru)
ES (1) ES2582673T3 (ru)
HR (1) HRP20160766T1 (ru)
HU (1) HUE029760T2 (ru)
IT (1) ITMI20111467A1 (ru)
PL (1) PL2739610T3 (ru)
PT (1) PT2739610T (ru)
SI (1) SI2739610T1 (ru)
WO (1) WO2013017937A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP1935872A1 (en) * 2006-12-11 2008-06-25 Stirling Products Limited Process for obtaining the R-enantiomer of salbutamol
CN101434552B (zh) * 2007-11-16 2012-05-23 江苏恒瑞医药股份有限公司 4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的拆分
CN102264689B (zh) * 2008-12-22 2014-12-31 新梅斯托克尔卡公司 制备伊伐布雷定的方法

Also Published As

Publication number Publication date
BR112014002522A2 (pt) 2017-02-21
PT2739610T (pt) 2016-07-19
CN103781767B (zh) 2016-02-03
EP2739610A1 (en) 2014-06-11
CY1118121T1 (el) 2017-06-28
SI2739610T1 (sl) 2016-08-31
PL2739610T3 (pl) 2016-11-30
US20140357859A1 (en) 2014-12-04
EP2739610B1 (en) 2016-04-27
US9006424B2 (en) 2015-04-14
ES2582673T3 (es) 2016-09-14
WO2013017937A8 (en) 2014-02-27
CA2843553A1 (en) 2013-02-07
HRP20160766T1 (hr) 2016-08-12
CN103781767A (zh) 2014-05-07
EA026170B1 (ru) 2017-03-31
WO2013017937A1 (en) 2013-02-07
HUE029760T2 (en) 2017-04-28
ITMI20111467A1 (it) 2013-02-02

Similar Documents

Publication Publication Date Title
CY1123958T1 (el) Μεθοδος παρασκευης παραγωγων και ενδιαμεσων καρβαμοϋλπυριδονης
CY1121862T1 (el) Αντισωματα anti-phf-tau και χρησεις αυτων
SMT201600375B (it) Procedimento per la produzione di estetrolo
DK2736837T3 (da) Fremgangsmåde til fremstilling af nanosiliciumtråde
EP2938616A4 (en) PROCESS FOR THE PREPARATION OF TOFACITINIB AND INTERMEDIATES
UA110813C2 (uk) Лікування ліподистрофії
BR112014003878A2 (pt) síntese de r-bifenilalaninol
MY163339A (en) A method of producing ingenol-3-angelate
DK2552562T3 (da) Separationsproces
ZA201501372B (en) Production of soluble protein products from hemp ("h701")
BR112013033149A2 (pt) peça de vestuário e método de sua produção
EP2691396A4 (en) ENOPEPTINES, USES THEREOF, AND METHODS OF SYNTHESIZING THE SAME
IL229742A0 (en) Hyperforin analogues, methods for their production and their uses
CL2012003371A1 (es) Compuestos intermediarios de la síntesis de agomelatina; y el procedimiento de obtención de agomelatina a partir de dichos compuestos intermediarios
EP2699532A4 (en) PREPARATION OF SATURATED HYDROCARBONS FROM A SYNTHESEGAS
PH12016501201A1 (en) Synthesis of ent-progesterone and intermediates thereof
MX2012010443A (es) Proceso para la preparacion de 1-alquiltetrazoles 5-sustituidos.
EA201400187A1 (ru) Способ получения ивабрадина и промежуточных продуктов его синтеза
MX2015012902A (es) Sintesis de ent-progesterona e intermediarios de la misma.
FR2987092B1 (fr) Ensemble de reducteurs.
MX354501B (es) Ingrediente perfumante de la familia galbano.
EA201291316A1 (ru) Чистка установок hf-алкилирования
MX2014002630A (es) Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
EA201400188A1 (ru) Способ получения кристаллической формы i агомелатина
DE102010026565A8 (de) Herstellverfahren von Lebensmittelzusatzstoffen

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU