EA200701894A1 - Уровень транскрипции гена timp3 в качестве диагностического маркера немелкоклеточного рака легких - Google Patents
Уровень транскрипции гена timp3 в качестве диагностического маркера немелкоклеточного рака легкихInfo
- Publication number
- EA200701894A1 EA200701894A1 EA200701894A EA200701894A EA200701894A1 EA 200701894 A1 EA200701894 A1 EA 200701894A1 EA 200701894 A EA200701894 A EA 200701894A EA 200701894 A EA200701894 A EA 200701894A EA 200701894 A1 EA200701894 A1 EA 200701894A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- lung cancer
- cell lung
- level
- transcription
- small
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Настоящее изобретение относится к области медицины, в частности онкологии, и молекулярной биологии. Предложено в качестве маркера для диагностики немелкоклеточного рака легких использовать уровень транскрипции гена TIMP3. Сниженный уровень транскрипции в предположительно пораженной раком ткани человека по сравнению с ее уровнем в здоровой ткани служит диагностическим признаком немелкоклеточного рака легких. Предложенное изобретение позволяет с высокой достоверностью диагностировать немелкоклеточный рак легких, включая плоскоклеточный рак, в том числе на самой ранней стадии прогрессии опухолевой трансформации.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/RU2006/000430 WO2008024009A1 (fr) | 2006-08-15 | 2006-08-15 | Niveau de transcription du gène timp3 utilisé en tant que marqueur servant à diagnostiquer le cancer du poumon non à petites cellules |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200701894A1 true EA200701894A1 (ru) | 2008-02-28 |
EA010571B1 EA010571B1 (ru) | 2008-10-30 |
Family
ID=39107023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200701894A EA010571B1 (ru) | 2006-08-15 | 2006-08-15 | Способ диагностики немелкоклеточного рака легких и набор для его осуществления |
Country Status (2)
Country | Link |
---|---|
EA (1) | EA010571B1 (ru) |
WO (1) | WO2008024009A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
PT3256605T (pt) | 2015-02-10 | 2022-03-17 | Univ Hong Kong Chinese | Deteção de mutações para rastreio de cancro e análise fetal |
IL305462A (en) | 2015-07-23 | 2023-10-01 | Univ Hong Kong Chinese | DNA fragmentation pattern analysis suitable clean |
TWI803477B (zh) | 2017-01-25 | 2023-06-01 | 香港中文大學 | 使用核酸片段之診斷應用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004509612A (ja) * | 2000-06-05 | 2004-04-02 | アバロン ファーマシューティカルズ | ガン遺伝子決定および特徴的な遺伝子群を用いた治療用スクリーニング |
DE10161625A1 (de) * | 2001-12-14 | 2003-07-10 | Epigenomics Ag | Verfahren und Nukleinsäuren für die Analyse einer Lungenzell-Zellteilungsstörung |
-
2006
- 2006-08-15 WO PCT/RU2006/000430 patent/WO2008024009A1/ru active Application Filing
- 2006-08-15 EA EA200701894A patent/EA010571B1/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2008024009A1 (fr) | 2008-02-28 |
EA010571B1 (ru) | 2008-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |