EA201101397A1 - Inhibitors of Human Immunodeficiency Virus Replication - Google Patents
Inhibitors of Human Immunodeficiency Virus ReplicationInfo
- Publication number
- EA201101397A1 EA201101397A1 EA201101397A EA201101397A EA201101397A1 EA 201101397 A1 EA201101397 A1 EA 201101397A1 EA 201101397 A EA201101397 A EA 201101397A EA 201101397 A EA201101397 A EA 201101397A EA 201101397 A1 EA201101397 A1 EA 201101397A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitors
- immunodeficiency virus
- human immunodeficiency
- virus replication
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
В заявке описаны соединения формулы (I)в которой R, R, A, А, А, А, Х и Y являются такими, как определено в настоящем изобретении, применимые в качестве ингибиторов репликации ВИЧ (вирус иммунодефицита человека).The application describes compounds of formula (I) in which R, R, A, A, A, A, X, and Y are as defined herein, useful as inhibitors of HIV replication (human immunodeficiency virus).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16803209P | 2009-04-09 | 2009-04-09 | |
US26368909P | 2009-11-23 | 2009-11-23 | |
PCT/CA2010/000478 WO2010115264A1 (en) | 2009-04-09 | 2010-04-07 | Inhibitors of hiv replication |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201101397A1 true EA201101397A1 (en) | 2012-05-30 |
Family
ID=42934876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201101397A EA201101397A1 (en) | 2009-04-09 | 2010-04-07 | Inhibitors of Human Immunodeficiency Virus Replication |
Country Status (15)
Country | Link |
---|---|
US (1) | US8349839B2 (en) |
EP (1) | EP2417140B1 (en) |
JP (1) | JP5643290B2 (en) |
KR (1) | KR20120034592A (en) |
CN (1) | CN102388051A (en) |
AR (1) | AR076252A1 (en) |
AU (1) | AU2010234241A1 (en) |
BR (1) | BRPI1014821A2 (en) |
CA (1) | CA2758149A1 (en) |
CL (1) | CL2011002258A1 (en) |
EA (1) | EA201101397A1 (en) |
IL (1) | IL214606A0 (en) |
MX (1) | MX2011010582A (en) |
TW (1) | TW201103940A (en) |
WO (1) | WO2010115264A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2013091096A1 (en) | 2011-12-20 | 2013-06-27 | Boehringer Ingelheim International Gmbh | Condensed triclyclic compounds as inhibitors of hiv replication |
JP6820854B2 (en) * | 2015-01-18 | 2021-01-27 | エスアールアイ インターナショナルSRI International | MAP4K4 (HGK) inhibitor |
AU2016215432B2 (en) | 2015-02-02 | 2020-07-30 | Valo Early Discovery, Inc. | 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors |
TW201636329A (en) | 2015-02-02 | 2016-10-16 | 佛瑪治療公司 | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
IL275490B1 (en) | 2017-12-22 | 2024-01-01 | Ravenna Pharmaceuticals Inc | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
WO2020028482A1 (en) * | 2018-07-31 | 2020-02-06 | The Trustees Of The University Of Pennsylvania | Small molecules that sensitize hiv-1 infected cells to antibody dependent cellular cytotoxicity |
CN111560022A (en) * | 2020-05-13 | 2020-08-21 | 深圳职业技术学院 | Tetrahydrobenzofuran [3,2-d ] pyrimidine derivative and preparation method and application thereof |
CN116332947A (en) * | 2021-12-24 | 2023-06-27 | 上海海和药物研究开发股份有限公司 | Pyrimidine-2 (1H) -keto bicyclic compounds with MAT2A inhibitory activity and application thereof |
