EA201001517A1 - SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS - Google Patents

SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS

Info

Publication number
EA201001517A1
EA201001517A1 EA201001517A EA201001517A EA201001517A1 EA 201001517 A1 EA201001517 A1 EA 201001517A1 EA 201001517 A EA201001517 A EA 201001517A EA 201001517 A EA201001517 A EA 201001517A EA 201001517 A1 EA201001517 A1 EA 201001517A1
Authority
EA
Eurasian Patent Office
Prior art keywords
therapeutic compounds
substituted piperidines
compounds
piperidines
substituted
Prior art date
Application number
EA201001517A
Other languages
Russian (ru)
Inventor
Петер Херольд
Роберт Мах
Штефан Шутц
Винченцо Чинке
Александар Стояновиц
Дирк Бенке
Стьепан Елаковиц
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201001517A1 publication Critical patent/EA201001517A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Описываются соединения общей формулы (I)и их фармацевтически приемлемые соли, в которых Rимеет определения, подробно проиллюстрированные в описании, в качестве ингибиторов β-секретазы, катепсина D, плазмепсина II и/или протеазы ВИЧ.Compounds of general formula (I) and their pharmaceutically acceptable salts are described in which R has the definitions detailed in the description as inhibitors of β-secretase, cathepsin D, plasmepsin II and / or HIV protease.

EA201001517A 2008-04-02 2009-04-01 SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS EA201001517A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08153929 2008-04-02
PCT/EP2009/053898 WO2009121914A1 (en) 2008-04-02 2009-04-01 Substituted piperidines as therapeutic compounds

Publications (1)

Publication Number Publication Date
EA201001517A1 true EA201001517A1 (en) 2011-04-29

Family

ID=40627638

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001517A EA201001517A1 (en) 2008-04-02 2009-04-01 SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS

Country Status (10)

Country Link
EP (1) EP2271644A1 (en)
JP (1) JP2011516453A (en)
KR (1) KR20110002459A (en)
CN (1) CN101970431A (en)
AU (1) AU2009232012A1 (en)
BR (1) BRPI0910991A2 (en)
CA (1) CA2719070A1 (en)
EA (1) EA201001517A1 (en)
MX (1) MX2010010876A (en)
WO (1) WO2009121914A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011057160A2 (en) * 2009-11-06 2011-05-12 The Regents Of The Uiversity Of California Method to improve the immunogenicity of vaccine antigens by modification of cleavage sites in hiv-1 gp 120
UA109417C2 (en) 2009-10-14 2015-08-25 Мерк Шарп Енд Доме Корп. Substituted piperidines, which improve activity of p53, and use thereof
GB201008209D0 (en) * 2010-05-17 2010-06-30 Senexis Ltd Compounds
WO2013062923A1 (en) 2011-10-28 2013-05-02 Merck Sharp & Dohme Corp. MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF
ES2707305T3 (en) 2012-12-20 2019-04-03 Merck Sharp & Dohme Imidazopyridines substituted as HDM2 inhibitors
CN105001300A (en) * 2014-04-17 2015-10-28 复旦大学 Cathepsin D inhibitor, preparation method, pharmaceutical composition and applications thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1816122A3 (en) * 2006-01-19 2007-09-19 Speedel Experimenta AG 3,4,5-substituted piperidines as therapeutic compounds
EP1911758A1 (en) * 2006-10-04 2008-04-16 Speedel Experimenta AG Phenyl piperidine derivatives for use as renin inhibitors
EP1908761A1 (en) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organic compounds

Also Published As

Publication number Publication date
BRPI0910991A2 (en) 2016-01-19
WO2009121914A1 (en) 2009-10-08
MX2010010876A (en) 2010-10-26
JP2011516453A (en) 2011-05-26
CN101970431A (en) 2011-02-09
KR20110002459A (en) 2011-01-07
CA2719070A1 (en) 2009-10-08
EP2271644A1 (en) 2011-01-12
AU2009232012A1 (en) 2009-10-08

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