EA200801838A1 - NEW HETEROCYCLIC INHIBITORS NF-kB - Google Patents

NEW HETEROCYCLIC INHIBITORS NF-kB

Info

Publication number
EA200801838A1
EA200801838A1 EA200801838A EA200801838A EA200801838A1 EA 200801838 A1 EA200801838 A1 EA 200801838A1 EA 200801838 A EA200801838 A EA 200801838A EA 200801838 A EA200801838 A EA 200801838A EA 200801838 A1 EA200801838 A1 EA 200801838A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nrr
aryl
new heterocyclic
hydroxyalkylamino
haloalkyloxy
Prior art date
Application number
EA200801838A
Other languages
Russian (ru)
Inventor
Йоганн Лебан
Харальд Шмитт
Кристина Вольф
Стефано Пегораро
Андреас Вуцик
Рольф Краусс
Original Assignee
4ЭсЦэ АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/375,259 external-priority patent/US7601745B2/en
Priority claimed from PCT/EP2006/002396 external-priority patent/WO2007016979A2/en
Application filed by 4ЭсЦэ АГ filed Critical 4ЭсЦэ АГ
Priority claimed from PCT/EP2007/002265 external-priority patent/WO2007104557A2/en
Publication of EA200801838A1 publication Critical patent/EA200801838A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Настоящее изобретение относится к соединениям общей формулы (Ih), или их фармацевтически приемлемым солям с кислотой или основанием, или к их фармацевтически приемлемым пролекарствам или стереоизомеру, где А представляет собой NR, S или О; Rпредставляет собой Н, ОН, SH, NH, -C(NR)NRR, -(СН)арил, -(CH)NRR, -C(O)NRR, -N=CRR, -NRC(O)R, алкил, циклоалкил, гидроксиалкил, галогеноалкил, галогеноалкилокси, алкокси, алкиламино, гидроксиалкиламино, галоген, арил или гетероарил; Rпредставляет собой Н, -С(O)NRR, галоген, алкил, галогеноалкил, арил, гетероарил, ОН, SH, NROR, NH, гидроксиалкиламино, алкиламино, алкокси, циклоалкил, гетероциклоалкил, гидроксиалкил или галогеноалкилокси; Х представляет собой NR, О или S; Z представляет собой N или CR.(Ih)The present invention relates to compounds of the general formula (Ih), or their pharmaceutically acceptable salts with an acid or base, or their pharmaceutically acceptable prodrugs or stereoisomer, where A is NR, S or O; R1 is H, OH, SH, NH, -C (NR) NRR, - (CH) aryl, - (CH) NRR, -C (O) NRR, -N = CRR, -NRC (O) R, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, alkoxy, alkylamino, hydroxyalkylamino, halogen, aryl or heteroaryl; R4 is H, -C (O) NRR, halogen, alkyl, haloalkyl, aryl, heteroaryl, OH, SH, NROR, NH, hydroxyalkylamino, alkylamino, alkoxy, cycloalkyl, heterocycloalkyl, hydroxyalkyl or haloalkyloxy; X is NR, O or S; Z is N or CR. (Ih)

EA200801838A 2006-03-15 2007-03-14 NEW HETEROCYCLIC INHIBITORS NF-kB EA200801838A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/375,259 US7601745B2 (en) 2004-09-27 2006-03-15 Heterocyclic NF-kB inhibitors
PCT/EP2006/002396 WO2007016979A2 (en) 2005-07-29 2006-03-15 NOVEL HETEROCYCLIC NF-κB INHIBITORS
PCT/EP2007/002265 WO2007104557A2 (en) 2006-03-15 2007-03-14 Novel heterocyclic nf-kb inhibitors

Publications (1)

Publication Number Publication Date
EA200801838A1 true EA200801838A1 (en) 2009-02-27

Family

ID=39869768

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801838A EA200801838A1 (en) 2006-03-15 2007-03-14 NEW HETEROCYCLIC INHIBITORS NF-kB

Country Status (8)