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US8016A (en) * | 1851-04-01 | Improvement in the manufacture of india-rubber | ||
JPH06172365A (en) * | 1992-12-11 | 1994-06-21 | Yamasa Shoyu Co Ltd | 10-thiaisoalloxazine derivative and its use |
JPH06220059A (en) * | 1993-01-28 | 1994-08-09 | Tanabe Seiyaku Co Ltd | Condensed pyrimidine derivative and its production |
US6593337B1 (en) * | 1999-10-19 | 2003-07-15 | Bristol-Myers Squibb Pharma Company | Tricyclic compounds useful as HIV reverse transcriptase inhibitors |
EP1209158A1 (en) | 2000-11-18 | 2002-05-29 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines |
TWI270547B (en) * | 2000-06-16 | 2007-01-11 | Boehringer Ingelheim Ca Ltd | Non-nucleoside reverse transcriptase inhibitors |
US7008958B2 (en) | 2002-05-21 | 2006-03-07 | Bristol-Myers Squibb Company | 2-substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same |
US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
US7884221B2 (en) | 2002-11-08 | 2011-02-08 | Kaneka Corporation | Method of separating ergosterol |
JP2006508145A (en) | 2002-11-15 | 2006-03-09 | テイボテク・フアーマシユーチカルズ・リミテツド | Substituted indole pyridinium as an anti-infective compound |
US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
WO2004096807A2 (en) * | 2003-04-28 | 2004-11-11 | Tibotec Pharmaceuticals Ltd. | Hiv integrase inhibitors |
US20060074124A1 (en) | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
US7435735B2 (en) * | 2003-10-20 | 2008-10-14 | Merck & Co., Inc. | Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors |
WO2005076861A2 (en) * | 2004-02-04 | 2005-08-25 | University Of Virginia Patent Foundation | Compounds that inhibit hiv particle formation |
CN1976930B (en) | 2004-05-17 | 2011-01-19 | 泰博特克药品有限公司 | 6,7,8,9-substituted 1-phenyl-1,5-dihydro-pyrido(3,2-b)indol-2-ones useful as anti-infective pharmaceutical agents |
AP2006003791A0 (en) | 2004-05-17 | 2006-10-31 | Tibotec Pharm Ltd | 1-Heterocyclyl-1,5-dihydro-pyridoÄ3,2-BÜindol-2-ones |
AR052304A1 (en) * | 2004-05-17 | 2007-03-14 | Tibotec Pharm Ltd | COMPOUNDS 1,5- DIHIDRO - PIRIDO (3,2-B) INDOL-2-ONAS4- REPLACED, PHARMACEUTICAL COMPOSITION AND COMPOSITE PREPARATION PROCESS |
AR049102A1 (en) | 2004-05-17 | 2006-06-28 | Tibotec Pharm Ltd | PHENYL DERIVATIVES - 1, 5 - DIHIDRO - PIRIDO [3,2 -B] INDOL - 2 - WAVES 5- SUBSTITUTED AND DERIVATIVES OF PHENYL - 2 - OXO - 1,2 - DIHYDRO - BENZO [4, 5] FURO [3 , 2 -B] PIRIDIN - 3 - CARBONITRILE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND ITS USE AS A MEDICINAL PRODUCT WITH INHIBITORY ACTIVITY OF HIV VIRUS. |
WO2005110411A1 (en) * | 2004-05-17 | 2005-11-24 | Tibotec Pharmaceuticals Ltd. | Combinations of substituted 1-phenyl-1,5-dihydro-pyrido- [3,2-b] indol-2-ones and other hiv inhibitors |
ES2341559T3 (en) * | 2004-07-23 | 2010-06-22 | The Medicines Company (Leipzig) Gmbh | PIRIDO (3 ', 2': 4,5) HAVING (3,2-D) PYRIMIDINES AND PIRIDO (3 ', 2': 4,5) FURO (3,2-D) PIRIMIDINES REPLACED FOR USE AS INHIBITORS OF THE RELEASE OF PDA-4 AND / OR TNF-ALFA. |
DE602005025900D1 (en) | 2004-09-30 | 2011-02-24 | Boehringer Ingelheim Pharma | ALKYNIL-BASED DERIVATIVES OF BENZOPHENONES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS |
