EA201201336A1 - Recombinant plasmid DNA pFK3, provides a synthesis of recombinant peptides RL3, is an analogue of kappa-casein FRAGMENTS OF HUMAN RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-BLUE / pFK3 and recombinant peptides RL3 - ANALOG FRAGMENTS of kappa-casein A person with apoptotic activity against cancer cells - Google Patents
Recombinant plasmid DNA pFK3, provides a synthesis of recombinant peptides RL3, is an analogue of kappa-casein FRAGMENTS OF HUMAN RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-BLUE / pFK3 and recombinant peptides RL3 - ANALOG FRAGMENTS of kappa-casein A person with apoptotic activity against cancer cellsInfo
- Publication number
- EA201201336A1 EA201201336A1 EA201201336A EA201201336A EA201201336A1 EA 201201336 A1 EA201201336 A1 EA 201201336A1 EA 201201336 A EA201201336 A EA 201201336A EA 201201336 A EA201201336 A EA 201201336A EA 201201336 A1 EA201201336 A1 EA 201201336A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- casein
- recombinant
- human
- kappa
- pfk3
- Prior art date
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к рекомбинантной плазмидной ДНК с фрагментами каппа-казеина человека, рекомбинантному штамму Escherichia coliпродуценту пептида - аналога каппа-казеина человека, обладающего апоптотической активностью по отношению к опухолевым клеткам и рекомбинантному пептиду - аналогу каппа-казеина человека и может быть использовано в биотехнологии. Рекомбинантная плазмидная ДНК pFK3 обеспечивает более высокий синтез рекомбинантного пептида RL3, являющегося аналогом фрагмента каппа-казеина человека и имеет молекулярную массу 2,41 MDa и размер 3647 п.о. Рекомбинантный штамм бактерий Escherichia coliXL1-Blue/pFK3 депонирован в Межинститутском Центре коллективного пользования СО РАН "Коллекция экстремофильных микроорганизмов и типовых культур" под № ЭМТК 1346 и является продуцентом пептида RL3 - аналога фрагмента каппа-казеина человека, обладающего апоптотической активностью по отношению к раковым клеткам. Кроме того, получен рекомбинантный пептид RL3 - аналог фрагмента каппа-казеина человека, имеющий молекулярную массу около 10 кДа, состоящий из остатка метионина, фрагмента каппа-казеина человека с 31 по 102 аминокислотный остаток и С-концевого гистидинового тракта и обладающий апоптотической активностью по отношению к раковым клеткам.The invention relates to recombinant plasmid DNA with fragments of human kappa-casein, a recombinant Escherichia coli strain of the peptide analogue of human kappa-casein, which has apoptotic activity against tumor cells and the recombinant peptide, an analogue of human kappa-casein, and can be used in biotechnology. Recombinant plasmid DNA pFK3 provides a higher synthesis of recombinant peptide RL3, which is an analogue of the human kappa-casein fragment and has a molecular weight of 2.41 MDa and a size of 3647 bp. The Escherichia coliXL1-Blue / pFK3 recombinant bacterial strain was deposited at the Inter-Institute Center for Collective Use of the Siberian Branch of the Russian Academy of Sciences "Collection of Extremophilic Microorganisms and Type Cultures" under No. EMTC 1346 and is a producer of peptide RL3, an analogue of human kappa-casein, having a human activity with a human subject, having a human activity, a human having an optically active band, RL3 peptide, an individual with a human activity, having a human subject with an apoptotic profile. . In addition, the obtained recombinant peptide RL3 is an analogue of the human kappa-casein fragment, having a molecular weight of about 10 kDa, consisting of a methionine residue, a human kappa-casein fragment with 31 to 102 amino acid residue and a C-terminal histidine tract and having apoptotic activity with respect to to cancer cells.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201201336A EA023387B1 (en) | 2012-10-08 | 2012-10-08 | RECOMBINANT PLASMID DNA pFK3, PROVIDING SYNTHESIS OF RECOMBINANT PEPTIDE RL3, WHICH IS ANALOGUE OF HUMAN KAPPA CASEIN FRAGMENT, RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-Blue/pFK3 AND RECOMBINANT PEPTIDE RL3, ANALOGUE OF HUMAN KAPPA CASEIN FRAGMENT, POSSESSING APOPTOTIC ACTIVITY WITH RESPECT TO CANCER CELLS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201201336A EA023387B1 (en) | 2012-10-08 | 2012-10-08 | RECOMBINANT PLASMID DNA pFK3, PROVIDING SYNTHESIS OF RECOMBINANT PEPTIDE RL3, WHICH IS ANALOGUE OF HUMAN KAPPA CASEIN FRAGMENT, RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-Blue/pFK3 AND RECOMBINANT PEPTIDE RL3, ANALOGUE OF HUMAN KAPPA CASEIN FRAGMENT, POSSESSING APOPTOTIC ACTIVITY WITH RESPECT TO CANCER CELLS |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201201336A1 true EA201201336A1 (en) | 2014-04-30 |
EA023387B1 EA023387B1 (en) | 2016-05-31 |
Family
ID=50516430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201201336A EA023387B1 (en) | 2012-10-08 | 2012-10-08 | RECOMBINANT PLASMID DNA pFK3, PROVIDING SYNTHESIS OF RECOMBINANT PEPTIDE RL3, WHICH IS ANALOGUE OF HUMAN KAPPA CASEIN FRAGMENT, RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-Blue/pFK3 AND RECOMBINANT PEPTIDE RL3, ANALOGUE OF HUMAN KAPPA CASEIN FRAGMENT, POSSESSING APOPTOTIC ACTIVITY WITH RESPECT TO CANCER CELLS |
Country Status (1)
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EA (1) | EA023387B1 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK8892D0 (en) * | 1992-01-23 | 1992-01-23 | Symbicom Ab | HUMANT PROTEING |
RU2317304C1 (en) * | 2006-04-17 | 2008-02-20 | Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (СО РАН) | Peptide possessing apoptotic activity with respect to human cancer cells |
RU2401307C1 (en) * | 2009-05-15 | 2010-10-10 | Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) | RECOMBINANT PLASMID DNA pFK2 PROVIDING SYNTHESIS OF RECOMBINANT PEPTIDE BEING HUMAN KAPPA CASEIN FRAGMENT ANALOGUE, METHOD FOR PREPARING RECOMBINANT PEPTIDE, AND RECOMBINANT PEPTIDE, HUMAN KAPPA CASEIN FRAGMENT ANALOGUE EXHIBITING APOPTOTIC ACTIVITY IN RELATION TO MALIGNANT CELLS |
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2012
- 2012-10-08 EA EA201201336A patent/EA023387B1/en not_active IP Right Cessation
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Publication number | Publication date |
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EA023387B1 (en) | 2016-05-31 |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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