Country Link
JP (1) JP2009529555A (en)
KR (1) KR20080104147A (en)
AU (1) AU2007224659A1 (en)
BR (1) BRPI0709595A2 (en)
CA (1) CA2646223A1 (en)
EA (1) EA200801838A1 (en)
IL (1) IL193981A0 (en)
MX (1) MX2008011696A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010011917A (en) * 2008-05-05 2010-11-26 Merck Patent Gmbh Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders.
WO2010059602A2 (en) * 2008-11-19 2010-05-27 Schering Corporation Inhibitors of diacylglycerol acyltransferase
EP2748172B1 (en) * 2011-09-30 2017-12-06 Kineta, Inc. Anti-viral compounds
US10005769B2 (en) * 2013-06-18 2018-06-26 4Sc Ag 2,3-dihydrobenzofuran-5YL compounds as DYRK kinase inhibitors
SI3099684T1 (en) * 2014-01-29 2018-08-31 Ucb Biopharma Sprl Heteroaryl amides as inhibitors of protein aggregation
KR101693035B1 (en) 2015-01-14 2017-01-06 충북대학교 산학협력단 1,2,3,4-Tetrahydroquinoline-2-carboxylic acid N- (Substituted)phenylamide Derivatives and Uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004067510A (en) * 1997-12-26 2004-03-04 Mitsubishi Pharma Corp New imidazole derivative
WO2002064558A2 (en) * 2001-02-14 2002-08-22 Sankyo Company, Limited Oxazole derivatives, their preparation and their use as cytokine inhibitors
GB0230162D0 (en) * 2002-12-24 2003-02-05 Metris Therapeutics Ltd Compounds useful in inhibiting angiogenesis
FR2856685B1 (en) * 2003-06-25 2005-09-23 Merck Sante Sas THIAZOLYLPIPERIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
EA012607B1 (en) * 2004-09-20 2009-10-30 4Сц Аг NOVEL HETEROCYCLIC NF-kB INHIBITORS
NZ588971A (en) * 2005-07-29 2012-06-29 4Sc Discovery Gmbh Novel heterocyclic NF-kappaB inhibitors

Also Published As

Publication number Publication date
IL193981A0 (en) 2009-08-03
KR20080104147A (en) 2008-12-01
JP2009529555A (en) 2009-08-20
CA2646223A1 (en) 2007-09-20
MX2008011696A (en) 2008-11-12
AU2007224659A1 (en) 2007-09-20
BRPI0709595A2 (en) 2011-07-19

Similar Documents

Publication Publication Date Title
EA200800175A1 (en) NEW HETEROCYCLIC INHIBITORS NF-κB
EA200801838A1 (en) NEW HETEROCYCLIC INHIBITORS NF-kB
WO2007104557A3 (en) Novel heterocyclic nf-kb inhibitors
EA200970172A1 (en) PRINCIPLE OF CONNECTION AMIDA BOROIC ACID
ES2570756T3 (en) Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and use as kinase inhibitors
CY1112914T1 (en) Substituted Indolyl Alkyl Amine Derivatives as New Suspensions of Hastonine Disinfectants
RU2015121431A (en) SUBSTITUTED INDOL-5-OLA DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
EA200900934A1 (en) NEW HETEROCYCLIC INHIBITORS NF-κB
ECSP12012212A (en) ARYLETINYL DERIVATIVES
CO6260023A2 (en) PHOSPHORAMIDATE NEUCLEID PRODUCTS
EA201170096A1 (en) SUBSTITUTED PYRIMIDON DERIVATIVES
EA200700441A1 (en) NEW HETEROCYCLIC INHIBITORS NF-κB
EA201791781A1 (en) DERIVATIVES OF THE SUBSTITUTED MONO- AND POLYAZANAPTALINE AND THEIR APPLICATION
ES2531002T3 (en) Kinase Inhibitor Compounds
CO6160296A2 (en) BENZOAZEPIN-OXI-ACETIC ACID DERIVATIVES AS RECEPTOR AGONISTS ACTIVATED BY DELTA PEROXISONE PROLIFERATOR USED TO INCREASE HIGH-DENSITY LIPOPROTEIN-CHOLESTEROL-CHOLESTEROL REDUCE LIPOPROTEIN-LOW DENSITY-COLESTEROL
CO6321274A2 (en) PIRAZOL ACETAMIDE N-SUBSTITUTED COMPOUNDS AS GLUCOQUINASE ACTIVATORS
RS52872B (en) Pyrrole compounds
AR077598A1 (en) FUSIONED HETEROCICLIC COMPOUNDS AS MODULAR ION CHANNELS
CO6220967A2 (en) ORGANIC COMPOUNDS AND THEIR USES
EA201000881A1 (en) Pyridylmethyl-sulfonamide compounds
CY1117862T1 (en) Heterocyclic benzodioxolium or benzodioxepine compounds as phosphodiesterase inhibitors
UY29023A1 (en) PROCEDURE FOR PREPARATION OF DERIVATIVES N- PIPERIDINO - 1, 5 - DIFENILPIRAZOL - 3 - CARBOXAMIDA.-
CR10671A (en) AZABICICLIC COMPOUNDS AS INHIBITORS OF MONOAMINE RECAPTATION
MA32956B1 (en) 5-AMINO-2- (1-HYDROXYETHYL) -TETRAHYDROPYRANE DERIVATIVES
EA201171000A1 (en) Derivative azaspranililkilkarbamatov in the form of 5-member heterocycles, the method of their production and use in therapy