EA200870287A1 - Амидные производные в качестве лигандов ионных каналов и фармацевтические композиции и способы их применения - Google Patents

Амидные производные в качестве лигандов ионных каналов и фармацевтические композиции и способы их применения

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Publication number
EA200870287A1
EA200870287A1 EA200870287A EA200870287A EA200870287A1 EA 200870287 A1 EA200870287 A1 EA 200870287A1 EA 200870287 A EA200870287 A EA 200870287A EA 200870287 A EA200870287 A EA 200870287A EA 200870287 A1 EA200870287 A1 EA 200870287A1
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Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
ional
ligands
channels
methods
Prior art date
Application number
EA200870287A
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English (en)
Inventor
Майкл Г. Келли
Карл Дж. Коб
Джон Кинкейд
Сатьянараяна Джанагани
Госянь У
Чжи-Лян Вэй
Киран Сахасрабудхе
Мэттью Данктон
Равиндра Б. Упасани
Юньфэн Фан
Мэттью Кокс
Original Assignee
Реновис, Инк.
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Application filed by Реновис, Инк. filed Critical Реновис, Инк.
Priority claimed from PCT/US2007/004912 external-priority patent/WO2007100758A2/en
Publication of EA200870287A1 publication Critical patent/EA200870287A1/ru

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    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Описываются соединения, которые имеют формулу, представленную следующей формулой (I). Соединения можно получить в виде фармацевтических композиций, и можно применять для предотвращения или лечения различных состояний у млекопитающего, включая человека, включающих в качестве примеров боль, воспаление, травматическое повреждение и другие.
EA200870287A 2006-02-23 2007-02-22 Амидные производные в качестве лигандов ионных каналов и фармацевтические композиции и способы их применения EA200870287A1 (ru)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US77610606P 2006-02-23 2006-02-23
US77594906P 2006-02-23 2006-02-23
US77605706P 2006-02-23 2006-02-23
US77605606P 2006-02-23 2006-02-23
US77605806P 2006-02-23 2006-02-23
US77610506P 2006-02-23 2006-02-23
US77603306P 2006-02-23 2006-02-23
US77593006P 2006-02-23 2006-02-23
US77606406P 2006-02-23 2006-02-23
US77594506P 2006-02-23 2006-02-23
US83990306P 2006-08-24 2006-08-24
US83999406P 2006-08-24 2006-08-24
PCT/US2007/004912 WO2007100758A2 (en) 2005-02-28 2007-02-22 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

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CO (1) CO6170402A2 (ru)
EA (1) EA200870287A1 (ru)
GB (1) GB2452142A (ru)
IL (1) IL193346A0 (ru)
MA (1) MA30267B1 (ru)
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DE102011014994A1 (de) * 2011-03-23 2012-09-27 Otto Bock Healthcare Gmbh Prothesenfußeinsatz und Prothesenfuß
JP6866583B2 (ja) * 2016-07-05 2021-04-28 Dic株式会社 液晶化合物

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AR045979A1 (es) * 2003-04-28 2005-11-23 Astrazeneca Ab Amidas heterociclicas
AR046276A1 (es) * 2003-10-07 2005-11-30 Renovis Inc Derivados de amida como ligandos de canales ionicos y composiciones farmaceuticas y metodos que los utilizan.
EP1775283A4 (en) * 2004-07-14 2008-12-10 Japan Tobacco Inc 3-AMINOBENZAMIDE COMPOUND AND INHIBITORS OF THE ACTIVITY OF VANILLOID RECEPTOR 1 (VR1)

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CO6170402A2 (es) 2010-06-18
NO20083898L (no) 2008-10-30
KR20080098670A (ko) 2008-11-11
TNSN08328A1 (en) 2009-12-29
GB2452142A (en) 2009-02-25
GB0814753D0 (en) 2008-09-24
JP2009527575A (ja) 2009-07-30
GB2452142A8 (en) 2009-03-18
MA30267B1 (fr) 2009-03-02
CA2641781A1 (en) 2007-09-07
IL193346A0 (en) 2009-08-03

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