CA2583622A1 (en) | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
AR066386A1 (en) | 2004-12-17 | 2009-08-19 | Glenmark Pharmaceuticals Sa | CONDENSED HETEROCICLICAL COMPOUNDS, METHODS AND INTERMEDIARIES FOR THEIR PREPARATION, A PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THEIR USE IN THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF PDE-4 |
WO2006074192A2 (en) | 2005-01-03 | 2006-07-13 | Bionaut Pharmaceuticals, Inc. | Treatment of inflammatory disorders |
WO2007025090A2 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase |
JP2009525310A (en) * | 2006-02-03 | 2009-07-09 | テイボテク・フアーマシユーチカルズ・リミテツド | Methods for treating mutated HIV |
WO2008037783A1 (en) | 2006-09-29 | 2008-04-03 | Tibotec Pharmaceuticals Ltd. | Process for preparing 2-oxo-2,5-dihydro-1h-pyrido[3,2-b]indole-3-carbonitriles |
DE102006062203A1 (en) * | 2006-12-22 | 2008-06-26 | Curacyte Discovery Gmbh | Substituted 5H-pyrimido [5,4-b] indoles as inducers of apoptosis in B-CLL cells |
WO2008101867A1 (en) | 2007-02-19 | 2008-08-28 | Smithkline Beecham Corporation | Purine derivatives as immunomodulators |
WO2008119070A1 (en) | 2007-03-28 | 2008-10-02 | Trustees Of Boston University | Methods of treatment using sirt modulators and compositions containing sirt1 modulators |
WO2009085185A1 (en) | 2007-12-19 | 2009-07-09 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
-
2010
- 2010-04-07 KR KR1020117023696A patent/KR20120034592A/en not_active Application Discontinuation
- 2010-04-07 EA EA201101397A patent/EA201101397A1/en unknown
- 2010-04-07 BR BRPI1014821A patent/BRPI1014821A2/en not_active Application Discontinuation
- 2010-04-07 JP JP2012503835A patent/JP5643290B2/en active Active
- 2010-04-07 CN CN2010800156236A patent/CN102388051A/en active Pending
- 2010-04-07 AU AU2010234241A patent/AU2010234241A1/en not_active Abandoned
- 2010-04-07 CA CA2758149A patent/CA2758149A1/en not_active Abandoned
- 2010-04-07 WO PCT/CA2010/000478 patent/WO2010115264A1/en active Application Filing
- 2010-04-07 EP EP10761139.4A patent/EP2417140B1/en active Active
- 2010-04-07 MX MX2011010582A patent/MX2011010582A/en unknown
- 2010-04-08 US US12/756,276 patent/US8349839B2/en active Active
- 2010-04-08 AR ARP100101202A patent/AR076252A1/en unknown
- 2010-04-08 TW TW099110936A patent/TW201103940A/en unknown
-
2011
- 2011-08-11 IL IL214606A patent/IL214606A0/en unknown
- 2011-09-12 CL CL2011002258A patent/CL2011002258A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20120034592A (en) | 2012-04-12 |
CN102388051A (en) | 2012-03-21 |
US8349839B2 (en) | 2013-01-08 |
BRPI1014821A2 (en) | 2016-04-05 |
EP2417140A4 (en) | 2013-02-20 |
TW201103940A (en) | 2011-02-01 |
EP2417140A1 (en) | 2012-02-15 |
WO2010115264A1 (en) | 2010-10-14 |
MX2011010582A (en) | 2011-10-19 |
JP2012523380A (en) | 2012-10-04 |
EP2417140B1 (en) | 2014-11-26 |
AU2010234241A1 (en) | 2011-09-08 |
US20100261714A1 (en) | 2010-10-14 |
CA2758149A1 (en) | 2010-10-14 |
JP5643290B2 (en) | 2014-12-17 |
IL214606A0 (en) | 2011-09-27 |
AR076252A1 (en) | 2011-05-26 |
CL2011002258A1 (en) | 2012-02-10 |
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