EA201300280A1 - BIODRAINABLE POLYMERIC THREAD AND METHOD FOR OBTAINING IT - Google Patents

BIODRAINABLE POLYMERIC THREAD AND METHOD FOR OBTAINING IT

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Publication number
EA201300280A1
EA201300280A1 EA201300280A EA201300280A EA201300280A1 EA 201300280 A1 EA201300280 A1 EA 201300280A1 EA 201300280 A EA201300280 A EA 201300280A EA 201300280 A EA201300280 A EA 201300280A EA 201300280 A1 EA201300280 A1 EA 201300280A1
Authority
EA
Eurasian Patent Office
Prior art keywords
lactic acid
thread
glycolide
chitosan
copolymer
Prior art date
Application number
EA201300280A
Other languages
Russian (ru)
Other versions
EA022047B1 (en
Inventor
Дмитрий Валерьевич КАПУСТИН
Алла Николаевна Генералова
Анна Игоревна ПРОСТЯКОВА
Original Assignee
Общество с ограниченной ответственностью "БИОСТЭН"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общество с ограниченной ответственностью "БИОСТЭН" filed Critical Общество с ограниченной ответственностью "БИОСТЭН"
Priority to EA201300280A priority Critical patent/EA022047B1/en
Publication of EA201300280A1 publication Critical patent/EA201300280A1/en
Publication of EA022047B1 publication Critical patent/EA022047B1/en

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Abstract

Изобретение относится к области биотехнологии и медицины, а именно к технологии получения биоразлагаемых полимерных нитей, которые могут использоваться в производстве плетеных сосудистых стентов. Техническим результатом изобретения является применение биоразлагаемого полимерного материала в качестве основы монофиламентной нити с покрытием на базе хитозана для плетения сосудистых стентов при сохранении прочностных и упругих качеств, улучшение биосовместимости и прогнозирования скорости резорбции. Основу нити выполняют из гомополимера молочной кислоты или сополимера изомеров молочной кислоты с гликолидом путем формирования полимерной ленты толщиной 0,3-0,5 мм и шириной 2-4 мм многослойным напылением раствора гомополимера молочной кислоты или сополимера изомеров молочной кислоты с гликолидом в летучем растворителе на не адгезивную к материалу основы подложку. Ленту отделяют от подложки и растягивают в длину на 75-100% с одновременным закручиванием ее вокруг своей продольной оси. Основу покрывают хитозаном, сшитым генипином. Получают нить диаметром 0,15-0,55 мм со следующим составом, мас.%: основа - 80-99; покрытие - 1-20.The invention relates to the field of biotechnology and medicine, in particular to a technology for producing biodegradable polymer filaments, which can be used in the production of braided vascular stents. The technical result of the invention is the use of biodegradable polymeric material as the basis of monofilament yarn with a coating based on chitosan for weaving vascular stents while maintaining the strength and elastic properties, improving biocompatibility and prediction of resorption rate. The basis of the thread is made from a homopolymer of lactic acid or a copolymer of lactic acid isomers with glycolide by forming a polymer tape 0.3-0.5 mm thick and 2-4 mm wide by multilayer spraying of a solution of lactic acid homopolymer or a copolymer of lactic acid isomers with a glycolide in a volatile solvent on non-adhesive backing material. The tape is separated from the substrate and stretch in length by 75-100% with its simultaneous twisting around its longitudinal axis. The base is coated with chitosan, crosslinked with genipin. Get the thread with a diameter of 0.15-0.55 mm with the following composition, wt.%: Base - 80-99; coverage - 1-20.

EA201300280A 2013-03-26 2013-03-26 Biodegradable polymer thread and method for producing the same EA022047B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA201300280A EA022047B1 (en) 2013-03-26 2013-03-26 Biodegradable polymer thread and method for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201300280A EA022047B1 (en) 2013-03-26 2013-03-26 Biodegradable polymer thread and method for producing the same

Publications (2)

Publication Number Publication Date
EA201300280A1 true EA201300280A1 (en) 2014-09-30
EA022047B1 EA022047B1 (en) 2015-10-30

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ID=51628519

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300280A EA022047B1 (en) 2013-03-26 2013-03-26 Biodegradable polymer thread and method for producing the same

Country Status (1)

Country Link
EA (1) EA022047B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112516391A (en) * 2020-12-21 2021-03-19 辽宁垠艺生物科技股份有限公司 Drug loading method for stent with membrane

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162537A (en) * 1996-11-12 2000-12-19 Solutia Inc. Implantable fibers and medical articles
RU2408746C1 (en) * 2009-06-29 2011-01-10 Государственное образовательное учреждение высшего профессионального образования "Московский государственный текстильный университет имени А.Н. Косыгина" Method of producing chitosan-containing threads
RU115663U1 (en) * 2011-11-01 2012-05-10 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) BIODEGRADABLE SEAMED SURGICAL COATED SURGERY

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112516391A (en) * 2020-12-21 2021-03-19 辽宁垠艺生物科技股份有限公司 Drug loading method for stent with membrane

Also Published As

Publication number Publication date
EA022047B1 (en) 2015-10-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU