EA200601368A1 - Макролиды, обладающие противовоспалительной активностью - Google Patents

Макролиды, обладающие противовоспалительной активностью

Info

Publication number
EA200601368A1
EA200601368A1 EA200601368A EA200601368A EA200601368A1 EA 200601368 A1 EA200601368 A1 EA 200601368A1 EA 200601368 A EA200601368 A EA 200601368A EA 200601368 A EA200601368 A EA 200601368A EA 200601368 A1 EA200601368 A1 EA 200601368A1
Authority
EA
Eurasian Patent Office
Prior art keywords
macrolides
inflammatory activity
prevention
contain
formula
Prior art date
Application number
EA200601368A
Other languages
English (en)
Other versions
EA010906B1 (ru
Inventor
Андреа Мереу
Мауро Наполетано
Фернандо Орнаги
Фернандо Моригги
Франко Пеллачини
Original Assignee
Дзамбон Гроуп С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзамбон Гроуп С.П.А. filed Critical Дзамбон Гроуп С.П.А.
Publication of EA200601368A1 publication Critical patent/EA200601368A1/ru
Publication of EA010906B1 publication Critical patent/EA010906B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Описаны макролидные соединения формулы I, в которой X, R, R, R, Rи Rимеют значения, определенные в описании, их фармацевтические приемлемые соли, фармацевтические составы, которые содержат их в качестве активных ингредиентов, а также их применение для лечения и профилактики воспалительных заболеваний.
EA200601368A 2004-01-29 2005-01-25 Макролиды, обладающие противовоспалительной активностью EA010906B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000124A ITMI20040124A1 (it) 2004-01-29 2004-01-29 Macrolidi ad attivita' antiinfiammatoria
PCT/EP2005/050312 WO2005075494A1 (en) 2004-01-29 2005-01-25 Macrolides with antiinflammatory activity

Publications (2)

Publication Number Publication Date
EA200601368A1 true EA200601368A1 (ru) 2007-02-27
EA010906B1 EA010906B1 (ru) 2008-12-30

Family

ID=34835570

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601368A EA010906B1 (ru) 2004-01-29 2005-01-25 Макролиды, обладающие противовоспалительной активностью

Country Status (10)

Country Link
US (1) US7507721B2 (ru)
EP (1) EP1713818A1 (ru)
JP (1) JP4709774B2 (ru)
CN (1) CN1956993B (ru)
AU (1) AU2005210032B9 (ru)
CA (1) CA2554070C (ru)
EA (1) EA010906B1 (ru)
IL (1) IL176846A (ru)
IT (1) ITMI20040124A1 (ru)
WO (1) WO2005075494A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US20080249034A1 (en) * 2005-03-21 2008-10-09 Zambon S.P.A. Use of Macrolides for Treating Intestinal Inflammation
RU2455308C2 (ru) 2006-05-01 2012-07-10 Тайсо Фармасьютикал Ко., Лтд. Макролидные производные
CN101558078B (zh) * 2006-12-12 2013-08-21 萨宝公司 具有抗炎活性的大环内酯化合物
US20230129438A1 (en) * 2020-03-12 2023-04-27 Zoetis Services Llc Immunomodulating imine-oxazoline azalides
WO2023038852A1 (en) * 2021-09-07 2023-03-16 Zoetis Services Llc Immunomodulating azalides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215980A (en) 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
IT1306205B1 (it) * 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
ITMI20021726A1 (it) * 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.

Also Published As

Publication number Publication date
IL176846A0 (en) 2006-10-31
AU2005210032B9 (en) 2011-06-09
CA2554070C (en) 2011-10-11
US20070167381A1 (en) 2007-07-19
WO2005075494A1 (en) 2005-08-18
CN1956993A (zh) 2007-05-02
CA2554070A1 (en) 2005-08-18
AU2005210032A1 (en) 2005-08-18
CN1956993B (zh) 2012-10-31
AU2005210032B2 (en) 2011-01-20
EP1713818A1 (en) 2006-10-25
JP4709774B2 (ja) 2011-06-22
EA010906B1 (ru) 2008-12-30
US7507721B2 (en) 2009-03-24
IL176846A (en) 2011-01-31
ITMI20040124A1 (it) 2004-04-29
JP2007519685A (ja) 2007-07-19

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU