EA201201337A1 - Recombinant plasmid DNA pFK4, provides a synthesis of recombinant peptide RL4, is an analogue of kappa-casein FRAGMENTS OF HUMAN RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-BLUE / pFK4 and recombinant peptide RL4 - ANALOG FRAGMENTS of kappa-casein A person with apoptotic activity against cancer cells - Google Patents
Recombinant plasmid DNA pFK4, provides a synthesis of recombinant peptide RL4, is an analogue of kappa-casein FRAGMENTS OF HUMAN RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-BLUE / pFK4 and recombinant peptide RL4 - ANALOG FRAGMENTS of kappa-casein A person with apoptotic activity against cancer cellsInfo
- Publication number
- EA201201337A1 EA201201337A1 EA201201337A EA201201337A EA201201337A1 EA 201201337 A1 EA201201337 A1 EA 201201337A1 EA 201201337 A EA201201337 A EA 201201337A EA 201201337 A EA201201337 A EA 201201337A EA 201201337 A1 EA201201337 A1 EA 201201337A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- casein
- recombinant
- human
- peptide
- kappa
- Prior art date
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Изобретение относится к рекомбинантной плазмидной ДНК с фрагментами каппа-казеина человека, рекомбинантному штамму Escherichia coli- продуценту пептида - аналога каппа-казеина человека, обладающего апоптотической активностью по отношению к опухолевым клеткам, и рекомбинантному пептиду - аналогу каппа-казеина человека, обладающему апоптотической активностью по отношению к опухолевым клеткам, и может быть использовано в биотехнологии. Рекомбинантная плазмидная ДНК pFK4 обеспечивает более высокий синтез рекомбинантного пептида RL4, являющегося аналогом фрагмента каппа-казеина человека, имеет молекулярную массу 2,41 MDa и размер 3653 п.о. Рекомбинантный штамм бактерий Escherichia coliXL1-Blue/pFK4 депонирован в Межинститутском Центре коллективного пользования СО РАН "Коллекция экстремофильных микроорганизмов и типовых культур" ИХБФМ СО РАН под № ЭМТК 1347 и является продуцентом пептида RL4 - аналога фрагмента каппа-казеина человека, обладающего апоптотической активностью по отношению к раковым клеткам. Получен рекомбинантный пептид RL4 - аналог фрагмента каппа-казеина человека, имеющий молекулярную массу 10,2 кДа, состоящий из остатка метионина, фрагмента каппа-казеина человека с 49 по 122 аминокислотный остаток и С-концевого гистидинового тракта, и обладающий апоптотической активностью по отношению к раковым клеткам.The invention relates to a recombinant plasmid DNA with human kappa-casein fragments, a recombinant Escherichia coli- strain producing a peptide - a human kappa-casein analog having apoptotic activity against tumor cells, and a recombinant human peptide - an analog of human kappa-casein possessing apoptotic human cells, and a recombinant human peptide - an analog of human kappa-casein, possessing apoptotic human cells, and a recombinant human peptide - an analog of human kappa-casein, possessing apoptotic human cells, and a recombinant peptide - human kappa-casein analog possessing apoptotic human cells, and a recombinant peptide - human kappa-casein analog possessing apoptotic human cells, and a recombinant peptide - human kappa-casein analog possessing apoptotic human cells, and a recombinant human peptide - human kappa-casein analog having apoptotic activity with respect to tumor cells against tumor cells, and can be used in biotechnology. The recombinant plasmid DNA pFK4 provides a higher synthesis of the recombinant peptide RL4, which is an analogue of the human kappa-casein fragment, has a molecular weight of 2.41 MDa and a size of 3653 p. The Escherichia coliXL1-Blue / pFK4 recombinant bacterial strain was deposited at the Inter-Institute Center for Collective Use of the Siberian Branch of the Russian Academy of Sciences "Collection of Extremophilic Microorganisms and Type Cultures" IHBFM SB RAS under number No. EMTC 1347 and is a producer of peptide RL4 - an analogue of the human kappa-casein fragment; to cancer cells. The obtained recombinant peptide RL4 is an analogue of the human kappa-casein fragment, having a molecular weight of 10.2 kDa, consisting of a methionine residue, a fragment of human kappa-casein with 49 to 122 amino acid residues and a C-terminal histidine tract, and having apoptotic activity against cancer cells.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201201337A EA023475B1 (en) | 2012-10-08 | 2012-10-08 | RECOMBINANT PLASMID DNA pFK4, ENSURING SYNTHESIS OF RECOMBINANT PEPTIDE RL4, WHICH IS ANALOGUE OF HUMAN KAPPA-CASEIN FRAGMENT, RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-BLUE/pFK4 AND RECOMBINANT PEPTIDE RL, ANALOGUE OF HUMAN KAPPA-CASEIN FRAGMENT, WHICH POSSESSES APOPTOTIC ACTIVITY WITH RESPECT TO CANCER CELLS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201201337A EA023475B1 (en) | 2012-10-08 | 2012-10-08 | RECOMBINANT PLASMID DNA pFK4, ENSURING SYNTHESIS OF RECOMBINANT PEPTIDE RL4, WHICH IS ANALOGUE OF HUMAN KAPPA-CASEIN FRAGMENT, RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-BLUE/pFK4 AND RECOMBINANT PEPTIDE RL, ANALOGUE OF HUMAN KAPPA-CASEIN FRAGMENT, WHICH POSSESSES APOPTOTIC ACTIVITY WITH RESPECT TO CANCER CELLS |
Publications (2)
Publication Number | Publication Date |
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EA201201337A1 true EA201201337A1 (en) | 2014-04-30 |
EA023475B1 EA023475B1 (en) | 2016-06-30 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA201201337A EA023475B1 (en) | 2012-10-08 | 2012-10-08 | RECOMBINANT PLASMID DNA pFK4, ENSURING SYNTHESIS OF RECOMBINANT PEPTIDE RL4, WHICH IS ANALOGUE OF HUMAN KAPPA-CASEIN FRAGMENT, RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-BLUE/pFK4 AND RECOMBINANT PEPTIDE RL, ANALOGUE OF HUMAN KAPPA-CASEIN FRAGMENT, WHICH POSSESSES APOPTOTIC ACTIVITY WITH RESPECT TO CANCER CELLS |
Country Status (1)
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EA (1) | EA023475B1 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK8892D0 (en) * | 1992-01-23 | 1992-01-23 | Symbicom Ab | HUMANT PROTEING |
RU2317304C1 (en) * | 2006-04-17 | 2008-02-20 | Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (СО РАН) | Peptide possessing apoptotic activity with respect to human cancer cells |
RU2401307C1 (en) * | 2009-05-15 | 2010-10-10 | Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) | RECOMBINANT PLASMID DNA pFK2 PROVIDING SYNTHESIS OF RECOMBINANT PEPTIDE BEING HUMAN KAPPA CASEIN FRAGMENT ANALOGUE, METHOD FOR PREPARING RECOMBINANT PEPTIDE, AND RECOMBINANT PEPTIDE, HUMAN KAPPA CASEIN FRAGMENT ANALOGUE EXHIBITING APOPTOTIC ACTIVITY IN RELATION TO MALIGNANT CELLS |
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2012
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EA023475B1 (en) | 2016-06-30 |
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